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Time to Focus on the Locus

Time to Focus on the Locus EDITORIAL LINICOPATHOLOGIC EXAMINATION of hu- tion of extensive, extranigral, dopaminergic, and nondo- man brains is the traditional starting paminergic pathologies in the thalamus in PD provide point for our understanding of disease examples of how potentially critical neuropathologic sub- pathophysiology, disease treatment, and strates of disease can be long overlooked. Noninvasive neu- C the functional-anatomical organization roimaging techniques such as positron emission tomog- of the brain. In this issue of the ARCHIVES, Zarow et al raphy with ligands specific to noradrenergic axons or report major cell loss in the brainstem, noradrenergic lo- receptors would be important avenues to explore in de- cus coeruleus (LC), in brains from patients with Alzhei- tecting disease-specific pathologies and their rate of pro- mer disease (AD) and Parkinson disease (PD) com- gression, repeated in cases of AD and PD. pared with healthy controls. The findings are, per se, not Going forward, it would be interesting to establish surprising as LC pathology has been previously docu- those clinical features that might differentiate patients with mented in experimental and idiopathic parkinsonism. AD and PD with LC pathology from those without (eg, co- morbid depression, disordered sleep, or inattentiveness). This will be challenging for reasons enumerated herein http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Neurology American Medical Association

Time to Focus on the Locus

JAMA Neurology , Volume 60 (3) – Mar 1, 2003

Time to Focus on the Locus

Abstract

EDITORIAL LINICOPATHOLOGIC EXAMINATION of hu- tion of extensive, extranigral, dopaminergic, and nondo- man brains is the traditional starting paminergic pathologies in the thalamus in PD provide point for our understanding of disease examples of how potentially critical neuropathologic sub- pathophysiology, disease treatment, and strates of disease can be long overlooked. Noninvasive neu- C the functional-anatomical organization roimaging techniques such as positron emission tomog- of the...
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Publisher
American Medical Association
Copyright
Copyright 2003 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6149
eISSN
2168-6157
DOI
10.1001/archneur.60.3.320
Publisher site
See Article on Publisher Site

Abstract

EDITORIAL LINICOPATHOLOGIC EXAMINATION of hu- tion of extensive, extranigral, dopaminergic, and nondo- man brains is the traditional starting paminergic pathologies in the thalamus in PD provide point for our understanding of disease examples of how potentially critical neuropathologic sub- pathophysiology, disease treatment, and strates of disease can be long overlooked. Noninvasive neu- C the functional-anatomical organization roimaging techniques such as positron emission tomog- of the brain. In this issue of the ARCHIVES, Zarow et al raphy with ligands specific to noradrenergic axons or report major cell loss in the brainstem, noradrenergic lo- receptors would be important avenues to explore in de- cus coeruleus (LC), in brains from patients with Alzhei- tecting disease-specific pathologies and their rate of pro- mer disease (AD) and Parkinson disease (PD) com- gression, repeated in cases of AD and PD. pared with healthy controls. The findings are, per se, not Going forward, it would be interesting to establish surprising as LC pathology has been previously docu- those clinical features that might differentiate patients with mented in experimental and idiopathic parkinsonism. AD and PD with LC pathology from those without (eg, co- morbid depression, disordered sleep, or inattentiveness). This will be challenging for reasons enumerated herein

Journal

JAMA NeurologyAmerican Medical Association

Published: Mar 1, 2003

References