Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Thiabendazole-Induced Toxic Epidermal Necrolysis

Thiabendazole-Induced Toxic Epidermal Necrolysis Abstract • Toxic epidermal necrolysis (TEN) is a syndrome that may develop from a number of different stimuli, including drug administration, staphylococcal infection, vaccine administration, and blood dyscrasias. A 29-year-old woman developed TEN from the systemic administration of thiabendazole. Although various cutaneous adverse reactions have been attributed to the administration of this medication, this is the first case to indicate that orally administered thiabendazole may also produce TEN. Although acutely ill at the time of hospitalization, the patient showed a prompt response to treatment with prednisone. (Arch Dermatol 112:1757-1760, 1976) References 1. Lyell A: Toxic epidermal necrolysis: An eruption resembling scalding of the skin . Br J Dermatol 68:355-361, 1956.Crossref 2. Lang R, Walker J: An unusual bullous eruption . S Arf Med J 30:97-98, 1956. 3. Tyson RG, Ushinski SC, Kisilevsky R: Toxic epidermal necrolysis (the scalded skin syndrome) . Am J Dis Child 111:386-392, 1966.Crossref 4. Jefferson J: Lyell's toxic epidermal necrolysis: A staphylococcal etiology . Br Med J 2:802-804, 1967.Crossref 5. Lowney ED, Banblis JV, Kreye GM, et al: The scalded skin syndrome in small children . Arch Dermatol 95:359-369, 1967.Crossref 6. Koblenzer PJ: Acute epidermal necrolysis (Ritter von Rittershain-Lyell) . Arch Dermatol 95:608-617, 1967.Crossref 7. Ritter von Rittershain C: Die exfoliative Dermatitis jungerer Sauglinge . Centralzeit Kinderheilkd 2:3-23, 1878. 8. Sloss RG, Rayhanzadeh S: Toxic epidermal necrolysis following measles vaccination . Arch Dermatol 110:766-770, 1974.Crossref 9. Product information circular on thiabendazole. Merck, Sharp and Dohme. 10. Brown H: The chemistry of thiabendazole . Tex Rep Biol Med 27:533-536, 1969. 11. Eaton LG, Siegmund OH, Rankin AO, et al: The veterinary uses of thiabendazole . Tex Rep Biol Med 27:697-708, 1969. 12. Franz KH: Clinical trials with thiabendazole against intestinal nematodes infecting humans . Am J Trop Med Hyg 14:383-386, 1965. 13. Most H, Yoeli M, Campbell WC, et al: The treatment of Strongyloides and Enterobius infection with thiabendazole . Am J Trop Med 14:379-382, 1965. 14. Davis H: Pinworm infestation-therapy with thiabendazole . Tex Rep Biol Med 27:623-627, 1969. 15. Egerton JR: The ovicidal and larvicidal effect of thiabendazole on various helminth species . Tex Rep Biol Med 27:561-580, 1969. 16. Kotcher E, Chavarria AP, Gamboa JA, et al: Community control of intestinal nematodes by thiabendazole treatment . Tex Rep Biol Med 27:629-643, 1969. 17. Chuttani HK, Chouri MAK: Thiabendazole and related compounds in treatment of hookworm infestation . Tex Rep Biol Med 27:597-600, 1969. 18. Stone OJ: Systemic and topical thiabendazole for creeping eruption . Tex Rep Biol Med 27:659-663, 1969. 19. Battistini F: Treatment of creeping eruption with topical thiabendazole . Tex Rep Biol Med 27:644-658, 1969. 20. Hennekeuser HH, Pabst K, Poeplan W, et al: Thiabendazole for the treatment of trichinosis in humans . Tex Rep Biol Med 27:581-596, 1969. 21. Campbell WC, Cuckler AC: Thiabendazole in the treatment and control of parasite infections in man . Tex Rep Biol Med 27:665-692, 1969. 22. Franz KH: Clinical trials of thiabendazole against human strongyloidiasis . Am J Trop Med Hyg 12:211-214, 1963. 23. Salunkhe DS, Gaitorde BB, Vakil BJ: Clinical evaluation of a new antihelmintic thiabendazole 2-(4′ thiazolyl) benzimidazole . Am J Trop Med 13:412-416, 1964. 24. Stuart JE, Welch JS: Treatment of trichinosis with thiabendazole . Med J Aust 2:1017-1019, 1973. 25. Robinson HJ, Silber RH, Graessle OE: Thiabendazole: Toxicological, pharmacological and antifungal properties . Tex Rep Biol Med 27:537-560, 1969. 26. Katz R, Ziegler J, Blank H: The natural course of creeping eruption and treatment with thiabendazole . Arch Dermatol 91:420-424, 1965.Crossref 27. Stone OJ, Mullins JF: Thiabendazole-effectiveness in creeping eruption . Arch Dermatol 91:427-429, 1965.Crossref 28. Huang OH, Brown HSW: The efficacy of thiabendazole against hookworm and ascaris of man . J Parsitol 49:1014-1018, 1963.Crossref 29. Jacksonville Dermatologic Society: Creeping eruption treatment with thiabendazole . Arch Dermatol 91:425-426, 1965.Crossref 30. Kean BH, Hoskins DW: Treatment of trichinosis with thiabendazole: A preliminary report . JAMA 190:852-853, 1964.Crossref 31. Rist TE, Abele DC: Current concepts of toxic epidermal necrolysis . South Med J 68:22-26, 1975.Crossref 32. Radimer GF, Davis JH, Ackerman AB: Fumigant induced toxic epidermal necrolysis . Arch Dermatol 110:103-104, 1974.Crossref 33. Calloway JL, Tate WE: Toxic epidermal necrolysis caused by "gin and tonic." Arch Dermatol 109:909, 1974.Crossref 34. Lyell A: A review of toxic epidermal necrolysis in Britain . Br J Dermatol 79:662-671, 1967.Crossref 35. Lyell A: Toxic epidermal necrolysis resembling scaling of the skin . Br J Dermatol 68:355-361, 1960.Crossref 36. Lyell A, et al: Outbreak of toxic epidermal necrolysis associated with staphylococci . Lancet 1:787-798, 1969.Crossref 37. Peck GC, Herzig GP, Elias PM: Toxic epidermal necrolysis in a patient with graft-vs-host reaction . Arch Dermatol 105:561-569, 1972.Crossref 38. Amman AJ, et al: Toxic epidermal necrolysis . Lancet 2:248-249, 1972. 39. Billingham RE, Strelein JW: TEN and homologous disease in hamsters . Arch Dermatol 98:528-539, 1968.Crossref 40. Balner H, de Vries MJ, van Bekkum DW: Secondary disease in rat radiation chimeras . J Natl Cancer Inst 32:419-459, 1964. 41. Merritt CB, Darrow CC, Vaal L, et al: Bone marrow transplantation on rhesus monkeys following irradiation . Transplantation 14:9-20, 1972.Crossref 42. Whipper KD, Dimond RL, Knutson DD: Studies of the mechanism of epidermal injury by a staphylococcal epidermolytic toxin . J Invest Dermatol 65:191-200, 1975.Crossref 43. Strelein JW: An analysis of epidermolysis in hamsters suffering from homologous disease , in Montagna W, Billingham RE (eds): Advances in Biology of Skin. vol 11, Immunology and the Skin . New York, Appleton-Century-Crofts, Inc, 1971, pp 213-222. 44. Braun-Falco O, Wolff H: Zur Ultrastruktur der Epidermis beim Lyell Syndrom . Arch Klin Exp Dermatol 236:83-96, 1969.Crossref 45. Nasimann T, Lee S: Electronenmikroskopische Befunde beim Lyell-Syndrom . Hautarzt 23:199-204, 1972. 46. de Dobbeleer G, Achten G: Staphylococcal Scalded Skin syndrome: An ultrastructural study . J Cutan Pathol 2:91-96, 1975.Crossref 47. Ohlenschlaeger K: Toxic epidermal necrolysis and Stevens Johnson disease . Acta Derm Venereol 46:205-209, 1966. 48. Bjornberg A, Bjornberg K, Gisslen H: Toxic epidermal necrolysis with ophthalmic complications . Acta Ophthalmol 42:1084-1095, 1964.Crossref 49. Rousselst R, Labrum C: Erythema multiforme (Stevens Johnson Syndrome) with dermatitis exfoliativa . Bull Soc Fr Dermatol Syphilol 71:672-675, 1964. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Thiabendazole-Induced Toxic Epidermal Necrolysis

Loading next page...
 
/lp/american-medical-association/thiabendazole-induced-toxic-epidermal-necrolysis-60gKaJvXY0
Publisher
American Medical Association
Copyright
Copyright © 1976 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1976.01630370045011
Publisher site
See Article on Publisher Site

Abstract

Abstract • Toxic epidermal necrolysis (TEN) is a syndrome that may develop from a number of different stimuli, including drug administration, staphylococcal infection, vaccine administration, and blood dyscrasias. A 29-year-old woman developed TEN from the systemic administration of thiabendazole. Although various cutaneous adverse reactions have been attributed to the administration of this medication, this is the first case to indicate that orally administered thiabendazole may also produce TEN. Although acutely ill at the time of hospitalization, the patient showed a prompt response to treatment with prednisone. (Arch Dermatol 112:1757-1760, 1976) References 1. Lyell A: Toxic epidermal necrolysis: An eruption resembling scalding of the skin . Br J Dermatol 68:355-361, 1956.Crossref 2. Lang R, Walker J: An unusual bullous eruption . S Arf Med J 30:97-98, 1956. 3. Tyson RG, Ushinski SC, Kisilevsky R: Toxic epidermal necrolysis (the scalded skin syndrome) . Am J Dis Child 111:386-392, 1966.Crossref 4. Jefferson J: Lyell's toxic epidermal necrolysis: A staphylococcal etiology . Br Med J 2:802-804, 1967.Crossref 5. Lowney ED, Banblis JV, Kreye GM, et al: The scalded skin syndrome in small children . Arch Dermatol 95:359-369, 1967.Crossref 6. Koblenzer PJ: Acute epidermal necrolysis (Ritter von Rittershain-Lyell) . Arch Dermatol 95:608-617, 1967.Crossref 7. Ritter von Rittershain C: Die exfoliative Dermatitis jungerer Sauglinge . Centralzeit Kinderheilkd 2:3-23, 1878. 8. Sloss RG, Rayhanzadeh S: Toxic epidermal necrolysis following measles vaccination . Arch Dermatol 110:766-770, 1974.Crossref 9. Product information circular on thiabendazole. Merck, Sharp and Dohme. 10. Brown H: The chemistry of thiabendazole . Tex Rep Biol Med 27:533-536, 1969. 11. Eaton LG, Siegmund OH, Rankin AO, et al: The veterinary uses of thiabendazole . Tex Rep Biol Med 27:697-708, 1969. 12. Franz KH: Clinical trials with thiabendazole against intestinal nematodes infecting humans . Am J Trop Med Hyg 14:383-386, 1965. 13. Most H, Yoeli M, Campbell WC, et al: The treatment of Strongyloides and Enterobius infection with thiabendazole . Am J Trop Med 14:379-382, 1965. 14. Davis H: Pinworm infestation-therapy with thiabendazole . Tex Rep Biol Med 27:623-627, 1969. 15. Egerton JR: The ovicidal and larvicidal effect of thiabendazole on various helminth species . Tex Rep Biol Med 27:561-580, 1969. 16. Kotcher E, Chavarria AP, Gamboa JA, et al: Community control of intestinal nematodes by thiabendazole treatment . Tex Rep Biol Med 27:629-643, 1969. 17. Chuttani HK, Chouri MAK: Thiabendazole and related compounds in treatment of hookworm infestation . Tex Rep Biol Med 27:597-600, 1969. 18. Stone OJ: Systemic and topical thiabendazole for creeping eruption . Tex Rep Biol Med 27:659-663, 1969. 19. Battistini F: Treatment of creeping eruption with topical thiabendazole . Tex Rep Biol Med 27:644-658, 1969. 20. Hennekeuser HH, Pabst K, Poeplan W, et al: Thiabendazole for the treatment of trichinosis in humans . Tex Rep Biol Med 27:581-596, 1969. 21. Campbell WC, Cuckler AC: Thiabendazole in the treatment and control of parasite infections in man . Tex Rep Biol Med 27:665-692, 1969. 22. Franz KH: Clinical trials of thiabendazole against human strongyloidiasis . Am J Trop Med Hyg 12:211-214, 1963. 23. Salunkhe DS, Gaitorde BB, Vakil BJ: Clinical evaluation of a new antihelmintic thiabendazole 2-(4′ thiazolyl) benzimidazole . Am J Trop Med 13:412-416, 1964. 24. Stuart JE, Welch JS: Treatment of trichinosis with thiabendazole . Med J Aust 2:1017-1019, 1973. 25. Robinson HJ, Silber RH, Graessle OE: Thiabendazole: Toxicological, pharmacological and antifungal properties . Tex Rep Biol Med 27:537-560, 1969. 26. Katz R, Ziegler J, Blank H: The natural course of creeping eruption and treatment with thiabendazole . Arch Dermatol 91:420-424, 1965.Crossref 27. Stone OJ, Mullins JF: Thiabendazole-effectiveness in creeping eruption . Arch Dermatol 91:427-429, 1965.Crossref 28. Huang OH, Brown HSW: The efficacy of thiabendazole against hookworm and ascaris of man . J Parsitol 49:1014-1018, 1963.Crossref 29. Jacksonville Dermatologic Society: Creeping eruption treatment with thiabendazole . Arch Dermatol 91:425-426, 1965.Crossref 30. Kean BH, Hoskins DW: Treatment of trichinosis with thiabendazole: A preliminary report . JAMA 190:852-853, 1964.Crossref 31. Rist TE, Abele DC: Current concepts of toxic epidermal necrolysis . South Med J 68:22-26, 1975.Crossref 32. Radimer GF, Davis JH, Ackerman AB: Fumigant induced toxic epidermal necrolysis . Arch Dermatol 110:103-104, 1974.Crossref 33. Calloway JL, Tate WE: Toxic epidermal necrolysis caused by "gin and tonic." Arch Dermatol 109:909, 1974.Crossref 34. Lyell A: A review of toxic epidermal necrolysis in Britain . Br J Dermatol 79:662-671, 1967.Crossref 35. Lyell A: Toxic epidermal necrolysis resembling scaling of the skin . Br J Dermatol 68:355-361, 1960.Crossref 36. Lyell A, et al: Outbreak of toxic epidermal necrolysis associated with staphylococci . Lancet 1:787-798, 1969.Crossref 37. Peck GC, Herzig GP, Elias PM: Toxic epidermal necrolysis in a patient with graft-vs-host reaction . Arch Dermatol 105:561-569, 1972.Crossref 38. Amman AJ, et al: Toxic epidermal necrolysis . Lancet 2:248-249, 1972. 39. Billingham RE, Strelein JW: TEN and homologous disease in hamsters . Arch Dermatol 98:528-539, 1968.Crossref 40. Balner H, de Vries MJ, van Bekkum DW: Secondary disease in rat radiation chimeras . J Natl Cancer Inst 32:419-459, 1964. 41. Merritt CB, Darrow CC, Vaal L, et al: Bone marrow transplantation on rhesus monkeys following irradiation . Transplantation 14:9-20, 1972.Crossref 42. Whipper KD, Dimond RL, Knutson DD: Studies of the mechanism of epidermal injury by a staphylococcal epidermolytic toxin . J Invest Dermatol 65:191-200, 1975.Crossref 43. Strelein JW: An analysis of epidermolysis in hamsters suffering from homologous disease , in Montagna W, Billingham RE (eds): Advances in Biology of Skin. vol 11, Immunology and the Skin . New York, Appleton-Century-Crofts, Inc, 1971, pp 213-222. 44. Braun-Falco O, Wolff H: Zur Ultrastruktur der Epidermis beim Lyell Syndrom . Arch Klin Exp Dermatol 236:83-96, 1969.Crossref 45. Nasimann T, Lee S: Electronenmikroskopische Befunde beim Lyell-Syndrom . Hautarzt 23:199-204, 1972. 46. de Dobbeleer G, Achten G: Staphylococcal Scalded Skin syndrome: An ultrastructural study . J Cutan Pathol 2:91-96, 1975.Crossref 47. Ohlenschlaeger K: Toxic epidermal necrolysis and Stevens Johnson disease . Acta Derm Venereol 46:205-209, 1966. 48. Bjornberg A, Bjornberg K, Gisslen H: Toxic epidermal necrolysis with ophthalmic complications . Acta Ophthalmol 42:1084-1095, 1964.Crossref 49. Rousselst R, Labrum C: Erythema multiforme (Stevens Johnson Syndrome) with dermatitis exfoliativa . Bull Soc Fr Dermatol Syphilol 71:672-675, 1964.

Journal

Archives of DermatologyAmerican Medical Association

Published: Dec 1, 1976

References