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Thrush in Malignant Neoplastic Disease

Thrush in Malignant Neoplastic Disease Abstract Thrush is most frequently found in infants or debilitated patients with serious diseases such as a malignant neoplasm. Candida albicans is the causative organism in most cases, although C. tropicalis,1 C. pseudotropicalis,2 C. krusei,3 C. parapsilosis,4 and C. guilliermondi,5 have all been reported as pathogenic agents for man. The Candida are common saprophytes of the gastrointestinal tract and may assume a pathogenic role under certain circumstances. Candida infections may be increasing in frequency, and antibiotic and adrenal corticosteroid therapy have been implicated as a cause of this increase by many authors.6-8 Brown and Hazen's isolation of nystatin from Streptomyces noursei9 has given impetus to the study of Candida infections. This antibiotic is effective against Candida in vitro,10 and clinical reports are generally favorable. Little is known of the natural history of untreated thrush or of the efficacy of simple cleansing of the References 1. Duroux, A.; Jarniou, B.; Granetier, R., and Lemaire, P.: Mycose pulmonaire mortelle provoquée par les antibiotiques , Bull. et mém. Soc. méd. hôp. Paris 70:611-619, 1954. 2. Beuthe, D.: Candidasepsis , Zentralbl. allg. Path. 93:241-245, 1955. 3. Mirman, J. M.: Moniliasis of the Biliary Tract: Report of a Case , J. Lab. & Clin. Med. 19: 379-381, 1934. 4. Wikler, A.; Williams, E. G., and Wiesel, C.: Monilemia Associated with Toxic Purpura: Report of a Case , Arch. Neurol. & Psychiat. 50:661-668, 1943. 5. Zimmerman, L. E.: Candida and Aspergillus Endocarditis, with Comments on the Role of Antibiotics in Dissemination of Fungus Disease , Arch. Path. 50:591-605, 1950. 6. Winter, W. D., Jr., and Foley, G. E.: Candida Infections in Children with Neoplastic Disease: Influence of Therapy with Antibiotics and Steroid Hormones , Pediatrics 18:595-603, 1956. 7. Robinson, H. M., Jr.: Moniliasis Complicating Antibiotic Therapy , A.M.A. Arch. Dermat. & Syph. 70:648-652, 1954. 8. McGovern, J. J.; Parrott, R. H.; Emmons, C. W.; Ross, S.; Burke, F. G., and Rice, E. C.: Effect of Aureomycin and Chloramphenicol on the Fungal and Bacterial Flora of Children , New England J. Med. 248:397-403, 1953. 9. Brown, R., and Hazen, E. L.; Investigations on Antagonistic Microorganisms and Antibiotic Agents: Antifungal Substance from Actinomyces , Annual Report, New York State Department of Health, Division Laboratory Research, 1949, pp. 19-21. 10. Eisenberg, G. M.; Weiss, W., and Flippin, H. F.: Microbiologic Studies and Preliminary Clinical Experiences with Nystatin: I. In Vitro Susceptibility of Candida Albicans, Antibiotics Ann. pp. 837-845, 1955-1956. 11. Faber, H. K., and Dickey, L. B.: The Treatment of Thrush with Gentian Violet , J.A.M.A. 85: 900-901, 1925. 12. Kazinn, P. J.; Taschdjean, C. L.; Dragutsky, D., and Minsky, A.: Therapy of Oral Thrush: A Comparative Evaluation of Gentian Violet, Mycostatin and Amphotericin B , Monogr. Therap. 2:16-24, 1957. 13. Wright, E. T.; Graham, J. H., and Sternberg, T. H.: Treatment of Moniliasis with Nystatin , J.A.M.A. 163:92-94, 1957. 14. Huang, N. H.; Kendall, N.; Lamberti, A. J., and High, R. H.: Effect of Nystatin on Oral Moniliasis in Infants, Antibiotics Ann., pp. 711-718, 1955-1956. 15. Stewart, G. T.: Laboratory and Clinical Studies with Nystatin in Post-Antibiotic Mycotic Infections , Brit. M.J. 1:658-660, 1956. 16. Metzger, W. I.; Steigmann, F.; Jenkins, C. J., Jr.; Pamukcu, S. F., and Kaminski, L.: Comparative Effects of Tetracycline Alone and in Combination with Nystatin on the Intestinal Flora of Man, Antibiotics Ann., pp. 208-215, 1956-1957. 17. Lepper, M. H., and Pearson, J. Z.: A Study of the Effect of Tetracycline Plus Nystatin on Aerobic Fecal Flora as Compared to Tetracycline Alone, Antibiotics Ann., pp. 221-227, 1956-1957. 18. Hewitt, W. L.; Finegold, S. M., and Sutter, V. L.: Incidence of Side Effects and Changes in Fecal Microflora Following Administration of Tetracycline and Tetracycline-Nystatin, Antibiotics Ann., pp. 856-861, 1955-1956. 19. Martin, D. S.; Jones, C. P.; Yao, K. F., and Lee, L. E., Jr.: A Practical Classification of the Monilias , J. Bact. 34:99-105, 1937. 20. Festinger, L.: The Significance of Difference Between Means Without Reference to Frequency Distribution Function , Psychometrica 11:2, 103, 1946. 21. Reyes, A. C., and Reyes, A.: Studies on Candida Albicans Infection in Filipino Children: I. Occurrence of C. Albicans in the Normal Mouth , Acta med. philip. 13:147-150, 1957. 22. Reyes, A., and Reyes, A. C.: Studies on Candida Albicans Infection in Filipino Children: II. Prevalence of Oral Moniliasis , Acta med. philip. 13:151-155, 1957. 23. Woods, J. W.; Manning, I. H., Jr., and Patterson, C. N.: Monilial Infections Complicating the Therapeutic Use of Antibiotics , J.A.M.A. 145: 207-211, 1951. 24. Seligmann, E.: Virulence Enhancement of Candida Albicans by Antibiotics and Cortisone , Proc. Soc. Exper. Biol. & Med. 83:778-781, 1953. 25. Robinson, H. M., Jr.: Moniliasis Complicating Antibiotic Therapy: Clinical and Laboratory Studies , A.M.A. Arch. Dermat. & Syph. 70:640-652, 1954. 26. Montana, J. A., and Sery, T. W.: Effect of Fungistatic Agents on Corneal Infections with Candida Albicans , A.M.A. Arch. Ophth. 60:1-6, 1958. 27. Spaulding, E. H., and Tyson, R. R.: The Role of Nystatin in Intestinal Antisepsis , Monogr. on Therap. 2:38-42, 1957. 28. Boggs, D. R., and Frei, E., III: Clinical Studies of Fever and Infection in Malignant Neoplastic Disease , Cancer , to be published. 29. Bratlund, H., and Holten, C.: Moniliasis of Mucous Membranes and Lungs as a Complication of Treatment with Antibiotics, Corticotropin and Cortisone , Danish M. Bull. 1:79-84, 1954. 30. Matthias, J. Q., and Rees, E. G.: Candida Septicaemia Complicating Antibiotic Therapy , J. Path. & Bact. 71:512-516, 1956. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

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Publisher
American Medical Association
Copyright
Copyright © 1961 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1961.03620030042005
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Abstract

Abstract Thrush is most frequently found in infants or debilitated patients with serious diseases such as a malignant neoplasm. Candida albicans is the causative organism in most cases, although C. tropicalis,1 C. pseudotropicalis,2 C. krusei,3 C. parapsilosis,4 and C. guilliermondi,5 have all been reported as pathogenic agents for man. The Candida are common saprophytes of the gastrointestinal tract and may assume a pathogenic role under certain circumstances. Candida infections may be increasing in frequency, and antibiotic and adrenal corticosteroid therapy have been implicated as a cause of this increase by many authors.6-8 Brown and Hazen's isolation of nystatin from Streptomyces noursei9 has given impetus to the study of Candida infections. This antibiotic is effective against Candida in vitro,10 and clinical reports are generally favorable. Little is known of the natural history of untreated thrush or of the efficacy of simple cleansing of the References 1. Duroux, A.; Jarniou, B.; Granetier, R., and Lemaire, P.: Mycose pulmonaire mortelle provoquée par les antibiotiques , Bull. et mém. Soc. méd. hôp. Paris 70:611-619, 1954. 2. Beuthe, D.: Candidasepsis , Zentralbl. allg. Path. 93:241-245, 1955. 3. Mirman, J. M.: Moniliasis of the Biliary Tract: Report of a Case , J. Lab. & Clin. Med. 19: 379-381, 1934. 4. Wikler, A.; Williams, E. G., and Wiesel, C.: Monilemia Associated with Toxic Purpura: Report of a Case , Arch. Neurol. & Psychiat. 50:661-668, 1943. 5. Zimmerman, L. E.: Candida and Aspergillus Endocarditis, with Comments on the Role of Antibiotics in Dissemination of Fungus Disease , Arch. Path. 50:591-605, 1950. 6. Winter, W. D., Jr., and Foley, G. E.: Candida Infections in Children with Neoplastic Disease: Influence of Therapy with Antibiotics and Steroid Hormones , Pediatrics 18:595-603, 1956. 7. Robinson, H. M., Jr.: Moniliasis Complicating Antibiotic Therapy , A.M.A. Arch. Dermat. & Syph. 70:648-652, 1954. 8. McGovern, J. J.; Parrott, R. H.; Emmons, C. W.; Ross, S.; Burke, F. G., and Rice, E. C.: Effect of Aureomycin and Chloramphenicol on the Fungal and Bacterial Flora of Children , New England J. Med. 248:397-403, 1953. 9. Brown, R., and Hazen, E. L.; Investigations on Antagonistic Microorganisms and Antibiotic Agents: Antifungal Substance from Actinomyces , Annual Report, New York State Department of Health, Division Laboratory Research, 1949, pp. 19-21. 10. Eisenberg, G. M.; Weiss, W., and Flippin, H. F.: Microbiologic Studies and Preliminary Clinical Experiences with Nystatin: I. In Vitro Susceptibility of Candida Albicans, Antibiotics Ann. pp. 837-845, 1955-1956. 11. Faber, H. K., and Dickey, L. B.: The Treatment of Thrush with Gentian Violet , J.A.M.A. 85: 900-901, 1925. 12. Kazinn, P. J.; Taschdjean, C. L.; Dragutsky, D., and Minsky, A.: Therapy of Oral Thrush: A Comparative Evaluation of Gentian Violet, Mycostatin and Amphotericin B , Monogr. Therap. 2:16-24, 1957. 13. Wright, E. T.; Graham, J. H., and Sternberg, T. H.: Treatment of Moniliasis with Nystatin , J.A.M.A. 163:92-94, 1957. 14. Huang, N. H.; Kendall, N.; Lamberti, A. J., and High, R. H.: Effect of Nystatin on Oral Moniliasis in Infants, Antibiotics Ann., pp. 711-718, 1955-1956. 15. Stewart, G. T.: Laboratory and Clinical Studies with Nystatin in Post-Antibiotic Mycotic Infections , Brit. M.J. 1:658-660, 1956. 16. Metzger, W. I.; Steigmann, F.; Jenkins, C. J., Jr.; Pamukcu, S. F., and Kaminski, L.: Comparative Effects of Tetracycline Alone and in Combination with Nystatin on the Intestinal Flora of Man, Antibiotics Ann., pp. 208-215, 1956-1957. 17. Lepper, M. H., and Pearson, J. Z.: A Study of the Effect of Tetracycline Plus Nystatin on Aerobic Fecal Flora as Compared to Tetracycline Alone, Antibiotics Ann., pp. 221-227, 1956-1957. 18. Hewitt, W. L.; Finegold, S. M., and Sutter, V. L.: Incidence of Side Effects and Changes in Fecal Microflora Following Administration of Tetracycline and Tetracycline-Nystatin, Antibiotics Ann., pp. 856-861, 1955-1956. 19. Martin, D. S.; Jones, C. P.; Yao, K. F., and Lee, L. E., Jr.: A Practical Classification of the Monilias , J. Bact. 34:99-105, 1937. 20. Festinger, L.: The Significance of Difference Between Means Without Reference to Frequency Distribution Function , Psychometrica 11:2, 103, 1946. 21. Reyes, A. C., and Reyes, A.: Studies on Candida Albicans Infection in Filipino Children: I. Occurrence of C. Albicans in the Normal Mouth , Acta med. philip. 13:147-150, 1957. 22. Reyes, A., and Reyes, A. C.: Studies on Candida Albicans Infection in Filipino Children: II. Prevalence of Oral Moniliasis , Acta med. philip. 13:151-155, 1957. 23. Woods, J. W.; Manning, I. H., Jr., and Patterson, C. N.: Monilial Infections Complicating the Therapeutic Use of Antibiotics , J.A.M.A. 145: 207-211, 1951. 24. Seligmann, E.: Virulence Enhancement of Candida Albicans by Antibiotics and Cortisone , Proc. Soc. Exper. Biol. & Med. 83:778-781, 1953. 25. Robinson, H. M., Jr.: Moniliasis Complicating Antibiotic Therapy: Clinical and Laboratory Studies , A.M.A. Arch. Dermat. & Syph. 70:640-652, 1954. 26. Montana, J. A., and Sery, T. W.: Effect of Fungistatic Agents on Corneal Infections with Candida Albicans , A.M.A. Arch. Ophth. 60:1-6, 1958. 27. Spaulding, E. H., and Tyson, R. R.: The Role of Nystatin in Intestinal Antisepsis , Monogr. on Therap. 2:38-42, 1957. 28. Boggs, D. R., and Frei, E., III: Clinical Studies of Fever and Infection in Malignant Neoplastic Disease , Cancer , to be published. 29. Bratlund, H., and Holten, C.: Moniliasis of Mucous Membranes and Lungs as a Complication of Treatment with Antibiotics, Corticotropin and Cortisone , Danish M. Bull. 1:79-84, 1954. 30. Matthias, J. Q., and Rees, E. G.: Candida Septicaemia Complicating Antibiotic Therapy , J. Path. & Bact. 71:512-516, 1956.

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Mar 1, 1961

References