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Topical Cyclosporine in Alopecia Areata

Topical Cyclosporine in Alopecia Areata Abstract To the Editor.— The recent article by Biren and Barr1 advocates the use of cyclosporine therapy in alopecia areata. We report here our experience with the topical application of the drug. Report of a Case.— A 23-year-old man had had alopecia universalis for three years. He had been successfully treated with oral corticosteroids, but his hair had fallen again after discontinuation of the treatment. After consent, in May 1985, he initiated applying a lotion containing 250 mg of cyclosporine in 80 mL of isopropyl alcohol, 10 mL of propylene glycol, and 15 mL of distilled water once a day to his bald scalp (Fig 1). Since a congenital nevus was present on the vertex, he was advised not to apply the lotion to it.In September 1985, no hair growth was registered, but the patient continued applying the lotion. In March 1986, regrowth was apparent, sparing the nevus of the vertex References 1. Biren CA, Barr RJ: Dermatologic applications of cyclosporine . Arch Dermatol 1986;122:1028-1032.Crossref 2. Biren C, Ganderup G, Lemus L, et al: Topical cyclosporine (CSA): Effect on contact dermatitis in guinea pigs . J Invest Dermatol 1984;82:419. 3. Starzl TE, Porter KA, Iwatsuki S, et al: Reversibility of lymphomas and lymphoproliferative lesions developing under cyclosporine-steroid therapy . Lancet 1984;1:584-587. 4. Mortimer PS, Thompson JF, Dawber RPR: Hypertrichosis and multiple cutaneous squamous cell carcinomas in association with cyclosporin A therapy . J R Soc Med 1983;76:786-787. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Topical Cyclosporine in Alopecia Areata

Archives of Dermatology , Volume 123 (2) – Feb 1, 1987

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Publisher
American Medical Association
Copyright
Copyright © 1987 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1987.01660260033007
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor.— The recent article by Biren and Barr1 advocates the use of cyclosporine therapy in alopecia areata. We report here our experience with the topical application of the drug. Report of a Case.— A 23-year-old man had had alopecia universalis for three years. He had been successfully treated with oral corticosteroids, but his hair had fallen again after discontinuation of the treatment. After consent, in May 1985, he initiated applying a lotion containing 250 mg of cyclosporine in 80 mL of isopropyl alcohol, 10 mL of propylene glycol, and 15 mL of distilled water once a day to his bald scalp (Fig 1). Since a congenital nevus was present on the vertex, he was advised not to apply the lotion to it.In September 1985, no hair growth was registered, but the patient continued applying the lotion. In March 1986, regrowth was apparent, sparing the nevus of the vertex References 1. Biren CA, Barr RJ: Dermatologic applications of cyclosporine . Arch Dermatol 1986;122:1028-1032.Crossref 2. Biren C, Ganderup G, Lemus L, et al: Topical cyclosporine (CSA): Effect on contact dermatitis in guinea pigs . J Invest Dermatol 1984;82:419. 3. Starzl TE, Porter KA, Iwatsuki S, et al: Reversibility of lymphomas and lymphoproliferative lesions developing under cyclosporine-steroid therapy . Lancet 1984;1:584-587. 4. Mortimer PS, Thompson JF, Dawber RPR: Hypertrichosis and multiple cutaneous squamous cell carcinomas in association with cyclosporin A therapy . J R Soc Med 1983;76:786-787.

Journal

Archives of DermatologyAmerican Medical Association

Published: Feb 1, 1987

References