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Timolol: A β-Adrenergic Blocking Agent for the Treatment of Glaucoma

Timolol: A β-Adrenergic Blocking Agent for the Treatment of Glaucoma Abstract • Timolol maleate, a β-adrenergic blocking agent, was studied in 30 patients With glaucoma. Significant intraocular pressure lowering was achieved with 0.5% and 1.5% solution of the drug. At seven hours following treatment, the IOP was lowered 50% from the pretreatment pressure with both strengths of timolol. There Were no subjective or objective ocular or systemic side effects detected. Visual acuity and pupil response were unchanged from pretreatment levels throughout the study. β-Adrenergic blocking agents and specifically timolol may be an important breakthrough for the medical management of glaucoma. (Arch Ophthalmol 95:601-604, 1977) References 1. Merck Sharp & Dohme Research Laboratories: Preclinical Brochure on Timolol, 1974. 2. Katz IM, Hubbard WA, Getson AJ, et al: Intraocular pressure decrease in normal volunteers following timolol ophthalmic solution . Invest Ophthalmol 15:489-492, 1976. 3. Phillips CI, Howitt G, Rowlands DJ: Propranolol as ocular hypotensive agent . Br J Ophthalmol 51:222-226, 1967.Crossref 4. Cote G, Drance SM: The effect of propranolol on human intraocular pressure . Can J Ophthalmol 3:207-212, 1968. 5. Vale J, Phillips CI: Effect of DL- and Dpropranolol on ocular tension in rabbits and patients . Exp Eye Res 9:82-90, 1970.Crossref 6. Vale J, Gibbs ACC, Phillips CJ: Topical propranolol and ocular tension in the human Br J Ophthalmol 56:770-775, 1972.Crossref 7. Bietti G: Recent experimental, clinical, and therapeutic research on the problems of intraocular pressure and glaucoma . Am J Ophthalmol 73:475-500, 1972. 8. Bonomi L, Steindler P: Effect of pindolol on intraocular pressure . Br J Ophthalmol 59:301-303, 1975.Crossref 9. Elliot MJ, Cullen PM, Phillips CJ: Ocular hypotensive effect of atenolol (Tenormin, I.C.I.): A new β-adrenergic . Br J Ophthalmol 59:296-300, 1975.Crossref 10. Wright P: Skin reactions to practolol . Br Med J 2:560, 1974.Crossref 11. Felix RH, Ive FA, Dahl MGC: Cutaneous and ocular reactions to practolol . Br Med J 4:321, 1974.Crossref 12. Bucci MG, Romini E: Indagine tonografica sull'azione ipotonizzante oculare del propanololo . Boll Ocul 51:255, 1972. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Timolol: A β-Adrenergic Blocking Agent for the Treatment of Glaucoma

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Publisher
American Medical Association
Copyright
Copyright © 1977 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1977.04450040067008
Publisher site
See Article on Publisher Site

Abstract

Abstract • Timolol maleate, a β-adrenergic blocking agent, was studied in 30 patients With glaucoma. Significant intraocular pressure lowering was achieved with 0.5% and 1.5% solution of the drug. At seven hours following treatment, the IOP was lowered 50% from the pretreatment pressure with both strengths of timolol. There Were no subjective or objective ocular or systemic side effects detected. Visual acuity and pupil response were unchanged from pretreatment levels throughout the study. β-Adrenergic blocking agents and specifically timolol may be an important breakthrough for the medical management of glaucoma. (Arch Ophthalmol 95:601-604, 1977) References 1. Merck Sharp & Dohme Research Laboratories: Preclinical Brochure on Timolol, 1974. 2. Katz IM, Hubbard WA, Getson AJ, et al: Intraocular pressure decrease in normal volunteers following timolol ophthalmic solution . Invest Ophthalmol 15:489-492, 1976. 3. Phillips CI, Howitt G, Rowlands DJ: Propranolol as ocular hypotensive agent . Br J Ophthalmol 51:222-226, 1967.Crossref 4. Cote G, Drance SM: The effect of propranolol on human intraocular pressure . Can J Ophthalmol 3:207-212, 1968. 5. Vale J, Phillips CI: Effect of DL- and Dpropranolol on ocular tension in rabbits and patients . Exp Eye Res 9:82-90, 1970.Crossref 6. Vale J, Gibbs ACC, Phillips CJ: Topical propranolol and ocular tension in the human Br J Ophthalmol 56:770-775, 1972.Crossref 7. Bietti G: Recent experimental, clinical, and therapeutic research on the problems of intraocular pressure and glaucoma . Am J Ophthalmol 73:475-500, 1972. 8. Bonomi L, Steindler P: Effect of pindolol on intraocular pressure . Br J Ophthalmol 59:301-303, 1975.Crossref 9. Elliot MJ, Cullen PM, Phillips CJ: Ocular hypotensive effect of atenolol (Tenormin, I.C.I.): A new β-adrenergic . Br J Ophthalmol 59:296-300, 1975.Crossref 10. Wright P: Skin reactions to practolol . Br Med J 2:560, 1974.Crossref 11. Felix RH, Ive FA, Dahl MGC: Cutaneous and ocular reactions to practolol . Br Med J 4:321, 1974.Crossref 12. Bucci MG, Romini E: Indagine tonografica sull'azione ipotonizzante oculare del propanololo . Boll Ocul 51:255, 1972.

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Apr 1, 1977

References