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Tinea Versicolor

Tinea Versicolor Abstract To the Editor.— Tinea versicolor (TV) is defined as an eruption of tan or brown patches on the skin caused by the fungus Malassezia furfur. A report in the literature that a tyrosine inhibitor was identified in cultures of TV with certain lipid additives stimulated an investigation of hypopigmented and hyperpigmented variants using light microscopic techniques and tissue culture incubation with sterile olive oil as an additive.1 When these studies did not reveal any significant differences between the variants, it was decided to study the samples at the ultrastructural level with transmission electron microscopy. Subjects and Methods.— Ten biopsy specimens were obtained for study. Six of these were from the back of one black patient. They were obtained from three control unaffected areas, two hyperpigmented areas, and one hypovariant area. In addition, biopsy specimens of control and hypovariant areas were obtained from a white patient, and biopsy specimens of control and hypervariant areas were obtained from a black patient. All samples were fixed in 2% glutaraldehyde, buffered with cacodylate (pH, 7.4), dehydrated, and embedded in epoxy resin (Epon-Araldite). References 1. Nazzaro Porro M, Passi S: Identification of tyrosinase inhibitors in cultures of Pityrosporum . J Invest Dermatol 1978;71:205.Crossref 2. Winkelmann RK, Breathnach AS: The Merkel cell . J Invest Dermatol 1973;60:2-15.Crossref 3. Allen HB, Charles CR, Johnson BL: Hyperpigmented tinea versicolor . Arch Dermatol 1976;112:1110-1112.Crossref 4. Olson RL, Gaylor J, Everett MA: Skin color, melanin, and erythema . Arch Dermatol 1973;108:541-544.Crossref 5. Konrad K, Wolff K: Hyperpigmentation, melanosome size, and distribution patterns of melanosomes . Arch Dermatol 1973;107:853-860.Crossref 6. Dotz WI, Henrikson DM, Yu GSM, et al: Tinea versicolor: A light and electron microscopic study of hyperpigmented skin . J Am Acad Dermatol 1985;12:37-44.Crossref 7. Saurat JH, Didierjean L: The epidermal Merkel cell is an epithelial cell . Dermatologica 1984;169:117-120.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

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Publisher
American Medical Association
Copyright
Copyright © 1988 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1988.01670040012008
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor.— Tinea versicolor (TV) is defined as an eruption of tan or brown patches on the skin caused by the fungus Malassezia furfur. A report in the literature that a tyrosine inhibitor was identified in cultures of TV with certain lipid additives stimulated an investigation of hypopigmented and hyperpigmented variants using light microscopic techniques and tissue culture incubation with sterile olive oil as an additive.1 When these studies did not reveal any significant differences between the variants, it was decided to study the samples at the ultrastructural level with transmission electron microscopy. Subjects and Methods.— Ten biopsy specimens were obtained for study. Six of these were from the back of one black patient. They were obtained from three control unaffected areas, two hyperpigmented areas, and one hypovariant area. In addition, biopsy specimens of control and hypovariant areas were obtained from a white patient, and biopsy specimens of control and hypervariant areas were obtained from a black patient. All samples were fixed in 2% glutaraldehyde, buffered with cacodylate (pH, 7.4), dehydrated, and embedded in epoxy resin (Epon-Araldite). References 1. Nazzaro Porro M, Passi S: Identification of tyrosinase inhibitors in cultures of Pityrosporum . J Invest Dermatol 1978;71:205.Crossref 2. Winkelmann RK, Breathnach AS: The Merkel cell . J Invest Dermatol 1973;60:2-15.Crossref 3. Allen HB, Charles CR, Johnson BL: Hyperpigmented tinea versicolor . Arch Dermatol 1976;112:1110-1112.Crossref 4. Olson RL, Gaylor J, Everett MA: Skin color, melanin, and erythema . Arch Dermatol 1973;108:541-544.Crossref 5. Konrad K, Wolff K: Hyperpigmentation, melanosome size, and distribution patterns of melanosomes . Arch Dermatol 1973;107:853-860.Crossref 6. Dotz WI, Henrikson DM, Yu GSM, et al: Tinea versicolor: A light and electron microscopic study of hyperpigmented skin . J Am Acad Dermatol 1985;12:37-44.Crossref 7. Saurat JH, Didierjean L: The epidermal Merkel cell is an epithelial cell . Dermatologica 1984;169:117-120.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Apr 1, 1988

References