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Three-Month Randomized Trial of Fixed-Combination Brinzolamide, 1%, and Brimonidine, 0.2%

Three-Month Randomized Trial of Fixed-Combination Brinzolamide, 1%, and Brimonidine, 0.2% CLINICAL TRIALS Three-Month Randomized Trial of Fixed-Combination Brinzolamide, 1%, and Brimonidine, 0.2% Gregory Katz, MD; Harvey DuBiner, MD; John Samples, MD; Steven Vold, MD; Kenneth Sall, MD Importance: This study evaluates the contribution of Main Outcomes and Measures: Mean IOP at the 3-month visit at all time points (8 AM,10 AM,3 PM, and the individual components of an investigational non–- 5 PM). antagonist fixed combination of brinzolamide, 1%, and brimonidine, 0.2%. This study and its sister study pro- Results: A total of 660 patients were enrolled. Baseline vide the first randomized data showing the intraocular mean IOP values were similar among treatment groups pressure (IOP)-lowering activity and the toxicity pro- at all 4 time points. At 3 months, the mean IOP of the file of this novel topical antihypertensive fixed combi- brinzolamide-brimonidine group (16.3-19.8 mm Hg) was nation. significantly lower than that of either the brinzolamide group (19.3-20.9 mm Hg; P.002) or the brimonidine Objective: To compare IOP-lowering efficacy of fixed- group (17.9-22.5 mm Hg; P.001) across all time points. combination brinzolamide, 1%, and brimonidine, 0.2%, One of 10 serious adverse events (chest pain, brinzo- with that of its components in patients with open-angle lamide group) was judged as http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Ophthalmology American Medical Association

Three-Month Randomized Trial of Fixed-Combination Brinzolamide, 1%, and Brimonidine, 0.2%

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Publisher
American Medical Association
Copyright
Copyright 2013 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6165
eISSN
2168-6173
DOI
10.1001/jamaophthalmol.2013.188
pmid
23579344
Publisher site
See Article on Publisher Site

Abstract

CLINICAL TRIALS Three-Month Randomized Trial of Fixed-Combination Brinzolamide, 1%, and Brimonidine, 0.2% Gregory Katz, MD; Harvey DuBiner, MD; John Samples, MD; Steven Vold, MD; Kenneth Sall, MD Importance: This study evaluates the contribution of Main Outcomes and Measures: Mean IOP at the 3-month visit at all time points (8 AM,10 AM,3 PM, and the individual components of an investigational non–- 5 PM). antagonist fixed combination of brinzolamide, 1%, and brimonidine, 0.2%. This study and its sister study pro- Results: A total of 660 patients were enrolled. Baseline vide the first randomized data showing the intraocular mean IOP values were similar among treatment groups pressure (IOP)-lowering activity and the toxicity pro- at all 4 time points. At 3 months, the mean IOP of the file of this novel topical antihypertensive fixed combi- brinzolamide-brimonidine group (16.3-19.8 mm Hg) was nation. significantly lower than that of either the brinzolamide group (19.3-20.9 mm Hg; P.002) or the brimonidine Objective: To compare IOP-lowering efficacy of fixed- group (17.9-22.5 mm Hg; P.001) across all time points. combination brinzolamide, 1%, and brimonidine, 0.2%, One of 10 serious adverse events (chest pain, brinzo- with that of its components in patients with open-angle lamide group) was judged as

Journal

JAMA OphthalmologyAmerican Medical Association

Published: Jun 1, 2013

References

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