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TOXIC EFFECTS OF PERCUTANEOUSLY ABSORBED ESTROGENS

TOXIC EFFECTS OF PERCUTANEOUSLY ABSORBED ESTROGENS The fact that steroid hormones, particularly estrogens, can pass through the skin is well known, but the potential dangers of this route of absorption have not been noted previously. For this reason, we believe that the case reported here is of considerable theoretical as well as practical interest. REPORT OF A CASE The patient, a 44 year old Scotsman, presented himself with the complaint of impotence of four months' duration. He had been married for twenty-three years and had fathered four children. His sexual activity had always been regular and satisfactory. Eighteen months before seeking medical advice he had started working as a chemist for a small pharmaceutic concern; his assignment was to extract and purify estrogenic substances from pregnancy urine. During this process his hands came in frequent contact with alcoholic solutions of high estrogenic potency, and he also admitted that occasionally he scraped freshly crystallized estrogenic materials from http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

TOXIC EFFECTS OF PERCUTANEOUSLY ABSORBED ESTROGENS

GOLDZIEHER, MAX A.; GOLDZIEHER, JOSEPH W.
JAMA , Volume 140 (14) – Aug 6, 1949
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TOXIC EFFECTS OF PERCUTANEOUSLY ABSORBED ESTROGENS

Abstract


The fact that steroid hormones, particularly estrogens, can pass through the skin is well known, but the potential dangers of this route of absorption have not been noted previously. For this reason, we believe that the case reported here is of considerable theoretical as well as practical interest.

REPORT OF A CASE
The patient, a 44 year old Scotsman, presented himself with the complaint of impotence of four months' duration. He had been married for twenty-three years and had fathered...
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References (3)

Publisher
American Medical Association
Copyright
Copyright © 1949 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1949.82900490003007a
Publisher site
See Article on Publisher Site

Abstract

The fact that steroid hormones, particularly estrogens, can pass through the skin is well known, but the potential dangers of this route of absorption have not been noted previously. For this reason, we believe that the case reported here is of considerable theoretical as well as practical interest. REPORT OF A CASE The patient, a 44 year old Scotsman, presented himself with the complaint of impotence of four months' duration. He had been married for twenty-three years and had fathered four children. His sexual activity had always been regular and satisfactory. Eighteen months before seeking medical advice he had started working as a chemist for a small pharmaceutic concern; his assignment was to extract and purify estrogenic substances from pregnancy urine. During this process his hands came in frequent contact with alcoholic solutions of high estrogenic potency, and he also admitted that occasionally he scraped freshly crystallized estrogenic materials from

Journal

JAMA – American Medical Association

Published: Aug 6, 1949

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