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Thyroxin and Triiodothyronine in Excessive Dosage to Euthyroid Humans

Thyroxin and Triiodothyronine in Excessive Dosage to Euthyroid Humans Abstract The comparative effects of 3,5,3'-l-triiodothyronine and l-thyroxin in myxedema have been carefully evaluated.1 These medications have also been given in physiologic dosage to euthyroid humans to evaluate the effect on the thyroid I131 uptake and serum protein-bound iodine (PBI).2 We have found no information on the comparative effects of "thyrotoxic" dosage of these drugs and the subsequent effect of stopping these medications. In the course of an evaluation of the effects of induced thyrotoxicosis on mental function,3 interesting new data were accumulated on this aspect of thyroid hormone effect. Method Subjects. —Eighteen healthy male college students ranging in age from 20 to 30 years—average age, 23 years—were screened by medical history, physical examination, 24-hour I131-uptake test, basal metabolic rate (BMR), serum PBI,4 and serum cholesterol5 determination to rule out any question of thyroid disease and to make certain that they could withstand the effects of administration of excessive amounts of References 1. Thyroxin was supplied by Travenol Laboratories, Inc., and triiodothyronine, by Smith, Kline & French Laboratories. 2. Asper, S. P., Jr.; Selenkow, H. A., and Plamondon, C. A.: A Comparison of the Metabolic Activities of 3,5,3'-1-Triiodothyronine and 1-thyroxine in Myxedema , Bull. John Hopkins Hosp. 93:164, 1953. 3. Starr, P., and Liebhold-Schueck, R.: Theory of Thyroid Hormone Action: Conclusions Derived from Differences in Effect of Sodium 1-Thyroxine, Sodium d-Thyroxine, Triiodothyronine, and Potassium Iodide on Upstake of Radioactive Iodine by Thyroid Gland of Normal Human Subjects , A. M. A. Arch. Int. Med. 92:880, 1953.Crossref 4. Ruff, G. E.; Mann, R. D.; Beierwaltes, W. H.; Gerard, R. A.; Kelly, E. L., and Miller, J. G.: Mental Changes in Experimental Hyperthyroidism , to be published. 5. Barker, S. B.; Humphrey, M. J., and Soley, M. H.: The Clinical Determination of Protein-Bound Iodine , J. Clin. Invest. 30:55, 1951.Crossref 6. Sperry, W. M., and Webb, M.: A Revision of the Schoenheimer-Sperry Method for Cholesterol Determination , J. Biol. Chem. 187:97, 1950. 7. McConahey, W. M., and Owen, C. A., Jr.: Studies of the Inhibitory Effect of 1-Triiodothyronine on Thyroidal I181 Uptake in Euthyroid Persons and Patients with Exopthalmic Goiter , J. Clin. Endocrinol. 16:1480, 1956.Crossref 8. Riggs, D. S.; Man, E. B., and Winkler, A.: Serum Iodine of Euthyroid Subjects Treated with Desiccated Thyroid , J. Clin. Invest. 24:722, 1945.Crossref 9. Winkler, A. W.; Riggs, D. S., and Man, E. B.: Serum Iodine in Hypothyroidism Before and During Thyroid Therapy , J. Clin. Invest. 24:732, 1945.Crossref 10. Robertson, J. D., and Kirkpatrick, H. F. W.: Changes in Basal Metabolism, Serum-Protein-Bound Iodine, and Cholesterol During Treatment of Hypothyroidism with Oral Thyroid and 1-Thyroxine Sodium , Brit. M. J. 1:624, 1952.Crossref 11. Michel, R.: Recent Progress in the Physiology and Biochemistry of Thyroid Hormones , Am. J. Med. 20:670, 1956.Crossref 12. Selenkow, H. A., and Asper, S. P., Jr.: The Effectiveness of Triiodothyronine or Thyroxine Administered Orally in the Treatment of Myxedema , J. Clin. Endocrinol. 15:285, 1955.Crossref 13. Greer, M. A.: The Effect on Endogenous Thyroid Activity of Feeding Desiccated Thyroid to Normal Human Subjects , New England J. Med. 244:385, 1951.Crossref 14. Beierwaltes, W. H.: Response to Thyroid, Editorial , J. Clin. Endocrinol. 15:148, 1955.Crossref 15. Tata, J. R.; Rall, J. E., and Rawson, R. W.: Metabolism of 1-Thyroxine and 1-3:5:3'-Triiodothyronine by Brain Tissue Praparations , Endocrinology 60:83, 1957.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Internal Medicine American Medical Association

Thyroxin and Triiodothyronine in Excessive Dosage to Euthyroid Humans

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References (15)

Publisher
American Medical Association
Copyright
Copyright © 1958 American Medical Association. All Rights Reserved.
ISSN
0888-2479
DOI
10.1001/archinte.1958.00260150057007
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Abstract

Abstract The comparative effects of 3,5,3'-l-triiodothyronine and l-thyroxin in myxedema have been carefully evaluated.1 These medications have also been given in physiologic dosage to euthyroid humans to evaluate the effect on the thyroid I131 uptake and serum protein-bound iodine (PBI).2 We have found no information on the comparative effects of "thyrotoxic" dosage of these drugs and the subsequent effect of stopping these medications. In the course of an evaluation of the effects of induced thyrotoxicosis on mental function,3 interesting new data were accumulated on this aspect of thyroid hormone effect. Method Subjects. —Eighteen healthy male college students ranging in age from 20 to 30 years—average age, 23 years—were screened by medical history, physical examination, 24-hour I131-uptake test, basal metabolic rate (BMR), serum PBI,4 and serum cholesterol5 determination to rule out any question of thyroid disease and to make certain that they could withstand the effects of administration of excessive amounts of References 1. Thyroxin was supplied by Travenol Laboratories, Inc., and triiodothyronine, by Smith, Kline & French Laboratories. 2. Asper, S. P., Jr.; Selenkow, H. A., and Plamondon, C. A.: A Comparison of the Metabolic Activities of 3,5,3'-1-Triiodothyronine and 1-thyroxine in Myxedema , Bull. John Hopkins Hosp. 93:164, 1953. 3. Starr, P., and Liebhold-Schueck, R.: Theory of Thyroid Hormone Action: Conclusions Derived from Differences in Effect of Sodium 1-Thyroxine, Sodium d-Thyroxine, Triiodothyronine, and Potassium Iodide on Upstake of Radioactive Iodine by Thyroid Gland of Normal Human Subjects , A. M. A. Arch. Int. Med. 92:880, 1953.Crossref 4. Ruff, G. E.; Mann, R. D.; Beierwaltes, W. H.; Gerard, R. A.; Kelly, E. L., and Miller, J. G.: Mental Changes in Experimental Hyperthyroidism , to be published. 5. Barker, S. B.; Humphrey, M. J., and Soley, M. H.: The Clinical Determination of Protein-Bound Iodine , J. Clin. Invest. 30:55, 1951.Crossref 6. Sperry, W. M., and Webb, M.: A Revision of the Schoenheimer-Sperry Method for Cholesterol Determination , J. Biol. Chem. 187:97, 1950. 7. McConahey, W. M., and Owen, C. A., Jr.: Studies of the Inhibitory Effect of 1-Triiodothyronine on Thyroidal I181 Uptake in Euthyroid Persons and Patients with Exopthalmic Goiter , J. Clin. Endocrinol. 16:1480, 1956.Crossref 8. Riggs, D. S.; Man, E. B., and Winkler, A.: Serum Iodine of Euthyroid Subjects Treated with Desiccated Thyroid , J. Clin. Invest. 24:722, 1945.Crossref 9. Winkler, A. W.; Riggs, D. S., and Man, E. B.: Serum Iodine in Hypothyroidism Before and During Thyroid Therapy , J. Clin. Invest. 24:732, 1945.Crossref 10. Robertson, J. D., and Kirkpatrick, H. F. W.: Changes in Basal Metabolism, Serum-Protein-Bound Iodine, and Cholesterol During Treatment of Hypothyroidism with Oral Thyroid and 1-Thyroxine Sodium , Brit. M. J. 1:624, 1952.Crossref 11. Michel, R.: Recent Progress in the Physiology and Biochemistry of Thyroid Hormones , Am. J. Med. 20:670, 1956.Crossref 12. Selenkow, H. A., and Asper, S. P., Jr.: The Effectiveness of Triiodothyronine or Thyroxine Administered Orally in the Treatment of Myxedema , J. Clin. Endocrinol. 15:285, 1955.Crossref 13. Greer, M. A.: The Effect on Endogenous Thyroid Activity of Feeding Desiccated Thyroid to Normal Human Subjects , New England J. Med. 244:385, 1951.Crossref 14. Beierwaltes, W. H.: Response to Thyroid, Editorial , J. Clin. Endocrinol. 15:148, 1955.Crossref 15. Tata, J. R.; Rall, J. E., and Rawson, R. W.: Metabolism of 1-Thyroxine and 1-3:5:3'-Triiodothyronine by Brain Tissue Praparations , Endocrinology 60:83, 1957.Crossref

Journal

A.M.A. Archives of Internal Medicine – American Medical Association

Published: Mar 1, 1958

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