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Through a Glass, Darkly

Through a Glass, Darkly EDITORIAL Cerebrospinal Fluid Viral Load Measurements and the Pathogenesis of Human Immunodeficiency Virus Infection of the Central Nervous System HE NEUROLOGICAL manifestations of hu- autopsy evidence of HIV encephalitis. The annual in- man immunodeficiency virus (HIV) in- cidence of HIV dementia was approximately 7% in pa- fection are a major source of morbidity and tients with AIDS but has dropped by 50% since the in- mortality despite advances in antiretrovi- troduction of highly active antiretroviral therapy. T ral therapy. Viral invasion of the central In this issue of the ARCHIVES, Ellis et al describe a nervous system (CNS) occurs as an extremely early event prospective study that looked at the utility of CSF HIV 1,2 following HIV infection, yet, generally, productive in- RNA levels as a predictor of future progression to neu- fection is uncommon until later in HIV/acquired immu- ropsychological impairment in HIV-infected individu- nodeficiency syndrome (AIDS), after the development of als. This study represents a logical progression from prior immunosuppression. In approximately 10% of pa- work indicating that CSF HIV-1 RNA levels were el- tients, initial (acute) HIV infection is associated with acute evated in cognitively impaired subjects compared with 20,23-25 self-limited meningitis or encephalitis, although it http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Neurology American Medical Association

Through a Glass, Darkly

Tyler, Kenneth L.; McArthur, Justin C.
JAMA Neurology , Volume 59 (6) – Jun 1, 2002
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Publisher
American Medical Association
Copyright
Copyright 2002 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6149
eISSN
2168-6157
DOI
10.1001/archneur.59.6.909
Publisher site
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Abstract

EDITORIAL Cerebrospinal Fluid Viral Load Measurements and the Pathogenesis of Human Immunodeficiency Virus Infection of the Central Nervous System HE NEUROLOGICAL manifestations of hu- autopsy evidence of HIV encephalitis. The annual in- man immunodeficiency virus (HIV) in- cidence of HIV dementia was approximately 7% in pa- fection are a major source of morbidity and tients with AIDS but has dropped by 50% since the in- mortality despite advances in antiretrovi- troduction of highly active antiretroviral therapy. T ral therapy. Viral invasion of the central In this issue of the ARCHIVES, Ellis et al describe a nervous system (CNS) occurs as an extremely early event prospective study that looked at the utility of CSF HIV 1,2 following HIV infection, yet, generally, productive in- RNA levels as a predictor of future progression to neu- fection is uncommon until later in HIV/acquired immu- ropsychological impairment in HIV-infected individu- nodeficiency syndrome (AIDS), after the development of als. This study represents a logical progression from prior immunosuppression. In approximately 10% of pa- work indicating that CSF HIV-1 RNA levels were el- tients, initial (acute) HIV infection is associated with acute evated in cognitively impaired subjects compared with 20,23-25 self-limited meningitis or encephalitis, although it

Journal

JAMA Neurology – American Medical Association

Published: Jun 1, 2002

References

  • Early penetration of the blood-brain barrier by HIV.
    Resnick, L; Berger, JR; Shapshak, P; Tourtellotte, WW