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Titered Lots of Immune Globulin (Ig): Efficacy in the Prevention of Rubella

Titered Lots of Immune Globulin (Ig): Efficacy in the Prevention of Rubella Abstract ALTHOUGH it appears that live, attenuated rubella vaccines will soon be available for general use, the problem of providing direct protection to the present susceptible, child-bearing-age female population remains. Use of immune globulin (IG) as a method to protect the exposed pregnant woman is controversial.1 Conflicting opinion on the effect IG has against rubella infection1-7 undoubtedly reflects the interplay of several factors, ie, dose of IG, variation in antibody titer of IG lots, time of administration of IG in relation to time of exposure to virus, immune status of the woman at the time of exposure, lack of laboratory-confirmed diagnosis of clinical impressions that an illness is indeed rubella, and the high rate (50% or greater) of subclinical rubella. The primary goal of IG administration is to prevent the teratogenic effects of the rubella virus. Because of the previously-mentioned factors, it is difficult to design well-controlled studies to References 1. Schiff, G.M., and Sever, J.L.: Rubella: Recent Laboratory and Clinical Advances , Progr Med Virol 8:30-61, 1966. 2. Lock, F.R., et al: Incidence of Anomalous Development Following Maternal Rubella: Effect of Clinical Infection or Exposure and Treatment With Gamma Globulin , Amer J Obstet Gynec 81:451-464 ( (March) ) 1961. 3. Korns, R.F.: Prophylaxis of German Measles With Immune Serum Globulin , J Infect Dis 90:183-189 ( (March) -April) 1952.Crossref 4. Grayston, J.T., and Watten, R.H.: Epidemic Rubella in Taiwan, 1957-1958: III. Gamma Globulin in the Prevention of Rubella , New Eng J Med 261: 1145-1150 ( (Dec 3) ) 1959.Crossref 5. Lundstrom, R.: Rubella During Pregnancy: A Follow-up Study of Children Born After an Epidemic of Rubella in Sweden, 1951, With Additional Investigations on Prophylaxis and Treatment of Maternal Rubella , Acta Paediat 51 (suppl 133):1-110 ( (May) ) 1962.Crossref 6. Doege, T.C., and Kim, K.S.: Studies of Rubella and Its Prevention With Immune Globulin , JAMA 200:584-590 ( (May 15) ) 1967.Crossref 7. Green, R.H., et al: Studies on the Experimental Transmission, Clinical Course, Epidemiology, and Prevention of Rubella , Trans Assoc Amer Physicians 77:118-125, 1964. 8. Schiff, G.M.; Sever, J.L.; and Huebner, R.J.: Experimental Rubella: Clinical and Laboratory Findings , Arch Intern Med 116:537-543 ( (Oct) ) 1965.Crossref 9. Sever, J.L., et al: Rubella Epidemic on St. Paul Island in the Pribilofs, 1963: II. Clinical and Laboratory Findings for the Intensive Study Population , JAMA 191:624-626 ( (Feb 22) ) 1965.Crossref 10. Schiff, G.M.; Sever, J.L.; and Huebner, R.J.: Rubella Virus; Neutralizing Antibody in Commercial Gamma Globulin , Science 142:58-60 ( (Oct 4) ) 1963.Crossref 11. Stewart, G.L., et al: Rubella-Virus Hemagglutination-Inhibition Test , New Eng J Med 276: 554-557 ( (March 9) ) 1967.Crossref 12. Green, R.H., et al: Studies of the Natural History and Prevention of Rubella , Amer J Dis Child 110:348-365 ( (Oct) ) 1965.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Titered Lots of Immune Globulin (Ig): Efficacy in the Prevention of Rubella

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Publisher
American Medical Association
Copyright
Copyright © 1969 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1969.02100040324029
Publisher site
See Article on Publisher Site

Abstract

Abstract ALTHOUGH it appears that live, attenuated rubella vaccines will soon be available for general use, the problem of providing direct protection to the present susceptible, child-bearing-age female population remains. Use of immune globulin (IG) as a method to protect the exposed pregnant woman is controversial.1 Conflicting opinion on the effect IG has against rubella infection1-7 undoubtedly reflects the interplay of several factors, ie, dose of IG, variation in antibody titer of IG lots, time of administration of IG in relation to time of exposure to virus, immune status of the woman at the time of exposure, lack of laboratory-confirmed diagnosis of clinical impressions that an illness is indeed rubella, and the high rate (50% or greater) of subclinical rubella. The primary goal of IG administration is to prevent the teratogenic effects of the rubella virus. Because of the previously-mentioned factors, it is difficult to design well-controlled studies to References 1. Schiff, G.M., and Sever, J.L.: Rubella: Recent Laboratory and Clinical Advances , Progr Med Virol 8:30-61, 1966. 2. Lock, F.R., et al: Incidence of Anomalous Development Following Maternal Rubella: Effect of Clinical Infection or Exposure and Treatment With Gamma Globulin , Amer J Obstet Gynec 81:451-464 ( (March) ) 1961. 3. Korns, R.F.: Prophylaxis of German Measles With Immune Serum Globulin , J Infect Dis 90:183-189 ( (March) -April) 1952.Crossref 4. Grayston, J.T., and Watten, R.H.: Epidemic Rubella in Taiwan, 1957-1958: III. Gamma Globulin in the Prevention of Rubella , New Eng J Med 261: 1145-1150 ( (Dec 3) ) 1959.Crossref 5. Lundstrom, R.: Rubella During Pregnancy: A Follow-up Study of Children Born After an Epidemic of Rubella in Sweden, 1951, With Additional Investigations on Prophylaxis and Treatment of Maternal Rubella , Acta Paediat 51 (suppl 133):1-110 ( (May) ) 1962.Crossref 6. Doege, T.C., and Kim, K.S.: Studies of Rubella and Its Prevention With Immune Globulin , JAMA 200:584-590 ( (May 15) ) 1967.Crossref 7. Green, R.H., et al: Studies on the Experimental Transmission, Clinical Course, Epidemiology, and Prevention of Rubella , Trans Assoc Amer Physicians 77:118-125, 1964. 8. Schiff, G.M.; Sever, J.L.; and Huebner, R.J.: Experimental Rubella: Clinical and Laboratory Findings , Arch Intern Med 116:537-543 ( (Oct) ) 1965.Crossref 9. Sever, J.L., et al: Rubella Epidemic on St. Paul Island in the Pribilofs, 1963: II. Clinical and Laboratory Findings for the Intensive Study Population , JAMA 191:624-626 ( (Feb 22) ) 1965.Crossref 10. Schiff, G.M.; Sever, J.L.; and Huebner, R.J.: Rubella Virus; Neutralizing Antibody in Commercial Gamma Globulin , Science 142:58-60 ( (Oct 4) ) 1963.Crossref 11. Stewart, G.L., et al: Rubella-Virus Hemagglutination-Inhibition Test , New Eng J Med 276: 554-557 ( (March 9) ) 1967.Crossref 12. Green, R.H., et al: Studies of the Natural History and Prevention of Rubella , Amer J Dis Child 110:348-365 ( (Oct) ) 1965.Crossref

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Aug 1, 1969

References