Abstract For years, in going over the literature on corneal ulcer, I have noticed that all standard textbooks agree on one point—that corneal ulcer is a malignant disease and when due to Bacillus pyocyaneus usually leads to loss of the eye or at least to loss of sight. These facts made little impression on me until the summer of 1942, when I encountered 3 cases of B. pyocyaneus corneal ulcer, and the experience with these cases is herein reported. It may seem illogical to draw any conclusion from 3 cases ; however, such ulcer is extremely rare. Joy,1 reporting in June 1942, said that only 64 cases had been reported in the literature, 23 of them having been reported since 1922. A tabulation showed loss of the eyeball in 12, total loss of sight in 3, loss of sight to 1/10 in 4 and reduction of vision in 4. Joy gave References 1. Joy, H. H.: Treatment of Experimental Bacillus Pyocyaneus Ulcer of Cornea with Sulfapyridine , Arch. Ophth. 27:1135-1164 ( (June) ) 1942.Crossref 2. Liebman, S. D., and Newman, E. H.: Distribution of Sulfanilamide and Its Derivatives Between Blood and Aqueous , Arch. Ophth. 26:472-477 ( (Sept.) ) 1941.Crossref 3. Scheie, H. G., and Leopold, I. H.: Penetration of Sulfathiazole into the Eye , Arch. Ophth. 27:997-1004 ( (May) ) 1942.Crossref 4. Chinn, H., and Bellows, J. G.: Corneal Penetration of Sulfanilamide and Some of Its Derivatives , Arch. Ophth. 27:34-39 ( (June) ) 1942.Crossref 5. Osgood, E. E.: Principles Which Should Govern the Local Use of the Sulfanilamide Drugs , Surg., Gynec. & Obst. 75:21-27 ( (July) ) 1942. 6. Lepard, C. W.: Bacillus Pyocyaneus Ulcer : Report of Three Cases; Results of Sulfapyridine Therapy in One Case , Tr. Am. Acad. Ophth. 46:55-60 ( (Nov.-Dec.) ) 1941.
Archives of Ophthalmology – American Medical Association
Published: Aug 1, 1943
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