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Thrombophlebitis, Blood Coagulation, and Pancreatic Disease: A Study of the Pancreatic Secretion in Patients with Thrombophlebitis

Thrombophlebitis, Blood Coagulation, and Pancreatic Disease: A Study of the Pancreatic Secretion... Abstract The association of pancreatic cancer and recurring thrombophlebitis was first recorded by Trousseau.1 In 1934, Sproul,2 from a careful and extensive study of postmortem material, stressed the unusually high frequency of thrombophlebitis in malignant diseases of the body and tail of the pancreas. This finding has been corroborated by the investigations of Kenny3 and others,* but the pathogenesis of the relationship has remained obscure. The most commonly suggested etiological mechanism has related the thrombophlebitis to alterations in blood coagulation. Changes in the blood coagulation mechanism have been noted by many observers, usually in connection with studies of experimental and clinical pancreatitis.† Blood coagulation alterations have also been recorded in patients with pancreatic cancer and have been stressed recently by Shingleton8 and Innerfield,9 who introduced laboratory diagnostic procedures based upon them. Shingleton, using his paritol blood coagulation test technique, noted that an increased blood clotting reaction References 1. References 4 and 5. 2. References 6 and 7. 3. References 2 and 4. 4. References 44-47. 5. References 12 and 13. 6. References 5 and 14. 7. References 3, 4, and 15. 8. References 2 and 4. 9. References 6 and 7. 10. References 17-20. 11. References 16 and 21-23. 12. References 24 and 28. 13. References 8 and 32-34. 14. References 6, 8, 9, 16, and 30. 15. References 32, 34, and 35. 16. References 33 and 41-43. 17. Trousseau, A.: Clinique médicale de l'Hotel-Dieu de Paris , Ed. 3, Paris, Barrière, 1877, pp. 80 and 739. 18. Sproul, E. E.: Cancer and Venous Thrombosis: Frequency of Association of Carcinoma in the Body and Tail of the Pancreas with Multiple Venous Thrombosis , Am. J. Cancer 34:566, 1938. 19. Kenney, W. E.: The Association of Carcinoma in the Tail and Body of the Pancreas with Multiple Venous Thrombosis , Surgery 14:600, 1943. 20. Jennings, W. K., and Russell, W. O.: Phlebothrombosis Associated with Mucin Producing Carcinoma of the Tail and Body of the Pancreas , Arch. Surg. 56:186, 1948.Crossref 21. Thompson, C. M., and Rodgers, L. R.: Analysis of Autopsy Records of 157 Cases of Cancer of the Pancreas with Particular Reference to the Incidence of Thromboembolism , Am. J. M. Sc. 223:469, 1952.Crossref 22. Rich, A. R., and Duff, G. L.: Experimental and Pathologic Studies on the Pathogenesis of Acute Hemorrhagic Pancreatitis , Bull. Johns Hopkins Hosp. 58:212, 1936. 23. Lasher, E. P., and McCabe, M. M.: Changes in Coagulation Time Associated with Experimental Acute Pancreatitis in Dogs , Arch. Surg. 60:164, 1950.Crossref 24. Shingleton, W. W.; Anlyan, W. G., and Hart, D.: The Diagnosis of Pancreatic Disorders by Certain Laboratory Procedures , Ann. Surg. 136: 578, 1952. 25. Innerfield, I.; Angrist, A., and Benjamin, J. W.: Plasma Antithrombin Patterns in Disturbances of the Pancreas , Gastroenterology 19: 843, 1951. 26. Dreiling, D. A., and Hollander, F.: Studies in Pancreatic Function: II. A Statistical Study of Pancreatic Secretion Following Secretin in Patients Without Pancreatic Disease , Gastroenterology 15:620, 1950. 27. Dreiling, D. A.: Studies in Pancreatic Function: V. The Use of the Secretin Test in the Diagnosis of Pancreatitis and in the Demonstration of Pancreatic Insufficiencies in Gastrointestinal Disorders , Gastroenterology 24:540, 1953. 28. Lawrence, E. A.; Bowman, D.; Moore, D. B., and Bernstein, G. I.: A Thromboplastic Property of Neoplasms , S. Forum (1952) , p. 694, 1953. 29. Hubay, C. A., and Holden, W. D.: Venous Thrombosis, Necrosis, and Neoplasia , Surg. Gynec. & Obst. 98:309, 1954. 30. Moulton, S. E.; Vroman, L.; Vroman, G. M. S., and Goodman, B.: Role of Blood Platelets in Thromboembolism , Arch. Int. Med. 84:667, 1949. 31. Edwards, E. A.: Migratory Thrombophlebitis Associated with Cancer , New England J. Med. 240:1031, 1949. 32. Storer, J., and Kazdan, P.: The Relationship of the Pancreas to Blood Coagulation , Surgery 33:683, 1953. 33. Figurelli, G.: Tempo di sanguinamento e tempo di coagulazione nei malati di cancra , Morgagni 73:2429, 1931. 34. Bock, H., and Rausche, C.: Über die Bedeutung der Blutgerinnungsvalenz für die Krebsdiagnose , Zentrabl. Chir. 53:1440, 1926. 35. Abramson, B. P.: The Importance of Blood Coagulation in the Diagnosis of Cancer , Vestnik khir. 17:39, 1929. 36. Mendeleéf, P.: Nouvelle Méthode de diagnostic du cancer par le pouvoir coagulant des elements figurés du sang , Compt. rend. Soc. biol. 119:1190, 1935. 37. Hecht, E.: Blood Clotting and the Pancreas , Acta med. scandinav. 129:311, 1947. 38. Bechgaard, P.: Acute Pancreatitis , Ugesk. læger 103:1523, 1941. 39. Borgstrom, S.: Chronic Pancreatitis , Acta chir. scandinav. 90:419, 1944. 40. Ferrari, R., and Cortese, F.: Influenza del pancreas sulla coagulazione de sangue , Arch. fisiol. 31:274, 1932. 41. Boldyreff, W. N., and Boldyreff, A. W.: Le Pankreas, source de fibrine ferment du sang , Compt. rend. Soc. Biol. 95:477, 1926. 42. Turcatti, E. S.: Role du pancreas sur le coagulation du sang , Compt. rend. Soc. Biol. 100: 116, 1929. 43. Lundberg, E.: Influence of Pancreatic Extracts on Coagulation Time of Blood , Svenska läk.-tidning. 28:1081, 1931. 44. Hiruma, K.: Studien über di Beziehung einzelner Organe zur Blutgerinnung und über die Beeinflussung der Thrombinwirkung durch Sekrete und Exkrete nebst Untersuchungen über Antithrombin und über Fibrinolyse , Biochem. Ztschr. 139:152, 1923. 45. Shinowara, G. Y.; Waite, J. H., and Saleeby, R. G.: Plasma Coagulation Factors in Acute Pancreatitis , Proc. Soc. Exper. Biol. & Med. 83:423, 1953. 46. Rush, B., and Clifton, E. E.: The Role of Trypsin in the Pathogenesis of Acute Hemorrhagic Pancreatitis and the Effect of an Antitryptic Agent in Treatment , Surgery 31:1, 1952. 47. Coffey, R. J.; Brinig, F. J., and Gillespie, J.: Trypsin and Antitrypsin in Acute Pancreatic Disease , in S. Forum (1950) , p. 166, 1951. 48. Eagle, H., and Harris, T.: Studies in Blood Coagulation: I. The Coagulation of Blood by Proteolytic Enzymes , J. Gen. Physiol. 20:543, 1937. 49. Ferguson, J. H., and Erickson, B. N.: The Coagulation Action of Crystalline Trypsin , Proc. Roy. Soc. London 125:204, 1938. 50. Tagnon, H. J.: The Nature of the Mechanism of Shock Produced by the Injection of Trypsin , J. Clin. Invest. 24:1, 1945. 51. Taylor, A.; Overman, R. S., and Wright, I. S.: Studies with Crystalline Trypsin , J. A. M. A. 155:347, 1954. 52. Innerfield, I.; Schwartz, A. W., and Angrist, A. A.: Fibrinolytic and Anticoagulant Effects of Intravenous Crystalline Trypsin , Bull. New York Acad. Med. 28:537, 1952. 53. Innerfield, I.; Angrist, A., and Schwartz, A.: Parenteral Administration of Trypsin , J. A. M. A. 152:597, 1953. 54. Innerfield, I.; Angrist, A., and Benjamin, J. W.: Antithrombin Titre in Acute Pancreatitis , Am. J. Med. 12:24, 1952. 55. Innerfield, I., and Angrist, A.: The Plasma Antithrombin Determination: A New Test for Cancer of the Pancreas Associated with Jaundice , Am. J. M. Sc. 223:422, 1952. 56. Innerfield, I.; Angrist, A., and Benjamin, J. W.: The Antithrombin Titre in Cystic Fibrosis of the Pancreas , J. Pediat. 39:287, 1951. 57. Roach, D. H., and Laufman, H.: The Use of Intravenous Trypsin in Experimental Pulmonary Embolism , Surgery 35:45, 1954. 58. Ormand, L. H., and Knight, V.: Evaluation of Anticoagulant Therapy , Am. J. Med. 14:720, 1953. 59. Peck, M. E.: Preliminary Observations on the Effect of Trypsin Administered Intravenously , J. A. M. A. 154:1260, 1954. 60. Osborne, R.: Functioning Acinous Cell Carcinoma of the Pancreas Accompanied with Widespread Fat Necrosis , Arch. Int. Med. 85:933, 1950.Crossref 61. Perry, T. T.: Role of Lymphatic Vessels in Transmission of Lipase in Disseminated Fat Necrosis , Arch. Path. 43:456, 1947. 62. Konematsu, S.; Pack, G., and Stewart, F. W.: A Study of Enzyme Content of a Parenchymatous Adenocarcinoma of the Pancreas and a Comparison with Normal Human Pancreas , Am. J. Cancer 26: 351, 1936.Crossref 63. Belsky, H., and Cornell, N. W.: Disseminated Fat Necrosis Following Radical Pancreatico-Duodenectomy for Acinous Cancer of the Head of the Pancreas , Ann. Surg. 141:556, 1955.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Internal Medicine American Medical Association

Thrombophlebitis, Blood Coagulation, and Pancreatic Disease: A Study of the Pancreatic Secretion in Patients with Thrombophlebitis

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References (60)

Publisher
American Medical Association
Copyright
Copyright © 1955 American Medical Association. All Rights Reserved.
ISSN
0888-2479
DOI
10.1001/archinte.1955.00250150064006
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Abstract

Abstract The association of pancreatic cancer and recurring thrombophlebitis was first recorded by Trousseau.1 In 1934, Sproul,2 from a careful and extensive study of postmortem material, stressed the unusually high frequency of thrombophlebitis in malignant diseases of the body and tail of the pancreas. This finding has been corroborated by the investigations of Kenny3 and others,* but the pathogenesis of the relationship has remained obscure. The most commonly suggested etiological mechanism has related the thrombophlebitis to alterations in blood coagulation. Changes in the blood coagulation mechanism have been noted by many observers, usually in connection with studies of experimental and clinical pancreatitis.† Blood coagulation alterations have also been recorded in patients with pancreatic cancer and have been stressed recently by Shingleton8 and Innerfield,9 who introduced laboratory diagnostic procedures based upon them. Shingleton, using his paritol blood coagulation test technique, noted that an increased blood clotting reaction References 1. References 4 and 5. 2. References 6 and 7. 3. References 2 and 4. 4. References 44-47. 5. References 12 and 13. 6. References 5 and 14. 7. References 3, 4, and 15. 8. References 2 and 4. 9. References 6 and 7. 10. References 17-20. 11. References 16 and 21-23. 12. References 24 and 28. 13. References 8 and 32-34. 14. References 6, 8, 9, 16, and 30. 15. References 32, 34, and 35. 16. References 33 and 41-43. 17. Trousseau, A.: Clinique médicale de l'Hotel-Dieu de Paris , Ed. 3, Paris, Barrière, 1877, pp. 80 and 739. 18. Sproul, E. E.: Cancer and Venous Thrombosis: Frequency of Association of Carcinoma in the Body and Tail of the Pancreas with Multiple Venous Thrombosis , Am. J. Cancer 34:566, 1938. 19. Kenney, W. E.: The Association of Carcinoma in the Tail and Body of the Pancreas with Multiple Venous Thrombosis , Surgery 14:600, 1943. 20. Jennings, W. K., and Russell, W. O.: Phlebothrombosis Associated with Mucin Producing Carcinoma of the Tail and Body of the Pancreas , Arch. Surg. 56:186, 1948.Crossref 21. Thompson, C. M., and Rodgers, L. R.: Analysis of Autopsy Records of 157 Cases of Cancer of the Pancreas with Particular Reference to the Incidence of Thromboembolism , Am. J. M. Sc. 223:469, 1952.Crossref 22. Rich, A. R., and Duff, G. L.: Experimental and Pathologic Studies on the Pathogenesis of Acute Hemorrhagic Pancreatitis , Bull. Johns Hopkins Hosp. 58:212, 1936. 23. Lasher, E. P., and McCabe, M. M.: Changes in Coagulation Time Associated with Experimental Acute Pancreatitis in Dogs , Arch. Surg. 60:164, 1950.Crossref 24. Shingleton, W. W.; Anlyan, W. G., and Hart, D.: The Diagnosis of Pancreatic Disorders by Certain Laboratory Procedures , Ann. Surg. 136: 578, 1952. 25. Innerfield, I.; Angrist, A., and Benjamin, J. W.: Plasma Antithrombin Patterns in Disturbances of the Pancreas , Gastroenterology 19: 843, 1951. 26. Dreiling, D. A., and Hollander, F.: Studies in Pancreatic Function: II. A Statistical Study of Pancreatic Secretion Following Secretin in Patients Without Pancreatic Disease , Gastroenterology 15:620, 1950. 27. Dreiling, D. A.: Studies in Pancreatic Function: V. The Use of the Secretin Test in the Diagnosis of Pancreatitis and in the Demonstration of Pancreatic Insufficiencies in Gastrointestinal Disorders , Gastroenterology 24:540, 1953. 28. Lawrence, E. A.; Bowman, D.; Moore, D. B., and Bernstein, G. I.: A Thromboplastic Property of Neoplasms , S. Forum (1952) , p. 694, 1953. 29. Hubay, C. A., and Holden, W. D.: Venous Thrombosis, Necrosis, and Neoplasia , Surg. Gynec. & Obst. 98:309, 1954. 30. Moulton, S. E.; Vroman, L.; Vroman, G. M. S., and Goodman, B.: Role of Blood Platelets in Thromboembolism , Arch. Int. Med. 84:667, 1949. 31. Edwards, E. A.: Migratory Thrombophlebitis Associated with Cancer , New England J. Med. 240:1031, 1949. 32. Storer, J., and Kazdan, P.: The Relationship of the Pancreas to Blood Coagulation , Surgery 33:683, 1953. 33. Figurelli, G.: Tempo di sanguinamento e tempo di coagulazione nei malati di cancra , Morgagni 73:2429, 1931. 34. Bock, H., and Rausche, C.: Über die Bedeutung der Blutgerinnungsvalenz für die Krebsdiagnose , Zentrabl. Chir. 53:1440, 1926. 35. Abramson, B. P.: The Importance of Blood Coagulation in the Diagnosis of Cancer , Vestnik khir. 17:39, 1929. 36. Mendeleéf, P.: Nouvelle Méthode de diagnostic du cancer par le pouvoir coagulant des elements figurés du sang , Compt. rend. Soc. biol. 119:1190, 1935. 37. Hecht, E.: Blood Clotting and the Pancreas , Acta med. scandinav. 129:311, 1947. 38. Bechgaard, P.: Acute Pancreatitis , Ugesk. læger 103:1523, 1941. 39. Borgstrom, S.: Chronic Pancreatitis , Acta chir. scandinav. 90:419, 1944. 40. Ferrari, R., and Cortese, F.: Influenza del pancreas sulla coagulazione de sangue , Arch. fisiol. 31:274, 1932. 41. Boldyreff, W. N., and Boldyreff, A. W.: Le Pankreas, source de fibrine ferment du sang , Compt. rend. Soc. Biol. 95:477, 1926. 42. Turcatti, E. S.: Role du pancreas sur le coagulation du sang , Compt. rend. Soc. Biol. 100: 116, 1929. 43. Lundberg, E.: Influence of Pancreatic Extracts on Coagulation Time of Blood , Svenska läk.-tidning. 28:1081, 1931. 44. Hiruma, K.: Studien über di Beziehung einzelner Organe zur Blutgerinnung und über die Beeinflussung der Thrombinwirkung durch Sekrete und Exkrete nebst Untersuchungen über Antithrombin und über Fibrinolyse , Biochem. Ztschr. 139:152, 1923. 45. Shinowara, G. Y.; Waite, J. H., and Saleeby, R. G.: Plasma Coagulation Factors in Acute Pancreatitis , Proc. Soc. Exper. Biol. & Med. 83:423, 1953. 46. Rush, B., and Clifton, E. E.: The Role of Trypsin in the Pathogenesis of Acute Hemorrhagic Pancreatitis and the Effect of an Antitryptic Agent in Treatment , Surgery 31:1, 1952. 47. Coffey, R. J.; Brinig, F. J., and Gillespie, J.: Trypsin and Antitrypsin in Acute Pancreatic Disease , in S. Forum (1950) , p. 166, 1951. 48. Eagle, H., and Harris, T.: Studies in Blood Coagulation: I. The Coagulation of Blood by Proteolytic Enzymes , J. Gen. Physiol. 20:543, 1937. 49. Ferguson, J. H., and Erickson, B. N.: The Coagulation Action of Crystalline Trypsin , Proc. Roy. Soc. London 125:204, 1938. 50. Tagnon, H. J.: The Nature of the Mechanism of Shock Produced by the Injection of Trypsin , J. Clin. Invest. 24:1, 1945. 51. Taylor, A.; Overman, R. S., and Wright, I. S.: Studies with Crystalline Trypsin , J. A. M. A. 155:347, 1954. 52. Innerfield, I.; Schwartz, A. W., and Angrist, A. A.: Fibrinolytic and Anticoagulant Effects of Intravenous Crystalline Trypsin , Bull. New York Acad. Med. 28:537, 1952. 53. Innerfield, I.; Angrist, A., and Schwartz, A.: Parenteral Administration of Trypsin , J. A. M. A. 152:597, 1953. 54. Innerfield, I.; Angrist, A., and Benjamin, J. W.: Antithrombin Titre in Acute Pancreatitis , Am. J. Med. 12:24, 1952. 55. Innerfield, I., and Angrist, A.: The Plasma Antithrombin Determination: A New Test for Cancer of the Pancreas Associated with Jaundice , Am. J. M. Sc. 223:422, 1952. 56. Innerfield, I.; Angrist, A., and Benjamin, J. W.: The Antithrombin Titre in Cystic Fibrosis of the Pancreas , J. Pediat. 39:287, 1951. 57. Roach, D. H., and Laufman, H.: The Use of Intravenous Trypsin in Experimental Pulmonary Embolism , Surgery 35:45, 1954. 58. Ormand, L. H., and Knight, V.: Evaluation of Anticoagulant Therapy , Am. J. Med. 14:720, 1953. 59. Peck, M. E.: Preliminary Observations on the Effect of Trypsin Administered Intravenously , J. A. M. A. 154:1260, 1954. 60. Osborne, R.: Functioning Acinous Cell Carcinoma of the Pancreas Accompanied with Widespread Fat Necrosis , Arch. Int. Med. 85:933, 1950.Crossref 61. Perry, T. T.: Role of Lymphatic Vessels in Transmission of Lipase in Disseminated Fat Necrosis , Arch. Path. 43:456, 1947. 62. Konematsu, S.; Pack, G., and Stewart, F. W.: A Study of Enzyme Content of a Parenchymatous Adenocarcinoma of the Pancreas and a Comparison with Normal Human Pancreas , Am. J. Cancer 26: 351, 1936.Crossref 63. Belsky, H., and Cornell, N. W.: Disseminated Fat Necrosis Following Radical Pancreatico-Duodenectomy for Acinous Cancer of the Head of the Pancreas , Ann. Surg. 141:556, 1955.Crossref

Journal

A.M.A. Archives of Internal Medicine – American Medical Association

Published: Oct 1, 1955

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