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Therapy With Keratolytic Gel and Corticosteroid Ointment

Therapy With Keratolytic Gel and Corticosteroid Ointment Abstract To the Editor.— I would like to respond to a number of inquiries regarding the use of a keratolytic gel and corticosteroid ointment1 in treating generalized psoriasis. The failure of many topically applied agents to clear psoriatic plaques results in part from slow penetration through the hyperkeratotic surface of the skin. In a similar manner, the thickened abnormal stratum corneum may limit the response to ultraviolet light (UV) treatment.We have previously reported that hyperkeratotic dermatoses of the palms and soles improve more completely by combining the use of a salicylic acid-propylene glycol keratolytic gel with a corticosteroid ointment in a sequential fashion.1 Using a similar technique, we have found that this combination is more effective than steroid ointment alone in treating generalized psoriasis. To test the combination, we applied keratolytic gel, occluded the area for 1½ hours and followed this with steroid ointment under occlusion overnight on References 1. Baden HP: A new regimen for the treatment of psoriasis . Cutis , to be published. 2. Tanenbaum L, Parrish JA, Pathak MA, et al: Tar phototoxicity and phototherapy for psoriasis . Arch Dermatol 111:467-470, 1975.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Therapy With Keratolytic Gel and Corticosteroid Ointment

Archives of Dermatology , Volume 111 (11) – Nov 1, 1975

Therapy With Keratolytic Gel and Corticosteroid Ointment

Abstract

Abstract To the Editor.— I would like to respond to a number of inquiries regarding the use of a keratolytic gel and corticosteroid ointment1 in treating generalized psoriasis. The failure of many topically applied agents to clear psoriatic plaques results in part from slow penetration through the hyperkeratotic surface of the skin. In a similar manner, the thickened abnormal stratum corneum may limit the response to ultraviolet light (UV) treatment.We have previously reported that...
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Publisher
American Medical Association
Copyright
Copyright © 1975 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1975.01630230134029
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor.— I would like to respond to a number of inquiries regarding the use of a keratolytic gel and corticosteroid ointment1 in treating generalized psoriasis. The failure of many topically applied agents to clear psoriatic plaques results in part from slow penetration through the hyperkeratotic surface of the skin. In a similar manner, the thickened abnormal stratum corneum may limit the response to ultraviolet light (UV) treatment.We have previously reported that hyperkeratotic dermatoses of the palms and soles improve more completely by combining the use of a salicylic acid-propylene glycol keratolytic gel with a corticosteroid ointment in a sequential fashion.1 Using a similar technique, we have found that this combination is more effective than steroid ointment alone in treating generalized psoriasis. To test the combination, we applied keratolytic gel, occluded the area for 1½ hours and followed this with steroid ointment under occlusion overnight on References 1. Baden HP: A new regimen for the treatment of psoriasis . Cutis , to be published. 2. Tanenbaum L, Parrish JA, Pathak MA, et al: Tar phototoxicity and phototherapy for psoriasis . Arch Dermatol 111:467-470, 1975.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Nov 1, 1975

References

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