Abstract A SERIES of trustworthy investigations indicates that distribution of trachoma virus is confined to the epithelial layer of the conjunctiva.* Nevertheless, the significant clinical change in trachoma is subepithelial inflammation, e. g., follicle formation and cellular infiltration. In addition, in the acute stage of infection there is often the association of a preauricular adenopathy. Might these changes not be incurred by a toxin or toxin-like substance produced by the trachoma virus? On the other hand, a toxin or a similar factor has been demonstrated in related viruses, namely, the viruses of psittacosis and lymphogranuloma venereum. The problem as to whether trachoma virus produces a toxin or like substance may, therefore, be worthy of investigation. DESIGN OF THE EXPERIMENT Conjunctival matter from trachoma cases with a great number of inclusion bodies no doubt contains trachoma virus in high concentration. If a soluble toxin or toxin-like substance is being produced by the References 1. References 1 to 3. 2. Supplied by Dr. S. Arakawa. Institute for Infectious Diseases, Tokyo, Japan. 3. Michail, D., and Vancea, P.: Quelques faits expérimentaux dans le trachoma , Rev. internat. trachoma 9:33-36, 1932. 4. Thygeson, P., and Richards, P.: Nature of the Filtrable Agent of Trachoma , Arch. Ophth. 20:569-582, 1938.Crossref 5. Okamura, K., and Mitsui, Y.: Contagious Trachoma Virus in Subconjunctival Tissues , Acta Soc. ophth. Jap. 43:2070-2074, 1939. 6. Meyer, K. F.: Psittacosis-Lymphogranuloma Group , in Rivers, T., and others: Viral and Rickettsial Infection of Man , J. B. Lippincott Company, Philadelphia, 1948, pp. 337-357. 7. Mitsui, Y.: Use of the New Antibiotics in the Treatment of Trachoma , J. Roy. Egyptian M. A. 35:69-77, 1952.
A.M.A. Archives of Ophthalmology – American Medical Association
Published: Jul 1, 1954
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