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Topical Vitamin A Acid in Acne Vulgaris

Topical Vitamin A Acid in Acne Vulgaris Abstract The therapeutic effectiveness of four local forms of treatment was compared in acne vulgaris: (a) sulfur-resorcinol; (b) benzoyl peroxide; (c) vitamin A acid; and, (d) an inert vehicle. The method of assessment was counting all the lesions on one side of the face at weekly intervals. The order of increasing therapeutic efficacy was: vehicle, sulfur-resorcinol, benzoyl peroxide, and vitamin A acid. Vitamin A acid increased the rate of production of loose horny cells in the follicular canal, thus preventing formation of comedones and unseating existing ones. The treatment frequently produces a worsening of the clinical picture during the initial phase of therapy. It is palliative, not curative; relapses occasionally occur when treatment is stopped. References 1. Straumtjord, J.V.: Vitamin A: Its Effects on Acne , Northwest Med 42:219-225 ( (Aug) ) 1943. 2. Anderson, J.A.D., and Stokoe, I.H.: Vitamin A in Acne Vulgaris , Brit Med J 2:294-296 ( (Aug) ) 1963.Crossref 3. Lynch, F.W., and Cook, C.D.: Acne Vulgaris Treated With Vitamin A , Arch Derm 55:355-357 ( (March) ) 1947.Crossref 4. Mitchell, G.H., and Butterworth, T.: Results of Treatment of Acne Vulgaris by Intramuscular Injections of Vitamin A , Arch Derm 64:428-430 ( (Oct) ) 1951.Crossref 5. Hunter, R., and Pinkus, H.: The Effect of Oral Vitamin A on the Number of Keratin Cells of Human Epidermis , J Invest Derm 37:459-460 ( (Dec) ) 1961.Crossref 6. Fell, H.B., and Mellanby, E.: Metaplasia Produced in Cultures of Chick Ectoderm by High Vitamin A , J Physiol 119:470-488 ( (March) ) 1953. 7. Stimson, W.H.: Vitamin A Intoxication in Adults , New Eng J Med 265:369-373 ( (Aug) ) 1961.Crossref 8. Von Beer, P.: Untersuchungen über die Wirkung der Vitamin-A Saüre , Dermatologica 124:192-195 ( (March) ) 1962.Crossref 9. Stüttgen, C.: Zur Lokalbehandlung von Keratosen mit Vitamin A-Saüre , Dermatologica 124:65-80 ( (Feb) ) 1962.Crossref 10. Frost, P., and Weinstein, G.D.: Topical Vitamin A Acid for Scaling Dermatoses , Clin Res 16:255 (National Meeting Abstracts), 1968. 11. Witkowski, J.A., and Simons, H.M.: Objective Evaluation of Dimethylchlortetracycline HC1 in the Treatment of Acne , JAMA 196:397-400 ( (May) ) 1966.Crossref 12. Weissman, G.; Uhr, J.W.; and Thomas, L.: Acute Hypervitaminosis A in Guinea Pigs , Proc Soc Exper Biol Med 112:284-287 ( (Feb) ) 1963.Crossref 13. Lawrence, D.J., and Bern, H.A.: On the Specificity of the Response of Mouse Epidermis to Vitamin A , J Invest Derm 31:313-325 ( (Dec) ) 1958.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Topical Vitamin A Acid in Acne Vulgaris

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Publisher
American Medical Association
Copyright
Copyright © 1969 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1969.01610220097017
Publisher site
See Article on Publisher Site

Abstract

Abstract The therapeutic effectiveness of four local forms of treatment was compared in acne vulgaris: (a) sulfur-resorcinol; (b) benzoyl peroxide; (c) vitamin A acid; and, (d) an inert vehicle. The method of assessment was counting all the lesions on one side of the face at weekly intervals. The order of increasing therapeutic efficacy was: vehicle, sulfur-resorcinol, benzoyl peroxide, and vitamin A acid. Vitamin A acid increased the rate of production of loose horny cells in the follicular canal, thus preventing formation of comedones and unseating existing ones. The treatment frequently produces a worsening of the clinical picture during the initial phase of therapy. It is palliative, not curative; relapses occasionally occur when treatment is stopped. References 1. Straumtjord, J.V.: Vitamin A: Its Effects on Acne , Northwest Med 42:219-225 ( (Aug) ) 1943. 2. Anderson, J.A.D., and Stokoe, I.H.: Vitamin A in Acne Vulgaris , Brit Med J 2:294-296 ( (Aug) ) 1963.Crossref 3. Lynch, F.W., and Cook, C.D.: Acne Vulgaris Treated With Vitamin A , Arch Derm 55:355-357 ( (March) ) 1947.Crossref 4. Mitchell, G.H., and Butterworth, T.: Results of Treatment of Acne Vulgaris by Intramuscular Injections of Vitamin A , Arch Derm 64:428-430 ( (Oct) ) 1951.Crossref 5. Hunter, R., and Pinkus, H.: The Effect of Oral Vitamin A on the Number of Keratin Cells of Human Epidermis , J Invest Derm 37:459-460 ( (Dec) ) 1961.Crossref 6. Fell, H.B., and Mellanby, E.: Metaplasia Produced in Cultures of Chick Ectoderm by High Vitamin A , J Physiol 119:470-488 ( (March) ) 1953. 7. Stimson, W.H.: Vitamin A Intoxication in Adults , New Eng J Med 265:369-373 ( (Aug) ) 1961.Crossref 8. Von Beer, P.: Untersuchungen über die Wirkung der Vitamin-A Saüre , Dermatologica 124:192-195 ( (March) ) 1962.Crossref 9. Stüttgen, C.: Zur Lokalbehandlung von Keratosen mit Vitamin A-Saüre , Dermatologica 124:65-80 ( (Feb) ) 1962.Crossref 10. Frost, P., and Weinstein, G.D.: Topical Vitamin A Acid for Scaling Dermatoses , Clin Res 16:255 (National Meeting Abstracts), 1968. 11. Witkowski, J.A., and Simons, H.M.: Objective Evaluation of Dimethylchlortetracycline HC1 in the Treatment of Acne , JAMA 196:397-400 ( (May) ) 1966.Crossref 12. Weissman, G.; Uhr, J.W.; and Thomas, L.: Acute Hypervitaminosis A in Guinea Pigs , Proc Soc Exper Biol Med 112:284-287 ( (Feb) ) 1963.Crossref 13. Lawrence, D.J., and Bern, H.A.: On the Specificity of the Response of Mouse Epidermis to Vitamin A , J Invest Derm 31:313-325 ( (Dec) ) 1958.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Apr 1, 1969

References