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Abstract AVAILABLE evidence suggests that normal brain tissue will not survive a period of total, temporary ischemia exceeding five to seven minutes.1,2 The vulnerability of neoplasms arising from glial cells or other intracranial structures to temporary ischemia has not been extensively evaluated inasmuch as it has been difficult selectively to deprive tumor tissues of blood and then restore circulation at a precise moment. This study was conducted with an experimentally produced glioma in C3H mice which is readily accepted in subcutaneous transplantation by other animals of the strain. Materials and Methods This tumor, an ependymoma, was originally induced by intracerebral implantation of methylcholanthrene after the method of Zimmerman3 by Dr. Dogan Perese of the Roswell Park Institute, Buffalo, New York, who supplied it to this laboratory. It has grown well in subsequent transplantations with no significant change in its histologic picture. For transplantation, a suspension of tumor cells was References 1. Wright, R.L., and Ames, A.: III. Measurement of Maximal Permissible Cerebral Ischemia and a Study of Its Pharmacologic Prolongation , J Neurosurg 21:567-574 ( (July) ) 1964.Crossref 2. Wright, R.L.: Experimental Cerebral Ischemia , Angiology 16:397-404 ( (Feb) ) 1967.Crossref 3. Zimmerman, H.M., and Arnold, H.: Experimental Brain Tumors: I. Tumors Produced With Methylcholanthrene , Cancer Res 1:919-938 ( (Dec) ) 1941. 4. Umbreit, W.W.; Burris, R.H.; and Stauffer, J.F.: Manometric Techniques and Tissue Metabolism , Minneapolis: Burgess Publishing Co., 1949. 5. Wright, R.L., Brownlow, B.; and Keller, J.: The Effect of Glucocorticosteroids on Growth and Metabolism of Experimental Glial Tumors , J Neurosurg , to be published. 6. Warburg, O.: Metabolism of Tumors , London: Constable and Co., Ltd., 1930. 7. Warburg, O.: On the Origin of Cancer Cells , Science 123:309-314 ( (Feb 24) ) 1956.Crossref 8. Dohr, H.: Über die Atmung von menschlichen Hirntumoren und Hirngewächse in vitro , Acta Neurochir 9:543-553 ( (June 12) ) 1961.Crossref 9. Mahaley, M.S., Jr.: The in Vitro Respiration of Normal Brain and Brain Tumors , Cancer Res 26:195-197 ( (Feb) ) 1966. 10. Maker, H.S.; Lehrer, G.M.; and Scheinberg, L.C.: The Effect of Ischemia on Substrates of Carbohydrate Metabolism in an Experimental Glial Tumor and in Brain, read before the American Association of Neuropathologists, Atlantic City, NJ, June 1966. 11. Foley, E.J.: Antigenic Properties of Methylcholanthrene-Induced Tumors in Mice of the Strain of Origin , Cancer Res 13:835-837 ( (Dec) ) 1953. 12. Martinez, C., et al: Continuous Growth of Isotransplants of a Mammary Tumor Associated With the Development of Immunity in Mice , Cancer Res 17:205-207 ( (April) ) 1957. 13. Wilkins, R.H., and Ketcham, A.S.: Studies of Glioma Growth in Mice: II. Immunity After Excision , Arch Neurol 9:671-676 ( (Dec) ) 1963.Crossref
Archives of Neurology – American Medical Association
Published: Sep 1, 1968
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