Abstract Several normal and glaucoma suspect populations were studied during four weeks of topical 0.1% dexamethasone prescribed four times daily in either one or both eyes. The difference in tension before and after steroid (Δ Ta) is independent of the initial tension. In 24 glaucoma suspects there was a 79% response (Δ Ta ≧ 6 mm Hg) and in 75 normal white patients there was a 60% response. The difference between these two groups is not significant. There was a lesser response in Negroes than in whites. An important uncontrolled factor was patient motivation in using the drops as prescribed. We suggest that the steroid hypertensive response is a genetic marker that relates to normal and glaucoma patients in a similar manner. References 1. Armaly, M.: Effect of Corticosteroids on Intraocular Pressure and Fluid Dynamics: I. The Effect of Dexamethasone in the Normal Eye ,. Arch Ophthal 70:482, 1963.Crossref 2. Armaly, M.: Effect of Corticosteroid on Intraocular Pressure and Fluid Dynamics: II. The Effect of Dexamethasone in the Glaucomatous Eye , Arch Ophthal 70:492, 1963.Crossref 3. Armaly, M.: Statistical Attributes of the Steroid Hypertensive Response in the Clinically Normal Eye , Invest Ophthal 4:187, 1965. 4. Armaly, M.: Heritable Nature of Dexamethasone-Induced Ocular Hypertension , Arch Ophthal 75:32, 1966.Crossref 5. Armaly, M.: Dexamethasone Ocular Hypertension in the Clinically Normal Eye , Arch Ophthal 75:776, 1966.Crossref 6. Becker, B., and Mills, D.W.: Corticosteroids and Intraocular Pressure , Arch Ophthal 70:500, 1963.Crossref 7. Becker, B., and Hahn, K.A.: Topical Corticosteroids and Heredity in Primary Open-Angle Glaucoma , Amer J Ophthal 57:544, 1964. 8. Becker, B.: Intraocular Pressure Response to Topical Corticosteroids , Invest Ophthal 4:198, 1965. 9. Becker, B., et al: The Intraocular Pressure Response to Topical Corticosteroids in Diabetes , Arch Ophthal 76:477-483, 1966.Crossref 10. Nicholas, J.P.: Topical Corticosteroids and Aqueous Human Dynamics , Arch Ophthal 72:189, 1964.Crossref 11. Miller, D.; Peczan, J.D.; and Whitworth, C.G.: Corticosteroids and Function in the Anterior Segment of the Eye , Amer J Ophthal 59:31, 1965.
Archives of Ophthalmology – American Medical Association
Published: May 1, 1967