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Toluidine Blue in the Management of Carcinoma of the Oral Cavity

Toluidine Blue in the Management of Carcinoma of the Oral Cavity Abstract THE EARLY diagnosis and management of carcinoma of the oral cavity and pharynx continues to present a great challenge. Carcinoma in an early stage of development is hard to detect because the lesion may be impalpable and the color changes not very different from the color of the surrounding mucosa. When the tumor is still intraepithelial, the only evidence may be an area of "erosion" where the thin covering layer of keratin or flattened cells is missing. Because carcinoma in the oral cavity, pharynx, and larynx is often multicentric in origin, it is common to find satellite tumors adjacent to the main tumor mass; the satellite tumor may be inconspicuous and overlooked during definitive therapy. Many carcinomas of the oral cavity start out as surface lesions which spread over the mucosa much more than they infiltrate1; the margins of the tumor may be hard to define, especially if there is References 1. Slaughter, D.P.; Southwick, H.W.; and Smejkel, W.: Field Cancerization in Oral Stratified Epithelium , Cancer 6:963-968, 1953.Crossref 2. Richart, R.N.: Clinical Staining Test for in Vivo Delineation of Dysplasia and Carcinoma in Situ , Amer J Obstet Gynec 86:703-712, 1963. 3. Niebel, H.H., and Chomet, B.: In Vivo Staining Test for Delineation of Oral Intra-Epithelial Neoplastic Change , J Amer Dent Assoc 68:801-806, 1964. 4. Shedd, J.P.; Hukill, P.B.; and Bahn, S.: In Vivo Staining Properties of Oral Carcinoma , Amer J Surg 110:631-634, 1965.Crossref 5. Kurnick, N.B.: Histological Staining With Methyl-Green-Pyronin , Stain Tech 27:233-242, 1952. 6. Greep, R.O.: Histology , ed 2, New York: McGraw-Hill Book Co., Inc., 1966, pp 80-81. 7. Chandler, J.R.: The Nonvalue of Oral Cytology , Arch Otolaryng 84:527-533, 1966.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Otolaryngology American Medical Association

Toluidine Blue in the Management of Carcinoma of the Oral Cavity

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Publisher
American Medical Association
Copyright
Copyright © 1968 American Medical Association. All Rights Reserved.
ISSN
0003-9977
DOI
10.1001/archotol.1968.00760060529017
Publisher site
See Article on Publisher Site

Abstract

Abstract THE EARLY diagnosis and management of carcinoma of the oral cavity and pharynx continues to present a great challenge. Carcinoma in an early stage of development is hard to detect because the lesion may be impalpable and the color changes not very different from the color of the surrounding mucosa. When the tumor is still intraepithelial, the only evidence may be an area of "erosion" where the thin covering layer of keratin or flattened cells is missing. Because carcinoma in the oral cavity, pharynx, and larynx is often multicentric in origin, it is common to find satellite tumors adjacent to the main tumor mass; the satellite tumor may be inconspicuous and overlooked during definitive therapy. Many carcinomas of the oral cavity start out as surface lesions which spread over the mucosa much more than they infiltrate1; the margins of the tumor may be hard to define, especially if there is References 1. Slaughter, D.P.; Southwick, H.W.; and Smejkel, W.: Field Cancerization in Oral Stratified Epithelium , Cancer 6:963-968, 1953.Crossref 2. Richart, R.N.: Clinical Staining Test for in Vivo Delineation of Dysplasia and Carcinoma in Situ , Amer J Obstet Gynec 86:703-712, 1963. 3. Niebel, H.H., and Chomet, B.: In Vivo Staining Test for Delineation of Oral Intra-Epithelial Neoplastic Change , J Amer Dent Assoc 68:801-806, 1964. 4. Shedd, J.P.; Hukill, P.B.; and Bahn, S.: In Vivo Staining Properties of Oral Carcinoma , Amer J Surg 110:631-634, 1965.Crossref 5. Kurnick, N.B.: Histological Staining With Methyl-Green-Pyronin , Stain Tech 27:233-242, 1952. 6. Greep, R.O.: Histology , ed 2, New York: McGraw-Hill Book Co., Inc., 1966, pp 80-81. 7. Chandler, J.R.: The Nonvalue of Oral Cytology , Arch Otolaryng 84:527-533, 1966.Crossref

Journal

Archives of OtolaryngologyAmerican Medical Association

Published: May 1, 1968

References

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