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Therapy of Experimental Vaccinal Keratitis: Effect of Idoxuridine and VIG

Therapy of Experimental Vaccinal Keratitis: Effect of Idoxuridine and VIG Abstract Introduction One of the less common, but serious complications of smallpox vaccination is accidental inoculation of the cornea with vaccinia virus. Acute inflammatory changes associated with prolonged disability due to corneal clouding can follow vaccinal keratitis.1 Various modes of therapy have been employed.1-3 For these reasons, a systematic attempt was made to evaluate two of the more recently employed therapeutic regimens, and the results are the basis of this report. Materials Rabbits. —Four-week-old Swiss albino rabbits weighing approximately 1 kg were obtained from a local rabbitry.* Animals were observed for several days prior to beginning an experiment as occasional rabbits did not survive abrupt weaning. Virus. —Several vaccinia strains were employed in preliminary studies and variable corneal infection rates and severity were noted with all but a tissue-culture adapted calf-lymph-origin strain. A commercial product † prepared in calf skin and packaged in capillary tubes was obtained. Twelve capillary References 1. Dale's Rabbitry, Denver, Colo. 2. Wyeth Laboratories. 3. Flow Laboratories, Bethesda, Md. 4. Supplied by Dr. James Pert, Director, American National Red Cross Blood Bank Program. 5. Cutter Laboratories, Berkeley, California. 6. Idoxuridine supplied as Stoxil—SKF 14287—by Smith, Kline, and French. 7. Ellis, P.P., and Winograd, L.A.: Ocular Vaccinia: A Specific Treatment , Arch Ophthal 68:600, 1962.Crossref 8. Kempe, C.H.: Studies on Smallpox and Complications of Smallpox Vaccination , Pediatrics 26:176, 1960. 9. Kaufman, H.; Nesburn, A.B.; and Maloney, E.D.: Cure of Vaccinia Infection by 5-iodo 2′deoxyuridine , Virology 18:567, 1962.Crossref 10. Kaufman, H.: Treatment of Herpes Simplex and Vaccinia Keratitis with 5-iodo and 5-bromo 2′ deoxyuridine , Perspect Virol 3:90, 1963. 11. Unpublished observations. 12. Jack, M.K., and Sorenson, R.W.: Vaccinal Keratitis Treated With IDU , Arch Ophthal 69:730, 1963.Crossref 13. Jones, B.R.; Gailbraith, J.E.K.; and Alhussain, K.M.: Vaccinal Keratitis Treated with Interferon , Lancet 1:875, 1962.Crossref 14. Focasi, M., et al: Our Present Experience with 5-iodo 2′deoxyuridine (IDU) in Ophthalmology , Ophthalmologica 146:1991963.Crossref 15. Lepri, G., and Parducci, F.: La 5-iodo 2′deossiuridina nella cheratite vaccinica sperimentale , Ann Oftal 88:443, 1962. 16. Gordon, D.M., and Advocate, S.: Vaccinial Blepharokeratitis, Treated with Cytosine Arabinoside , Amer J Ophthal 59:480, 1965. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Therapy of Experimental Vaccinal Keratitis: Effect of Idoxuridine and VIG

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Publisher
American Medical Association
Copyright
Copyright © 1965 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1965.00970040541019
Publisher site
See Article on Publisher Site

Abstract

Abstract Introduction One of the less common, but serious complications of smallpox vaccination is accidental inoculation of the cornea with vaccinia virus. Acute inflammatory changes associated with prolonged disability due to corneal clouding can follow vaccinal keratitis.1 Various modes of therapy have been employed.1-3 For these reasons, a systematic attempt was made to evaluate two of the more recently employed therapeutic regimens, and the results are the basis of this report. Materials Rabbits. —Four-week-old Swiss albino rabbits weighing approximately 1 kg were obtained from a local rabbitry.* Animals were observed for several days prior to beginning an experiment as occasional rabbits did not survive abrupt weaning. Virus. —Several vaccinia strains were employed in preliminary studies and variable corneal infection rates and severity were noted with all but a tissue-culture adapted calf-lymph-origin strain. A commercial product † prepared in calf skin and packaged in capillary tubes was obtained. Twelve capillary References 1. Dale's Rabbitry, Denver, Colo. 2. Wyeth Laboratories. 3. Flow Laboratories, Bethesda, Md. 4. Supplied by Dr. James Pert, Director, American National Red Cross Blood Bank Program. 5. Cutter Laboratories, Berkeley, California. 6. Idoxuridine supplied as Stoxil—SKF 14287—by Smith, Kline, and French. 7. Ellis, P.P., and Winograd, L.A.: Ocular Vaccinia: A Specific Treatment , Arch Ophthal 68:600, 1962.Crossref 8. Kempe, C.H.: Studies on Smallpox and Complications of Smallpox Vaccination , Pediatrics 26:176, 1960. 9. Kaufman, H.; Nesburn, A.B.; and Maloney, E.D.: Cure of Vaccinia Infection by 5-iodo 2′deoxyuridine , Virology 18:567, 1962.Crossref 10. Kaufman, H.: Treatment of Herpes Simplex and Vaccinia Keratitis with 5-iodo and 5-bromo 2′ deoxyuridine , Perspect Virol 3:90, 1963. 11. Unpublished observations. 12. Jack, M.K., and Sorenson, R.W.: Vaccinal Keratitis Treated With IDU , Arch Ophthal 69:730, 1963.Crossref 13. Jones, B.R.; Gailbraith, J.E.K.; and Alhussain, K.M.: Vaccinal Keratitis Treated with Interferon , Lancet 1:875, 1962.Crossref 14. Focasi, M., et al: Our Present Experience with 5-iodo 2′deoxyuridine (IDU) in Ophthalmology , Ophthalmologica 146:1991963.Crossref 15. Lepri, G., and Parducci, F.: La 5-iodo 2′deossiuridina nella cheratite vaccinica sperimentale , Ann Oftal 88:443, 1962. 16. Gordon, D.M., and Advocate, S.: Vaccinial Blepharokeratitis, Treated with Cytosine Arabinoside , Amer J Ophthal 59:480, 1965.

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Oct 1, 1965

References