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Transfer of Topically Applied Tetracycline in Various Vehicles

Transfer of Topically Applied Tetracycline in Various Vehicles Abstract • Fifty hospitalized dermatology patients participated in a study to evaluate the transfer of topically applied tetracycline hydrochloride-containing fluorescent ointments, creams, lotions, and tinctures from various sites of application. Patients were examined with a Wood's lamp 24 hours after application to determine the sites and areas of transfer. The topically applied medications did not remain confined to sites of initial application. The anatomic sites of initial application determined the pattern of transfer. Certain patterns of transfer were characteristic among groups of patients and for specific patients. The vehicle of the topical preparation greatly influenced the extent and sites of transfer. (Arch Dermatol 1983;119:660-663) References 1. Fox H: On the therapeutic testing of dermatological remedies . J Cutan Dis 1909;27:192-199. 2. Sulzberger MB: Evaluation of therapeutic agents on the human skin: Method of simultaneous symmetrical paired comparisons . Clin Pharmacol Ther 1962;3:1-4. 3. Marples RR, Kligman AM: Limitations of paired comparisons of topical drugs . Br J Dermatol 1973;88:61-67.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Transfer of Topically Applied Tetracycline in Various Vehicles

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Publisher
American Medical Association
Copyright
Copyright © 1983 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1983.01650320034012
Publisher site
See Article on Publisher Site

Abstract

Abstract • Fifty hospitalized dermatology patients participated in a study to evaluate the transfer of topically applied tetracycline hydrochloride-containing fluorescent ointments, creams, lotions, and tinctures from various sites of application. Patients were examined with a Wood's lamp 24 hours after application to determine the sites and areas of transfer. The topically applied medications did not remain confined to sites of initial application. The anatomic sites of initial application determined the pattern of transfer. Certain patterns of transfer were characteristic among groups of patients and for specific patients. The vehicle of the topical preparation greatly influenced the extent and sites of transfer. (Arch Dermatol 1983;119:660-663) References 1. Fox H: On the therapeutic testing of dermatological remedies . J Cutan Dis 1909;27:192-199. 2. Sulzberger MB: Evaluation of therapeutic agents on the human skin: Method of simultaneous symmetrical paired comparisons . Clin Pharmacol Ther 1962;3:1-4. 3. Marples RR, Kligman AM: Limitations of paired comparisons of topical drugs . Br J Dermatol 1973;88:61-67.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Aug 1, 1983

References