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Thiabendazole Effects in Visceral Larva Migrans

Thiabendazole Effects in Visceral Larva Migrans To the Editor.— It has been postulated that antiinflammatory, antipyretic, and analgesic effects may contribute to the clinical response that is often observed in the treatment of trichinosis with thiabendazole.1 These nonspecific pharmacologic effects, thus far demonstrated only in laboratory animals, may also contribute to the clinical response seen in the treatment of certain other helminth and mycotic infections. In several cases of visceral larva migrans, thiabendazole treatment was followed promptly by an amelioration of symptoms, including the reduction of fever.2-4 In one of these cases,2 the response was characterized by defervescence with recurrence of fever on two occasions when treatment was interrupted, and defervescence when treatment was resumed. This response may have been due to a subcurative anthelmintic action; but, it could also be explained partially or even totally on the basis of nonspecific effects. In other cases,3 treatment was followed by prompt alleviation of http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Thiabendazole Effects in Visceral Larva Migrans

Campbell, William C.
JAMA , Volume 217 (3) – Jul 19, 1971
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References (6)

Publisher
American Medical Association
Copyright
Copyright © 1971 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1971.03190030066027
Publisher site
See Article on Publisher Site

Abstract

To the Editor.— It has been postulated that antiinflammatory, antipyretic, and analgesic effects may contribute to the clinical response that is often observed in the treatment of trichinosis with thiabendazole.1 These nonspecific pharmacologic effects, thus far demonstrated only in laboratory animals, may also contribute to the clinical response seen in the treatment of certain other helminth and mycotic infections. In several cases of visceral larva migrans, thiabendazole treatment was followed promptly by an amelioration of symptoms, including the reduction of fever.2-4 In one of these cases,2 the response was characterized by defervescence with recurrence of fever on two occasions when treatment was interrupted, and defervescence when treatment was resumed. This response may have been due to a subcurative anthelmintic action; but, it could also be explained partially or even totally on the basis of nonspecific effects. In other cases,3 treatment was followed by prompt alleviation of

Journal

JAMA – American Medical Association

Published: Jul 19, 1971

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