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Therapeutic Spectrum of Uracil-Mustard, A New Oral Antitumor Drug

Therapeutic Spectrum of Uracil-Mustard, A New Oral Antitumor Drug One hundred and thirty patients with various neoplastic disorders were treated with uracil-mustard (U-8344), a new oral alkylating agent with a therapeutic spectrum similar to that of other mustard analogues. This agent was especially effective in treatment of lymphomas and chronic leukemias. Occasionally solid tumors, notably ovarian carcinoma, responded. Advantages of uracil-mustard over other similar agents are: (1) the small dosage required to obtain beneficial results; (2) uniform tolerability; and (3) simplicity of the regimen. With judicious administration long-term therapy may be carried out with continued benefit. The study suggested that the drug may be of value when other alkylating agents have failed. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Therapeutic Spectrum of Uracil-Mustard, A New Oral Antitumor Drug

Shanbrom, Edward; Miller, Sherwood; Haar, Helmut; Opfell, Richard
JAMA , Volume 174 (13) – Nov 26, 1960
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References (1)

Publisher
American Medical Association
Copyright
Copyright © 1960 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1960.03030130030008
Publisher site
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Abstract

One hundred and thirty patients with various neoplastic disorders were treated with uracil-mustard (U-8344), a new oral alkylating agent with a therapeutic spectrum similar to that of other mustard analogues. This agent was especially effective in treatment of lymphomas and chronic leukemias. Occasionally solid tumors, notably ovarian carcinoma, responded. Advantages of uracil-mustard over other similar agents are: (1) the small dosage required to obtain beneficial results; (2) uniform tolerability; and (3) simplicity of the regimen. With judicious administration long-term therapy may be carried out with continued benefit. The study suggested that the drug may be of value when other alkylating agents have failed.

Journal

JAMA – American Medical Association

Published: Nov 26, 1960

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