Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Thymostimulin in Treatment of Psoriasis

Thymostimulin in Treatment of Psoriasis Abstract To the Editor.— Thymostimulin (TMS), a calf thymus extract, can be successfully used in the treatment of patients with viral diseases and cell-mediated immune defects. A significant reduction in the number of total circulating T lymphocytes has been observed in patients with psoriasis, while the number of circulating B cells was normal and there was an increase of null cells.1 In skin, the dermal mononuclear infiltrate consists almost exclusively of T lymphocytes and macrophages.2Recently, Baker et al3 studied the relationship between T-cell populations in blood and in skin of psoriatic patients as well as the correlation with the chronicity, type, and extent of the skin lesions. In blood from patients with guttate psoriasis (GP), the reduction in the number of T lymphocytes was due entirely to a decrease in T helper-inducer (Th) cells. In chronic plaque (CP) psoriasis, both Th and suppressor-cytotoxic T-lymphocyte (Ts) subset were References 1. Glinski W, Obalek S, Langner A, et al: Defective function of T lymphocytes in psoriasis . J Invest Dermatol 1978;70:105-110.Crossref 2. Bjerke JE, Krogh HK, Matre R: Characterization of mononuclear cell infiltrate in psoriatic lesions . J Invest Dermatol 1978;71:340-343.Crossref 3. Baker BS, Swain AF, Valdimarsson H, et al: T-cell subpopulations in the blood and skin of patients with psoriasis . Br J Dermatol 1984;110:37-44.Crossref 4. Baker BS, Swain AF, Fry L, et al: Epidermal T lymphocytes and HLA-DR expression in psoriasis . Br J Dermatol 1984;110:555-564.Crossref 5. Staughton RCD, Byrom NA, Nagvekar NM, et al: Thymostimulin therapy of adult atopic eczema: A phase 1 clinical trial , in Byrom NA, Hobbs JR (eds): Thymic Factor Therapy . New York, Raven Press, 1984, pp 415-424. 6. Bos JD, Krieg SR: Psoriasis infiltrating cell immunopheno-type: Changes induced by PUVA or corticosteroid treatment in T-cell subsets, Langerhans' cells and interdigitating cells . Acta Derm Venereol 1985;65:390-397. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Thymostimulin in Treatment of Psoriasis

Archives of Dermatology , Volume 122 (6) – Jun 1, 1986

Thymostimulin in Treatment of Psoriasis

Abstract

Abstract To the Editor.— Thymostimulin (TMS), a calf thymus extract, can be successfully used in the treatment of patients with viral diseases and cell-mediated immune defects. A significant reduction in the number of total circulating T lymphocytes has been observed in patients with psoriasis, while the number of circulating B cells was normal and there was an increase of null cells.1 In skin, the dermal mononuclear infiltrate consists almost exclusively of T lymphocytes and...
Loading next page...
 
/lp/american-medical-association/thymostimulin-in-treatment-of-psoriasis-NOLIA3hvuY

References (6)

Publisher
American Medical Association
Copyright
Copyright © 1986 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1986.01660180024004
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor.— Thymostimulin (TMS), a calf thymus extract, can be successfully used in the treatment of patients with viral diseases and cell-mediated immune defects. A significant reduction in the number of total circulating T lymphocytes has been observed in patients with psoriasis, while the number of circulating B cells was normal and there was an increase of null cells.1 In skin, the dermal mononuclear infiltrate consists almost exclusively of T lymphocytes and macrophages.2Recently, Baker et al3 studied the relationship between T-cell populations in blood and in skin of psoriatic patients as well as the correlation with the chronicity, type, and extent of the skin lesions. In blood from patients with guttate psoriasis (GP), the reduction in the number of T lymphocytes was due entirely to a decrease in T helper-inducer (Th) cells. In chronic plaque (CP) psoriasis, both Th and suppressor-cytotoxic T-lymphocyte (Ts) subset were References 1. Glinski W, Obalek S, Langner A, et al: Defective function of T lymphocytes in psoriasis . J Invest Dermatol 1978;70:105-110.Crossref 2. Bjerke JE, Krogh HK, Matre R: Characterization of mononuclear cell infiltrate in psoriatic lesions . J Invest Dermatol 1978;71:340-343.Crossref 3. Baker BS, Swain AF, Valdimarsson H, et al: T-cell subpopulations in the blood and skin of patients with psoriasis . Br J Dermatol 1984;110:37-44.Crossref 4. Baker BS, Swain AF, Fry L, et al: Epidermal T lymphocytes and HLA-DR expression in psoriasis . Br J Dermatol 1984;110:555-564.Crossref 5. Staughton RCD, Byrom NA, Nagvekar NM, et al: Thymostimulin therapy of adult atopic eczema: A phase 1 clinical trial , in Byrom NA, Hobbs JR (eds): Thymic Factor Therapy . New York, Raven Press, 1984, pp 415-424. 6. Bos JD, Krieg SR: Psoriasis infiltrating cell immunopheno-type: Changes induced by PUVA or corticosteroid treatment in T-cell subsets, Langerhans' cells and interdigitating cells . Acta Derm Venereol 1985;65:390-397.

Journal

Archives of DermatologyAmerican Medical Association

Published: Jun 1, 1986

There are no references for this article.