Abstract Significant rises of intraocular pressure have been observed after topical administration of certain corticosteroids.1-10 These changes were noted in all patients with proved open-angle glaucoma, in most open-angle glaucoma suspects, in many relatives of glaucoma patients, and in some normal volunteers. Patients with primary open-angle glaucoma responded to topical steroids with marked pressure elevation. The response appeared to be distributed as a single gaussian population. The pressure rise induced in normal volunteers showed a bimodal or trimodal distribution. On the basis of these observations and the study of the response in families of glaucoma patients, it was postulated that the intraocular response to topical corticosteroid was genetically determined and inherited in dominant fashion.3-10 It was further suggested that patients with primary open-angle glaucoma behave as if they were homozygous for the responsive trait. According to this hypothesis, the steroid provocative test could reveal the heterozygous or carrier state References 1. Francois, J.: Glaucome apparemment simple, secondaire a la cortisonotherapie locale , Ophthalmologica 142:517, 1961. 2. Goldmann, H.: Cortisone Glaucoma , Arch Ophthal , 68:621, 1962. 3. Becker, B., and Mills, D.W.: Corticosteroids and Intraocular Pressure , Arch Ophthal 70:500,1963. 4. Armaly, M.F.: Effect of Corticosteroids on Intraocular Pressure and Fluid Dynamics: I. The Effect of Dexamethasone in the Normal Eye , Arch Ophthal 70:482, 1963. 5. Armaly, M.F.: Effect of Corticosteroids on Intraocular Pressure and Fluid Dynamics: II. The Effect of Dexamethasone in the Glaucomatous Eye , Arch Ophthal 70:492, 1963. 6. Becker, B., and Hahn, K.A.: Topical Corticosteroids and Heredity in Primary Open Angle Glaucoma , Amer J Ophthal 57:543, 1964. 7. Armaly, M.F.: Statistical Attributes of the Steroid Hypertensive Response in the Clinically Normal Eye: I. The Demonstration of Three Levels of Response , Invest Ophthal 4:187, 1965. 8. Becker, B.: Intraocular Pressure Response to Topical Corticosteroids , Invest Ophthal 4:198, 1965. 9. Becker, B., and Ballin, N.: Corticosteroid Provocative Testing , Arch Ophthal 74:621, 1965. 10. Armaly, M.F.: Heritable Nature of Dexamethasone-Induced Ocular Hypertension , Arch Ophthal 75:32, 1966. 11. Becker, B., and Shaffer, R.N.: Diagnosis and Therapy of the Glaucomas , St. Louis: C.V. Mosby Co., 1965, p 107.
Archives of Ophthalmology – American Medical Association
Published: Oct 1, 1966
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