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Thyroid Hormone Use and Bone Mineral Density

Thyroid Hormone Use and Bone Mineral Density To the Editor. —Dr Schneider and colleagues1 provide important new data on the long-term effect of thyroid hormone use on bone. Use of "suppressive" dose thyroid hormone was associated with significantly decreased bone mineral density (BMD) measured at multiple skeletal sites in the nearly 1000 women studied in a retirement community. Overall, for the 20% who were thyroid hormone users, multivariate-adjusted BMD was significantly lower at the midshaft radius, total hip, and lumbar spine sites, but the mean differences from nonusers were small in absolute number and amounted to 3.8%, 3.3%, and 3.2%, respectively (data from Schneider et al,1 Table 2). Schneider et al present evidence that thyroid hormone use is itself associated with osteopenia and not just the occurrence of prior endogenous hyperthyroidism. Yet controversy remains regarding the risk of bone loss from prescription thyroid hormone excess whether intentional as suppressive therapy or inadvertent. Furthermore, from other http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Thyroid Hormone Use and Bone Mineral Density

Krakauer, Jesse C.
JAMA , Volume 272 (23) – Dec 21, 1994
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Thyroid Hormone Use and Bone Mineral Density

Abstract



To the Editor.
—Dr Schneider and colleagues1 provide important new data on the long-term effect of thyroid hormone use on bone. Use of "suppressive" dose thyroid hormone was associated with significantly decreased bone mineral density (BMD) measured at multiple skeletal sites in the nearly 1000 women studied in a retirement community. Overall, for the 20% who were thyroid hormone users, multivariate-adjusted BMD was significantly lower at the midshaft radius, total hip, and...
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References (6)

Publisher
American Medical Association
Copyright
Copyright © 1994 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1994.03520230032029
Publisher site
See Article on Publisher Site

Abstract

To the Editor. —Dr Schneider and colleagues1 provide important new data on the long-term effect of thyroid hormone use on bone. Use of "suppressive" dose thyroid hormone was associated with significantly decreased bone mineral density (BMD) measured at multiple skeletal sites in the nearly 1000 women studied in a retirement community. Overall, for the 20% who were thyroid hormone users, multivariate-adjusted BMD was significantly lower at the midshaft radius, total hip, and lumbar spine sites, but the mean differences from nonusers were small in absolute number and amounted to 3.8%, 3.3%, and 3.2%, respectively (data from Schneider et al,1 Table 2). Schneider et al present evidence that thyroid hormone use is itself associated with osteopenia and not just the occurrence of prior endogenous hyperthyroidism. Yet controversy remains regarding the risk of bone loss from prescription thyroid hormone excess whether intentional as suppressive therapy or inadvertent. Furthermore, from other

Journal

JAMA – American Medical Association

Published: Dec 21, 1994

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