Abstract THROUGHOUT the years, the otolaryngologist has been greatly concerned with the innumerable and varied complaints of patients following tonsillectomies. Taking this fact into consideration, we decided to use a potent anti-inflammatory agent with analgesic and antipyretic actions (oxyphenbutazone), in an attempt to determine its value in decreasing the morbidity after this surgical procedure. The effectiveness of this drug to control edema and pain in laryngectomies, adenotonsillectomies, facial fractures of different types, and sinusectomies has been widely demonstrated by many authors: Catalano and Rossi,1 Connell et al,2 Miller et al,3 Neves Pinto,4 and Pinto Zepeda.5 Chemistry The chemical composition of oxyphenbutazone is 1-phenyl-2(p-hydroxyphenyl)-3, 5-dioxo-4-butylpyrazolidine-monohydrate. It is a white powder, soluble in the alkaline medium of the duodenum. It is supplied in round sugar-coated tablets of 100 mg and in suppositories of 250 mg. The absorption is rapid and complete in the duodenum and it References 1. Catalano, G.B., and Rossi, M.: L'impiego dell'ossifenilbutazone (G-27202) nella profilassi chirurgica post operatoria negli interventi di interesse O.R.L , Clin Otolaring 12:383-390 1960. 2. Connell, J.F., and Rousselot, L.M.: The Clinical Evaluation of a New Anti-inflammatory Agent: A Preliminary Report , Amer J Surg 98:31-33 1959.Crossref 3. Miller, J.M., et al: Clinical Experience With Oxyphenbutazone in the Treatment of Inflammation and Edema , Antibiot Med 7:104-114 1960. 4. Neves Pinto, R.M.: Nota preliminar sobre el empleo de G 27202 en Otorrinolaringologia , Rev Bras Med 19:679-681 1962. 5. Pinto Zepeda, J.J.: Tratamiento anti-inflamatorio con oxifenbutazone en traumatologia , Prensa Med Mex 27:430-432 ( (Nov) -Dec) 1962. 6. Teitel, L.H., et al: Oxyphenbutazone , Arch Otolaryng 78:91-95 1963.Crossref 7. Burns, J.J., et al: Phenylbutazone Metabolites: Antirheumatic Sodium Retaining and Uricosuric Effect in Man , J Pharmacol Exp Ther 123:63-69, 1958. 8. Pfister, R., and Hafliger, F.: Ueber Derivative des Phenylbutazons: I. In der Benzolkernen hydroxylierte Derivate , Helv Chim Acta 40:395, 1957.Crossref 9. Barceló, R.; Riopel, P.; and Legreday, L.P.: Effects of Oxyphenbutazone (Tanderil) on Plasma Seromucoids , Canada Med Assoc J 88:562-567, 1963. 10. Domenjoz, R.: The Pharmacology of Phenylbutazone Analogues , Ann NY Acad Sci 86:263, 1960.Crossref
Archives of Otolaryngology – American Medical Association
Published: Feb 1, 1968
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