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This Month in The Archives of Neurology

This Month in The Archives of Neurology Carotid Endarterectomy 1990-1995 Holloway and colleaguesArticle have measured patient outcomes for carotid endarterectomy from 1990 to 1995. They provide a rigorous assessment to guide future inpatient management "particularly in conditions when the margin of error is so low and the stakes are so high." Magnetic Resonance Imaging in Machado-Joseph Disease Quantitative assessment of magnetic resonance imaging scans in patients with Machado-Joseph disease is provided to characterize the typical neuroanatomical changes in this most common of dominantly inherited ataxias. The findings of Murata et alArticle correlate, in large measure, with the histopathological characteristics of this disease. HIV Encephalopathy Treated With Peptide T Heseltine and colleaguesArticle examined the effect of peptide T in patients with human immunodeficiency virus encephalopathy. Their assessment was rigorous, but peptide T was not found to be efficacious on the study's primary end points. Tiagabine for Complex Partial Seizures The new antiepileptic drug tiagabine, which inhibits uptake of γ-aminobutyric acid, was evaluated for use in complex seizures and was shown to be highly effective in a well-designed study by Uthman and colleaguesArticle. Mood Disorders and Multiple Sclerosis: Role of Cerebral Inflammation Fassbender et alArticle have investigated the association between affective and neuroendocrine changes in multiple sclerosis (MS) with inflammatory activity. Scores of depression and anxiety in patients with MS were associated with a failure of suppression of cortisol release after pretreatment with dexamethasone. A careful discussion about hypothalamic-pituitary-adrenal gland function in MS is reviewed as a potential link between cerebral inflammation and mood. Balance and Magnetic Resonance Imaging Changes Falling is a major cause of disability in older adults. Balance in elderly patients was studied in relation to changes demonstrated on magnetic resonance imaging scans. It appears that older adults with balance problems have a greater prevalence of brain abnormalities identified by magnetic resonance imaging, as presented by Tell and colleaguesArticle. Sense of Smell in Alzheimer's Disease and Parkinson's Disease Mesholam et alArticle found a pervasive impairment in olfactory function in patients with Alzheimer's disease and Parkinson's disease. No discriminating olfactory defects were seen between patient groups or among the 3 olfactory domains. It appears the olfactory system participates in the degenerative process in these 2 common neurological disorders. Selegiline in Amyotrophic Lateral Sclerosis Lange and colleaguesArticle have studied the use of selegiline hydrochloride, a monoamine oxidase-B inhibitor, in patients with amyotrophic lateral sclerosis. Unfortunately, no significant effect on the rate of clinical progression or outcome of disease was found. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology American Medical Association

This Month in The Archives of Neurology

Archives of Neurology , Volume 55 (1) – Jan 1, 1998

This Month in The Archives of Neurology

Abstract

Carotid Endarterectomy 1990-1995 Holloway and colleaguesArticle have measured patient outcomes for carotid endarterectomy from 1990 to 1995. They provide a rigorous assessment to guide future inpatient management "particularly in conditions when the margin of error is so low and the stakes are so high." Magnetic Resonance Imaging in Machado-Joseph Disease Quantitative assessment of magnetic resonance imaging scans in patients with Machado-Joseph disease is provided to characterize...
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Publisher
American Medical Association
Copyright
Copyright © 1998 American Medical Association. All Rights Reserved.
ISSN
0003-9942
eISSN
1538-3687
DOI
10.1001/archneur.55.1.15
Publisher site
See Article on Publisher Site

Abstract

Carotid Endarterectomy 1990-1995 Holloway and colleaguesArticle have measured patient outcomes for carotid endarterectomy from 1990 to 1995. They provide a rigorous assessment to guide future inpatient management "particularly in conditions when the margin of error is so low and the stakes are so high." Magnetic Resonance Imaging in Machado-Joseph Disease Quantitative assessment of magnetic resonance imaging scans in patients with Machado-Joseph disease is provided to characterize the typical neuroanatomical changes in this most common of dominantly inherited ataxias. The findings of Murata et alArticle correlate, in large measure, with the histopathological characteristics of this disease. HIV Encephalopathy Treated With Peptide T Heseltine and colleaguesArticle examined the effect of peptide T in patients with human immunodeficiency virus encephalopathy. Their assessment was rigorous, but peptide T was not found to be efficacious on the study's primary end points. Tiagabine for Complex Partial Seizures The new antiepileptic drug tiagabine, which inhibits uptake of γ-aminobutyric acid, was evaluated for use in complex seizures and was shown to be highly effective in a well-designed study by Uthman and colleaguesArticle. Mood Disorders and Multiple Sclerosis: Role of Cerebral Inflammation Fassbender et alArticle have investigated the association between affective and neuroendocrine changes in multiple sclerosis (MS) with inflammatory activity. Scores of depression and anxiety in patients with MS were associated with a failure of suppression of cortisol release after pretreatment with dexamethasone. A careful discussion about hypothalamic-pituitary-adrenal gland function in MS is reviewed as a potential link between cerebral inflammation and mood. Balance and Magnetic Resonance Imaging Changes Falling is a major cause of disability in older adults. Balance in elderly patients was studied in relation to changes demonstrated on magnetic resonance imaging scans. It appears that older adults with balance problems have a greater prevalence of brain abnormalities identified by magnetic resonance imaging, as presented by Tell and colleaguesArticle. Sense of Smell in Alzheimer's Disease and Parkinson's Disease Mesholam et alArticle found a pervasive impairment in olfactory function in patients with Alzheimer's disease and Parkinson's disease. No discriminating olfactory defects were seen between patient groups or among the 3 olfactory domains. It appears the olfactory system participates in the degenerative process in these 2 common neurological disorders. Selegiline in Amyotrophic Lateral Sclerosis Lange and colleaguesArticle have studied the use of selegiline hydrochloride, a monoamine oxidase-B inhibitor, in patients with amyotrophic lateral sclerosis. Unfortunately, no significant effect on the rate of clinical progression or outcome of disease was found.

Journal

Archives of NeurologyAmerican Medical Association

Published: Jan 1, 1998

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