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Topically Administered Fluorouracil in Psoriasis

Topically Administered Fluorouracil in Psoriasis Abstract In 13 patients with psoriasis, fluorouracil at 5% concentration in ointment base was applied daily to psoriatic lesions under the occlusive dressings. The treated lesions became completely erosive at seven to nine trials, preceded by a burning sensation and accompanied by pain. A rapid epithelization was seen soon after stopping the fluorouracil treatment. Thus, all the patients showed a complete clearing of the lesions treated with the antimetabolite, and the psoriasis has not recurred during the observation period ranging from 6 to 13 months, except in a patient in whom small psoriatic lesions recurred after 11 months. The characteristic features of histological response of psoriatic lesions to fluorouracil was the destructive degeneration of the epidermal cells, mainly edema and vacuolated degeneration, leading to necrobiosis. No systemic toxicity was found in this series of patients. References 1. Gubner R: Effect of aminopterin on epithelial tissues . Arch Derm 64:688-699, 1951.Crossref 2. Van Scott EJ, Reinertson RP: Morphologic and physiologic effects of chemotherapeutic agents in psoriasis . J Invest Derm 33:357-369, 1959.Crossref 3. Kravetz RE, Balsam T: Treatment of psoriasis with mercaptopurine . Arch Derm 84:597-600. 1961.Crossref 4. Turner RW, Calabres P: The effect of triacetyl azauridine of psoriasis . J Invest Derm 43: 551-557, 1964.Crossref 5. Calabresi P, Welch AD: Cytotoxic drugs, hormones, and radioactive isotopes , in Goodman LS, Gilman A (eds): The Pharmacological Basis of Therapeutics . London, Collier-Macmillan Ltd, 1969, pp 1345-1392. 6. Muller SA, Farrow GM, Martalock DL: Cirrhosis caused by methotrexate in the treatment of psoriasis . Arch Derm 100:523-530, 1969.Crossref 7. Condit PT, Chanes RE, Joel W: Renal toxicity of methotrexate . Cancer 23:126-131, 1969.Crossref 8. Dillaha CJ, Jansen GT, Honeycutt WM, et al: Further studies with topical 5-fluorouracil . Arch Derm 92:410-417, 1965.Crossref 9. Klein E, Milgrom H, Helm F, et al: Tumors of the skin: I. Effects of local use of cytostatic agents . Skin 1:81-87, 1962. 10. Dillaha CJ, Jansen GT, Honeycutt WM, et al: Selective cytotoxic effect of topical 5-fluorouracil . Arch Derm 88:247-256, 1963.Crossref 11. Klein E, Stoll HL, Miller E, et al: The effect of 5-fluorouracil (5-FU) ointment in the treatment of neoplastic dermatoses . Dermatologica 140( (suppl 1) ):21-33, 1970.Crossref 12. Reymann F: Treatment of basal cell carcinoma with 5-fluorouracil (5-FU) ointment . Dermatologica 140( (suppl 1) ):34-41, 1970.Crossref 13. Ebner H: Treatment of skin epitheliomas with 5-fluorouracil (5-FU) ointment: Influence of therapeutic design on recurrence of lesions . Dermatologica 140( (suppl 1) ):42-46, 1970.Crossref 14. Nurse DS: Effect of antimetabolites on epidermal structures . Arch Derm 87:258-265, 1963.Crossref 15. Fry L, McMinn RMH: Topical methotrexate in psoriasis . Arch Derm 96:483-488, 1967.Crossref 16. Van Scott EJ: Reaction patterns of normal and neoplastic epithelium , in Montagna W, Dobson RL (eds): Carcinogenesis: Advances in Biology of Skin . New York, Pergamon Pess Inc, 1966, vol 7, pp 75-87. 17. Mandy S, Taylor JR, Halprin K: Topically applied mechlorethamine in the treatment of psoriasis . Arch Derm 103:272-276, 1971.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Topically Administered Fluorouracil in Psoriasis

Archives of Dermatology , Volume 105 (2) – Feb 1, 1972

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Publisher
American Medical Association
Copyright
Copyright © 1972 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1972.01620050022003
Publisher site
See Article on Publisher Site

Abstract

Abstract In 13 patients with psoriasis, fluorouracil at 5% concentration in ointment base was applied daily to psoriatic lesions under the occlusive dressings. The treated lesions became completely erosive at seven to nine trials, preceded by a burning sensation and accompanied by pain. A rapid epithelization was seen soon after stopping the fluorouracil treatment. Thus, all the patients showed a complete clearing of the lesions treated with the antimetabolite, and the psoriasis has not recurred during the observation period ranging from 6 to 13 months, except in a patient in whom small psoriatic lesions recurred after 11 months. The characteristic features of histological response of psoriatic lesions to fluorouracil was the destructive degeneration of the epidermal cells, mainly edema and vacuolated degeneration, leading to necrobiosis. No systemic toxicity was found in this series of patients. References 1. Gubner R: Effect of aminopterin on epithelial tissues . Arch Derm 64:688-699, 1951.Crossref 2. Van Scott EJ, Reinertson RP: Morphologic and physiologic effects of chemotherapeutic agents in psoriasis . J Invest Derm 33:357-369, 1959.Crossref 3. Kravetz RE, Balsam T: Treatment of psoriasis with mercaptopurine . Arch Derm 84:597-600. 1961.Crossref 4. Turner RW, Calabres P: The effect of triacetyl azauridine of psoriasis . J Invest Derm 43: 551-557, 1964.Crossref 5. Calabresi P, Welch AD: Cytotoxic drugs, hormones, and radioactive isotopes , in Goodman LS, Gilman A (eds): The Pharmacological Basis of Therapeutics . London, Collier-Macmillan Ltd, 1969, pp 1345-1392. 6. Muller SA, Farrow GM, Martalock DL: Cirrhosis caused by methotrexate in the treatment of psoriasis . Arch Derm 100:523-530, 1969.Crossref 7. Condit PT, Chanes RE, Joel W: Renal toxicity of methotrexate . Cancer 23:126-131, 1969.Crossref 8. Dillaha CJ, Jansen GT, Honeycutt WM, et al: Further studies with topical 5-fluorouracil . Arch Derm 92:410-417, 1965.Crossref 9. Klein E, Milgrom H, Helm F, et al: Tumors of the skin: I. Effects of local use of cytostatic agents . Skin 1:81-87, 1962. 10. Dillaha CJ, Jansen GT, Honeycutt WM, et al: Selective cytotoxic effect of topical 5-fluorouracil . Arch Derm 88:247-256, 1963.Crossref 11. Klein E, Stoll HL, Miller E, et al: The effect of 5-fluorouracil (5-FU) ointment in the treatment of neoplastic dermatoses . Dermatologica 140( (suppl 1) ):21-33, 1970.Crossref 12. Reymann F: Treatment of basal cell carcinoma with 5-fluorouracil (5-FU) ointment . Dermatologica 140( (suppl 1) ):34-41, 1970.Crossref 13. Ebner H: Treatment of skin epitheliomas with 5-fluorouracil (5-FU) ointment: Influence of therapeutic design on recurrence of lesions . Dermatologica 140( (suppl 1) ):42-46, 1970.Crossref 14. Nurse DS: Effect of antimetabolites on epidermal structures . Arch Derm 87:258-265, 1963.Crossref 15. Fry L, McMinn RMH: Topical methotrexate in psoriasis . Arch Derm 96:483-488, 1967.Crossref 16. Van Scott EJ: Reaction patterns of normal and neoplastic epithelium , in Montagna W, Dobson RL (eds): Carcinogenesis: Advances in Biology of Skin . New York, Pergamon Pess Inc, 1966, vol 7, pp 75-87. 17. Mandy S, Taylor JR, Halprin K: Topically applied mechlorethamine in the treatment of psoriasis . Arch Derm 103:272-276, 1971.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Feb 1, 1972

References