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Abstract • Exposure of the thyroid gland to ionizing radiation has been associated with a variety of abnormalities. Among these are tardive hypothyroidism and an increased risk of developing thyroid nodules and cancer. Although acute thyroiditis has been known to complicate radioactive iodine 131 therapy, it has rarely been associated with external beam irradiation. Thyrotoxic painless thyroiditis developed in two patients after mantle-field irradiation for Hodgkin's disease. (Arch Intern Med 1985;145:1734-1735) References 1. Poussin-Rosillo H, Nisce LZ, Lee BJ: Complications of total nodal irradiation of Hodgkin's disease stages III and IV. Cancer 1978;42:437-441.Crossref 2. Maxon HR, Thomas SR, Swenger EL, et al: Ionizing irradiation and the induction of clinically significant disease in the human thyroid gland. Am J Med 1977;63:967-978.Crossref 3. Rubin P, Caserett GW: Clinical Radiation Pathology . Philadelphia, WB Saunders Co, 1968, p 752. 4. Fachnie JD, Rao SI: Painless thyroiditis with hyperthyroidism following external irradiation to the neck. Henry Ford Hosp Med J 1980;28: 149-151. 5. Constine LS, Donaldson SS, McDougal IR, et al: Thyroid dysfunction after radiotherapy in children with Hodgkin's disease. Cancer 1984;28:878-883.Crossref 6. Smith RE, Adler RA, Clark P, et al: Thyroid function after mantle irradiation in Hodgkin's disease. JAMA 1981;245:46-49.Crossref 7. DeJongJMA, Van Daal WAJ, Elte JWF, et al: Primary hypothyroidism as a complication after treatment of tumours of the head and neck. Acta Radiol Oncol 1982;21:299-303.Crossref 8. Kim YH, Fayos JV, Sisson JC: Thyroid function following neck irradiation for malignant lymphoma. Radiology 1980;134:205-208.Crossref 9. Shalet SM, Rosenstock JD, Beardwell CG, et al: Thyroid dysfunction following external irradiation to the neck of Hodgkin's disease in childhood. Clin Radiol 1977;28:511-515.Crossref 10. Nelson DF, Reddy KV, O'Mara RE, et al: Thyroid abnormalities following neck irradiation for Hodgkin's disease. Cancer 1978;42:2553-2562.Crossref 11. Glatstein E, McHardy-Young S, Brast N, et al: Alterations in serum thyrotropin (TSH) and thyroid function following radiotherapy in patients with malignant lymphoma. J Clin Endocrinol Metabol 1971;32:833-841.Crossref 12. Schimpff SE, Diggs CH, Wiswell CH, et al: Radiation-related thyroid dysfunction: Implications for the treatment of Hodgkin's disease. Ann Intern Med 1980;92:91-98.Crossref 13. Wasnich RD, Grumet FC, Payne RO, et al: Graves' ophthalmopathy following external neck irradiation for nonthyroidal neoplastic disease. J Clin Endocrinol Metabol 1973;37:703-713.Crossref 14. Braverman LE, in Werner SC, Ingbar SH: The Thyroid , ed 4. Hagerstown, Md, Harper & Row Publishers Inc, 1978, p 528. 15. Williams RH (ed): Textbook of Endocrinology . Philadelphia, WB Saunders Co, 1981. 16. Levine SN: Current concepts of thyroiditis. Arch Intern Med 1983;43: 1952-1956.Crossref 17. Isselbacher KJ, Adams RD, Braunwald E, et al (eds): Harrison's Principles of Internal Medicine . New York, McGraw-Hill Book Co, 1980, pp 1704-1708.
Archives of Internal Medicine – American Medical Association
Published: Sep 1, 1985
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