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Tobacco-Alcohol Amblyopia: Further Comments on Its Pathology

Tobacco-Alcohol Amblyopia: Further Comments on Its Pathology Abstract In the course of our studies of nutritional disorders of the nervous system in a large number of patients with chronic alcoholism, our attention has repeatedly been drawn to a characteristic visual disorder, generally referred to as tobacco-alcohol amblyopia. In 1960, we described in detail the clinical manifestations of this syndrome in 14 patients and the pathological findings in one of them.1 Unfortunately, our account of the pathological findings in that case failed to include the retina, which was unavailable for study. Recently we have had an opportunity to study the retinal pathology of a patient with tobacco-alcohol amblyopia. The medical literature contains very few such cases and virtually none in which modern histological techniques have been used. For this reason, and also because the pathological changes in other parts of the visual pathway proved to be of unusual interest, this case is being presented in some detail. Report References 1. Victor, M.; Mancall, E.L.; and Dreyfus, P.M.: Deficiency Amblyopia in the Alcoholic Patient , Arch Ophthal 64:1, 1960.Crossref 2. Van Buren, J.M.: Retinal Ganglion Cell Layer , Springfield, Ill: Charles C Thomas, Publisher, 1963. 3. Harrington, D.O.: The Visual Fields , St. Louis: C. V. Mosby Co., 1956, pp 186-194. 4. Victor, M.: Tobacco-Alcohol Amblyopia. A Critique of Current Concepts of This Disorder, With Special Reference to the Role of Nutritional Deficiency and Its Causation , Arch Ophthal 70:313, 1963.Crossref 5. Hamilton, H.E.; Ellis, P.P.; and Sheets, R.F.: Visual Impairment due to Optic Neuropathy in Pernicious Anemia , Blood 14:387, 1959. 6. Lerman, S., and Feldmahn, A.L.: Centrocecal Scotoma as the Presenting Sign in Pernicious Anemia , Arch Ophthal 65:381, 1961.Crossref 7. De Schweinitz, G.E.: Toxic Amblyopias , Philadelphia: Lea Brothers and Co., 1896. 8. Ronne, H.: Pathologische anatomische Untersuchungen über Alkoholische Intoxicationsamblyopie , Graefe Arch Ophthal 77:1, 1910.Crossref 9. Friedenwald, H.: The Newer Pathology of the Retina, With Special Reference to the Changes Produced in the Ganglion Cells by Certain Toxic Agents , Ophthal Rec 10: 428, 1901. 10. Knapp. quoted by De Schweinitz.7 11. Uhthoff, W.: Untersuchunger über den Einfluss des chronischen Alkoholismus auf das menschliche Sehorgan , Graefe Arch Ophthal 32:95, 1886.Crossref 12. Samelsohn, J.: Zur Anatomie und Nosologie der Retrobulbaren neuritis (Amblyopia Neuritis) Graefe Arch Ophthal 28:1, 1882.Crossref 13. Sachs, T.: Anatomical and Clinical Contributions to the Knowledge of Central Scotoma in Affection of the Optic Nerve , Arch Ophthal 18:133, 1889. 14. Kupfer, C.: Retinal Ganglion Cell Degeneration Following Chiasmal Lesions in Man , Arch Ophthal 70:256, 1963.Crossref 15. Kupfer, C.: The Projection of the Macula in the Lateral Geniculate Nucleus of Man , Amer J Ophthal 54:597, 1962. 16. Adams, R.D.; Victor, M.; and Mancall, E.L.: Central Pontine Myelinolysis , Arch Neurol 81:154, 1959. 17. Jequier, M., and Wildi, E.: Le Syndrome de Marchiafava-Bignami , Schweiz Arch Neurol Psychiat 77:393, 1956. 18. Seitlberger, F., and Berner, P.: Uber die Markiafavasche Krankheit , Arch Path Anat 326:257, 1955.Crossref 19. Schwob, R. A., et al: Sur trois cas de syndrome confusionnel avec contracture chez des éthyliques. Le probleme des encephalopathies carentielles , Rev Neurol 98:174, 1953. 20. King, L.S., and Meehan, M.C.: Primary Degeneration of the Corpus Callosum (Marchiafava's Disease) . Arch Neurol Psychiat 36:547, 1936.Crossref 21. Orlando, J.C., cited in Jequier and Wildi.15 22. De Schweinitz, G.E.: A case of Toxic Amblyopia With Autopsy and Microscopical Examination of the Specimens , Trans Amer Ophthal Soc 8:186, 1897. 23. Birch-Hirschfeld, A.: Zur Pathogenese der chronischen Nicotinamblyopie , Graefe Arch Ophthal 53:79, 1902.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Tobacco-Alcohol Amblyopia: Further Comments on Its Pathology

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Publisher
American Medical Association
Copyright
Copyright © 1965 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1965.00970040651011
Publisher site
See Article on Publisher Site

Abstract

Abstract In the course of our studies of nutritional disorders of the nervous system in a large number of patients with chronic alcoholism, our attention has repeatedly been drawn to a characteristic visual disorder, generally referred to as tobacco-alcohol amblyopia. In 1960, we described in detail the clinical manifestations of this syndrome in 14 patients and the pathological findings in one of them.1 Unfortunately, our account of the pathological findings in that case failed to include the retina, which was unavailable for study. Recently we have had an opportunity to study the retinal pathology of a patient with tobacco-alcohol amblyopia. The medical literature contains very few such cases and virtually none in which modern histological techniques have been used. For this reason, and also because the pathological changes in other parts of the visual pathway proved to be of unusual interest, this case is being presented in some detail. Report References 1. Victor, M.; Mancall, E.L.; and Dreyfus, P.M.: Deficiency Amblyopia in the Alcoholic Patient , Arch Ophthal 64:1, 1960.Crossref 2. Van Buren, J.M.: Retinal Ganglion Cell Layer , Springfield, Ill: Charles C Thomas, Publisher, 1963. 3. Harrington, D.O.: The Visual Fields , St. Louis: C. V. Mosby Co., 1956, pp 186-194. 4. Victor, M.: Tobacco-Alcohol Amblyopia. A Critique of Current Concepts of This Disorder, With Special Reference to the Role of Nutritional Deficiency and Its Causation , Arch Ophthal 70:313, 1963.Crossref 5. Hamilton, H.E.; Ellis, P.P.; and Sheets, R.F.: Visual Impairment due to Optic Neuropathy in Pernicious Anemia , Blood 14:387, 1959. 6. Lerman, S., and Feldmahn, A.L.: Centrocecal Scotoma as the Presenting Sign in Pernicious Anemia , Arch Ophthal 65:381, 1961.Crossref 7. De Schweinitz, G.E.: Toxic Amblyopias , Philadelphia: Lea Brothers and Co., 1896. 8. Ronne, H.: Pathologische anatomische Untersuchungen über Alkoholische Intoxicationsamblyopie , Graefe Arch Ophthal 77:1, 1910.Crossref 9. Friedenwald, H.: The Newer Pathology of the Retina, With Special Reference to the Changes Produced in the Ganglion Cells by Certain Toxic Agents , Ophthal Rec 10: 428, 1901. 10. Knapp. quoted by De Schweinitz.7 11. Uhthoff, W.: Untersuchunger über den Einfluss des chronischen Alkoholismus auf das menschliche Sehorgan , Graefe Arch Ophthal 32:95, 1886.Crossref 12. Samelsohn, J.: Zur Anatomie und Nosologie der Retrobulbaren neuritis (Amblyopia Neuritis) Graefe Arch Ophthal 28:1, 1882.Crossref 13. Sachs, T.: Anatomical and Clinical Contributions to the Knowledge of Central Scotoma in Affection of the Optic Nerve , Arch Ophthal 18:133, 1889. 14. Kupfer, C.: Retinal Ganglion Cell Degeneration Following Chiasmal Lesions in Man , Arch Ophthal 70:256, 1963.Crossref 15. Kupfer, C.: The Projection of the Macula in the Lateral Geniculate Nucleus of Man , Amer J Ophthal 54:597, 1962. 16. Adams, R.D.; Victor, M.; and Mancall, E.L.: Central Pontine Myelinolysis , Arch Neurol 81:154, 1959. 17. Jequier, M., and Wildi, E.: Le Syndrome de Marchiafava-Bignami , Schweiz Arch Neurol Psychiat 77:393, 1956. 18. Seitlberger, F., and Berner, P.: Uber die Markiafavasche Krankheit , Arch Path Anat 326:257, 1955.Crossref 19. Schwob, R. A., et al: Sur trois cas de syndrome confusionnel avec contracture chez des éthyliques. Le probleme des encephalopathies carentielles , Rev Neurol 98:174, 1953. 20. King, L.S., and Meehan, M.C.: Primary Degeneration of the Corpus Callosum (Marchiafava's Disease) . Arch Neurol Psychiat 36:547, 1936.Crossref 21. Orlando, J.C., cited in Jequier and Wildi.15 22. De Schweinitz, G.E.: A case of Toxic Amblyopia With Autopsy and Microscopical Examination of the Specimens , Trans Amer Ophthal Soc 8:186, 1897. 23. Birch-Hirschfeld, A.: Zur Pathogenese der chronischen Nicotinamblyopie , Graefe Arch Ophthal 53:79, 1902.Crossref

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Nov 1, 1965

References