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Time to End Steroid-Induced Fractures

Time to End Steroid-Induced Fractures EDITORIAL LUCOCORTICOID drugs such as predni- considered at the time that steroid treatment is begun, sone are life-saving medications in many particularly in those older than 50 years. inflammatory conditions, including In addition to the clinical risk factors mentioned in those involving the skin. They cause few the previous paragraph, bone density is also an impor- G adverse effects when used over periods tant predictor of fracture and should be assessed in all of days to weeks, but longer-term use (several months patients undergoing long-term treatment with steroids. or longer) produces adverse changes in many tissues. Bone loss tends to be more rapid in the spine than else- These risks include truncal obesity, thinning of the skin, where, so this is usually the preferred measurement site, easy bruising, hypertension, diabetes, adrenal gland sup- using dual-energy x-ray absorptiometry (DXA) or quan- pression, increased susceptibility to infection, cataracts, titative computed tomography. In individuals older than and osteoporosis. These complications most commonly 60 years, spinal arthritis degrades the reliability of spine occur when glucocorticoids are administered systemi- DXA measurements, so assessment in the proximal fe- cally in supraphysiological doses (equivalent to .5 mg/d mur (by DXA) should also be undertaken. Since the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Dermatology American Medical Association

Time to End Steroid-Induced Fractures

JAMA Dermatology , Volume 137 (4) – Apr 1, 2001

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Publisher
American Medical Association
Copyright
Copyright 2001 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6068
eISSN
2168-6084
DOI
10-1001/pubs.Arch Dermatol.-ISSN-0003-987x-137-4-ded00015
Publisher site
See Article on Publisher Site

Abstract

EDITORIAL LUCOCORTICOID drugs such as predni- considered at the time that steroid treatment is begun, sone are life-saving medications in many particularly in those older than 50 years. inflammatory conditions, including In addition to the clinical risk factors mentioned in those involving the skin. They cause few the previous paragraph, bone density is also an impor- G adverse effects when used over periods tant predictor of fracture and should be assessed in all of days to weeks, but longer-term use (several months patients undergoing long-term treatment with steroids. or longer) produces adverse changes in many tissues. Bone loss tends to be more rapid in the spine than else- These risks include truncal obesity, thinning of the skin, where, so this is usually the preferred measurement site, easy bruising, hypertension, diabetes, adrenal gland sup- using dual-energy x-ray absorptiometry (DXA) or quan- pression, increased susceptibility to infection, cataracts, titative computed tomography. In individuals older than and osteoporosis. These complications most commonly 60 years, spinal arthritis degrades the reliability of spine occur when glucocorticoids are administered systemi- DXA measurements, so assessment in the proximal fe- cally in supraphysiological doses (equivalent to .5 mg/d mur (by DXA) should also be undertaken. Since the

Journal

JAMA DermatologyAmerican Medical Association

Published: Apr 1, 2001

References