Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You and Your Team.

Learn More →

Topical Application of Cyclosporine on Guinea Pig Allergic Contact Dermatitis

Topical Application of Cyclosporine on Guinea Pig Allergic Contact Dermatitis Abstract To the Editor.— We were very interested in the article by Nakagawa et al1 in the June 1988 issue of the Archives, concerning the effect of topical application of cyclosporine A on guinea pig allergic contact dermatitis.1 The authors found the drug to be effective in suppressing skin reactions to dinitrochlorobenzene in previously sensitized animals.On the other hand, a recent study where topical cyclosporine A was used in human allergic contact dermatitis, according to the method standardized by Sukanio et al,2 led us to negative results.We studied 14 patients affected with proven allergic contact dermatitis. Pretreatment of the patch test area with cyclosporine A in different concentrations (0.1% to 1% to 10% in Labrafil) did not lower the intensity of the positive patch test reaction. According to the literature,2 only 0.25% desoxymethasone was able to inhibit the eczematous response to the hapten.3To the References 1. Nakagawa S, Oka D, Jinno Y, Takei Y, Bang D, Veki H. Topical application of cyclosporine on guinea pig allergic contact dermatitis . Arch Dermatol. 1988;124:907-910.Crossref 2. Sukanio H, Nater JP, Bleumink E. Influence of topically applied corticosteroids on patch test reactions . Contact Derm. 1981;7:180-185.Crossref 3. Lembo G, Balato N, Patruno C, Ayala F. Effect of topical cyclosporine A on patch test reaction . Contact Dermatitis . In press. 4. Aldrige RD, Sewell HF, King G, Thomson AW. Topical cyclosporine A in nickel contact hypersensitivity: result of a preliminary clinical and immunohistochemical investigation . Clin Exp Immunol. 1986;66:582-589. 5. Cole GW, Shimomaye S, Goodman M. The effect of topical cyclosporine A on the elicitation phase of allergic contact dermatitis . Contact Dermatitis . 1988;19:129-132.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Topical Application of Cyclosporine on Guinea Pig Allergic Contact Dermatitis

Loading next page...
 
/lp/american-medical-association/topical-application-of-cyclosporine-on-guinea-pig-allergic-contact-gFArb180Yw
Publisher
American Medical Association
Copyright
Copyright © 1989 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1989.01670220129025
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor.— We were very interested in the article by Nakagawa et al1 in the June 1988 issue of the Archives, concerning the effect of topical application of cyclosporine A on guinea pig allergic contact dermatitis.1 The authors found the drug to be effective in suppressing skin reactions to dinitrochlorobenzene in previously sensitized animals.On the other hand, a recent study where topical cyclosporine A was used in human allergic contact dermatitis, according to the method standardized by Sukanio et al,2 led us to negative results.We studied 14 patients affected with proven allergic contact dermatitis. Pretreatment of the patch test area with cyclosporine A in different concentrations (0.1% to 1% to 10% in Labrafil) did not lower the intensity of the positive patch test reaction. According to the literature,2 only 0.25% desoxymethasone was able to inhibit the eczematous response to the hapten.3To the References 1. Nakagawa S, Oka D, Jinno Y, Takei Y, Bang D, Veki H. Topical application of cyclosporine on guinea pig allergic contact dermatitis . Arch Dermatol. 1988;124:907-910.Crossref 2. Sukanio H, Nater JP, Bleumink E. Influence of topically applied corticosteroids on patch test reactions . Contact Derm. 1981;7:180-185.Crossref 3. Lembo G, Balato N, Patruno C, Ayala F. Effect of topical cyclosporine A on patch test reaction . Contact Dermatitis . In press. 4. Aldrige RD, Sewell HF, King G, Thomson AW. Topical cyclosporine A in nickel contact hypersensitivity: result of a preliminary clinical and immunohistochemical investigation . Clin Exp Immunol. 1986;66:582-589. 5. Cole GW, Shimomaye S, Goodman M. The effect of topical cyclosporine A on the elicitation phase of allergic contact dermatitis . Contact Dermatitis . 1988;19:129-132.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Oct 1, 1989

References