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Three Differences Shown Between DNA Of Normal, Neoplastic Human Tissues

Three Differences Shown Between DNA Of Normal, Neoplastic Human Tissues At least three essential differences exist between the deoxyribonucleic acid (DNA) of normal and neoplastic human tissues, in vitro, a Buffalo research team has found. Although the significance of these differences is not yet clear, they open new potential avenues of attack for cancer chemotherapy, according to Julian L. Ambrus, MD, PhD. The DNA differences, reported by Dr. Ambrus at the American Society for Pharmacology and Experimental Therapeutics sessions in Philadelphia are: Neoplastic DNA has a smaller mean molecular weight:It has a more rigid configuration than normal DNA:It is a more efficient "primer" for new DNA than is the nucleic acid in a normal cell. "This last difference may be related to the increased growth rate of most cancers," he explained. "We are currently at work on developing drugs which would slow or inhibit this process." Tissues used in the Buffalo study were taken from patients scheduled for http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Three Differences Shown Between DNA Of Normal, Neoplastic Human Tissues

JAMA , Volume 193 (11) – Sep 13, 1965
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Publisher
American Medical Association
Copyright
Copyright © 1965 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1965.03090110139065
Publisher site
See Article on Publisher Site

Abstract

At least three essential differences exist between the deoxyribonucleic acid (DNA) of normal and neoplastic human tissues, in vitro, a Buffalo research team has found. Although the significance of these differences is not yet clear, they open new potential avenues of attack for cancer chemotherapy, according to Julian L. Ambrus, MD, PhD. The DNA differences, reported by Dr. Ambrus at the American Society for Pharmacology and Experimental Therapeutics sessions in Philadelphia are: Neoplastic DNA has a smaller mean molecular weight:It has a more rigid configuration than normal DNA:It is a more efficient "primer" for new DNA than is the nucleic acid in a normal cell. "This last difference may be related to the increased growth rate of most cancers," he explained. "We are currently at work on developing drugs which would slow or inhibit this process." Tissues used in the Buffalo study were taken from patients scheduled for

Journal

JAMA – American Medical Association

Published: Sep 13, 1965

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