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TOXIN PRODUCTION BY SPIROCHAETA PALLIDA

TOXIN PRODUCTION BY SPIROCHAETA PALLIDA Abstract Nothing is definitely known of the agencies by which Spirochaeta pallida produces the lesions of syphilis. Some of the symptoms of the disease suggest the production and activity of toxins by the organism, but these have not been demonstrated. In my experiments, Mandler and Berkefeld filtrates of ascites-agar-kidney and ascites-bouillon-kidney cultures of Noguchi strains of Spirochaeta pallida grown for from three to eight weeks were found relatively nontoxic for rabbits by intratesticular injection and for young guinea-pigs by intraperitoneal inoculation. Slight local inflammatory reactions and loss in weight were no more marked than those observed with control filtrates of sterile mediums incubated for the same period and injected in similar amounts per kilogram of weight. These experiments indicated that cultures of spirochetes alleged or believed to be Spirochaeta pallida do not produce demonstrable amounts of soluble or exogenous toxins in vitro, although the results are of limited value since it References 1. Koimer, J. A., and Kast, C.: Am. J. Syph. 13:419 ( (July) ) 1929. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology and Syphilology American Medical Association

TOXIN PRODUCTION BY SPIROCHAETA PALLIDA

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Publisher
American Medical Association
Copyright
Copyright © 1929 American Medical Association. All Rights Reserved.
ISSN
0096-6029
DOI
10.1001/archderm.1929.01440020041008
Publisher site
See Article on Publisher Site

Abstract

Abstract Nothing is definitely known of the agencies by which Spirochaeta pallida produces the lesions of syphilis. Some of the symptoms of the disease suggest the production and activity of toxins by the organism, but these have not been demonstrated. In my experiments, Mandler and Berkefeld filtrates of ascites-agar-kidney and ascites-bouillon-kidney cultures of Noguchi strains of Spirochaeta pallida grown for from three to eight weeks were found relatively nontoxic for rabbits by intratesticular injection and for young guinea-pigs by intraperitoneal inoculation. Slight local inflammatory reactions and loss in weight were no more marked than those observed with control filtrates of sterile mediums incubated for the same period and injected in similar amounts per kilogram of weight. These experiments indicated that cultures of spirochetes alleged or believed to be Spirochaeta pallida do not produce demonstrable amounts of soluble or exogenous toxins in vitro, although the results are of limited value since it References 1. Koimer, J. A., and Kast, C.: Am. J. Syph. 13:419 ( (July) ) 1929.

Journal

Archives of Dermatology and SyphilologyAmerican Medical Association

Published: Aug 1, 1929

References

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