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Transcatheter Aortic Valve Replacement in Low-risk Patients With Bicuspid Aortic Valve Stenosis

Transcatheter Aortic Valve Replacement in Low-risk Patients With Bicuspid Aortic Valve Stenosis Key PointsQuestionWhat are the procedural and short-term outcomes of transcatheter aortic valve replacement (TAVR) in low-risk patients with bicuspid aortic valve stenosis? FindingsIn this single-arm prospective study of 150 low-risk patients with bicuspid aortic valve stenosis undergoing TAVR using a self-expanding valve and a standardized sizing strategy, there was high device success with a low rate of death or disabling stroke at 30 days. Outcomes did not vary significantly by bicuspid type (Sievers classification), with excellent hemodynamics and low rates of significant paravalvular leak for both Sievers type 0 and type I bicuspid valves. MeaningIn this study, low-risk patients with bicuspid aortic valve stenosis undergoing TAVR had excellent procedural and 30-day outcomes, but longer-term outcomes are needed prior to widespread adoption of TAVR in low-risk patients with bicuspid severe aortic stenosis. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Cardiology American Medical Association

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Publisher
American Medical Association
Copyright
Copyright 2020 American Medical Association. All Rights Reserved.
ISSN
2380-6583
eISSN
2380-6591
DOI
10.1001/jamacardio.2020.4738
Publisher site
See Article on Publisher Site

Abstract

Key PointsQuestionWhat are the procedural and short-term outcomes of transcatheter aortic valve replacement (TAVR) in low-risk patients with bicuspid aortic valve stenosis? FindingsIn this single-arm prospective study of 150 low-risk patients with bicuspid aortic valve stenosis undergoing TAVR using a self-expanding valve and a standardized sizing strategy, there was high device success with a low rate of death or disabling stroke at 30 days. Outcomes did not vary significantly by bicuspid type (Sievers classification), with excellent hemodynamics and low rates of significant paravalvular leak for both Sievers type 0 and type I bicuspid valves. MeaningIn this study, low-risk patients with bicuspid aortic valve stenosis undergoing TAVR had excellent procedural and 30-day outcomes, but longer-term outcomes are needed prior to widespread adoption of TAVR in low-risk patients with bicuspid severe aortic stenosis.

Journal

JAMA CardiologyAmerican Medical Association

Published: Jan 7, 2021

References