Abstract Topical application of a commercially available aqueous suspension of dexamethasone alcohol, 0.1%, produced measurable quantities of the steroid in both the cornea and in the aqueous humor under all three experimental ocular conditions studied. Drug bioavailability was greatest after removal of the corneal epithelium, but the alcohol derivative of dexamethasone also penetrates through the intact corneal epithelium. Comparison of our present findings with previous experimental data from this laboratory confirms the superiority of an aqueous vehicle over petrolatum ointment for delivering dexamethasone to the eye. References 1. Cox WV, Kupferman A, Leibowitz HM: Topically applied steroids in corneal disease: I. The role of inflammation in stromal absorption of dexamethasone . Arch Ophthalmol 88:308-313, 1972.Crossref 2. Cox WV, Kupferman A, Leibowitz HM: Topically applied steroids in corneal disease: II. The role of drug vehicle in stromal absorption of dexamethasone . Arch Ophthalmol 88:549-552, 1972.Crossref 3. Kupferman A, et al: Topically applied steroids in corneal disease: III. The role of drug derivative in stromal absorption of dexamethasone . Arch Ophthalmol 91:373-376, 1974.Crossref 4. Kupferman A, Leibowitz HM: Topically applied steroids in corneal disease: IV. The role of drug concentration in stromal absorption of prednisolone acetate . Arch Ophthalmol 91:377-380, 1974.Crossref 5. Hodgman CD (ed): Handbook of Chemistry and Physics , ed 48. Cleveland, Chemical Rubber Publishing Co, of Cleveland, 1967. 6. Flynn GL, Lamb DJ: Factors influencing solvolysis of corticosteroid-21-phosphate esters . J Pharm Sci 59:1433-1438, 1970.Crossref
Archives of Ophthalmology – American Medical Association
Published: Oct 1, 1974
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