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THE VOLUME OF BLOOD FLOW PER MINUTE THROUGH THE LUNGS FOLLOWING COLLAPSE OF ONE LUNG BY OCCLUSION OF ITS BRONCHUS: EXPERIMENTAL OBSERVATIONS

THE VOLUME OF BLOOD FLOW PER MINUTE THROUGH THE LUNGS FOLLOWING COLLAPSE OF ONE LUNG BY OCCLUSION... Abstract The effect of atelectasis1 of a lung on the pulmonary blood circulation became particularly interesting with the introduction of pneumothorax in the treatment for certain types of pulmonary tuberculosis. The significance of this relationship has increased in importance with the development of thoracic surgery, because there are few, if any, surgical procedures within the thoracic cavity or involving the thoracic wall that do not affect the expansion of the lungs. In spite of many experimental studies, however, there is no uniform agreement as to the exact nature of the resulting circulatory changes. Different investigators have arrived at conclusions that are diametrically opposed to each other, and the present status of knowledge is at best confusing and nonconvincing. The contradictory results are in part due to the fact that so far it has not been possible to determine by direct measurement the amount of blood that passes through a lung. References 1. Coryllos and Birnbaum ( Obstructive Massive Atelectasis of the Lung ; Arch. Surg. 16:501 [ (Jan.) ] 1928)Crossref 2. Bruns, O.: Untersuchungen über den respiratorischen Gaswechsel bei Erkrankungen der Lunge und der luftzuführenden Wege , Deutsches Arch. f. klin. Med. 107:468, 1912. 3. Graham, E. A., and Bell, R. D.: Open Pneumothorax: Its Relation to the Treatment of Empyema , Am. J. M. Sc. 156:839, 1918.Crossref 4. Loewy, A., and von Schrötter, H.: Untersuchungen über die Blutcirkulation beim Menschen , Ztschr. f. exper. Path. u. Therap. 1:197, 1905.Crossref 5. Hess, R.: Ueber die Durchblutung nicht atmender Lungengebiete , Deutsches Arch. f. klin. Med. 106:478, 1912. 6. In this calculation the oxygen content of the blood from the breathing lung (right lung) is assumed to be the same as the control arterial oxygen content. The formula from which the calculation is made is given in the paragraph which describes the experiments of Weiss. 7. Adams, D. K., and Morris, N.: Anoxaemia and the Administration of Oxygen , J. Physiol. (Proc. Physiol. Soc.) 54:102-104; 106-107, 1921. 8. Le Blanc, E.: Respiratorischer Gasaustausch und Lungendurchblutung unter normalen und krankhaften Zuständen der Atmungsorgane. Untersuchungen am arteriellen und venösen Blut von Mensch und Tier , Beitr. z. Klin. d. Tuberk. 1:21, 1922.Crossref 9. Andrus, W. DeW.: Observations on the Cardiorespiratory Physiology Following the Collapse of One Lung by Bronchial Ligation , Arch. Surg. 10:506 ( (Jan.) ) 1925.Crossref 10. Coryllos, P. N., and Birnbaum, G. L.: The Circulation in the Compressed, Atelectatic and Pneumonic Lung (Pneumothorax-Apneumatosis-Pneumonia) , Arch. Surg. 19:1346 ( (Jan.) ) 1929.Crossref 11. Bruns, O.: Die Blutzirkulation in atmenden und atelektatischen Lungen , Deutsche med. Wchnschr. 39:101, 1913.Crossref 12. Bruns' experiments are described in the section on "Lung Collapsed by Closed Pneumothorax," p. 231, this issue. 13. Bruns, O.: Ueber die Blutzirkulation in der atelektatischen Lunge , Deutsches Arch. f. klin. Med. 108:469, 1912. 14. Bruns (footnotes 11 and 13). 15. Cloetta, M.: In welcher Respirationsphase ist die Lunge am besten durchblutet? Arch. f. exper. Path. u. Pharmakol. 70:407, 1912.Crossref 16. White, W. C., and Gammon, A. M.: Some New Features of Interest about the Pulmonary Circulation and the Fate therein of Intravenously Introduced Fats , Tr. Nat. A. Prev. Tuberc., Tenth Annual Meeting , 1914, pp. 215-220. 17. Brauer, L.: Ueber die operative Behandlung der Lungentuberkulose , Deutsche med. Wchnschr. 47:548, 1921.Crossref 18. Dock, W., and Harrison, T. R.: The Blood Flow Through the Lungs in Experimental Pneumothorax , Am. Rev. Tuberc. 10:534, 1925. 19. Weiss, R.: Ueber die Durchblutung der Kollapslunge beim experimentellen Pneumothorax , Ztschr. f. d. ges. exper. Med. 53:138, 1926.Crossref 20. Lilienthal, H.: Thoracic Surgery , Philadelphia, W. B. Saunders Company, 1926, vol. 2, p. 325. 21. Andrus, W. DeW., and Wilson, J. D.: The Effects of Closed Pneumothorax and Phrenicotomy on the Cardiorespiratory Function , Arch. Surg. 19:1205 ( (Dec.) ) 1929.Crossref 22. Sackur: Zur Lehre vom Pneumothorax , Ztschr. f. klin. Med. 29:25, 1896 23. Weiteres zur Lehre vom Pneumothorax , Virchows Arch. f. path. Anat. 150:151, 1897.Crossref 24. Sauerbruch, F.: Zur Pathologie des offenen Pneumothorax und die Grundlagen meines Verfahrens zu seiner Ausschaltung , Mitt. a. d. Grenzgeb. d. Med. u. Chir. 13:399, 1904. 25. Bruns (footnotes 2 and 13). 26. Yates, J. L.: Rationale of Operations Helpful in Promoting Recoveries from Pulmonary Tuberculosis , Arch. Surg. 14:369 ( (Jan.) ) 1927Crossref 27. in discussion of papers on " Acute and Chronic Nontuberculous Bronchopulmonary Suppurative Lesions ," Arch. Surg. 16:312 ( (Jan.) ) 1928. 28. Yates (footnote 25, second reference). 29. Meyer, W. (footnote 25, second reference, p. 309). 30. Torek, F. (footnote 25, second reference, pp. 316-317). 31. Eggers, C., and Kernan, J. D.: Acute Pulmonary Suppuration: Selective Action of Artificial Pneumothorax in the Treatment of this Disease , Arch. Surg. 16:279 ( (Jan.) ) 1928.Crossref 32. Churchill, E. D., and Agassiz, A.: A Method for Separating the Air Breathed by the Right and Left Lungs, together with the Effect of Pulmonary Circulatory Changes on this Divided Breathing , Am. J. Physiol. 76:6, 1926. 33. Moore, R. L.: A Study of the Hering-Breuer Reflex , J. Exper. Med. 46:819, 1927.Crossref 34. Stewart, H. J.: The Oxygen and Carbon Dioxide Contents of the Arterial and Mixed Venous Blood in Normal Intact Dogs , J. Biol. Chem. 62:641, 1925. 35. Van Slyke, D. D., and Neill, J. M.: The Determination of Gases in Blood and Other Solutions by Vacuum Extraction and Manometric Measurement , J. Biol. Chem. 61:523, 1924. 36. Fick, A.: Ueber die Messung des Blutquantums in der Herzventrikeln , Verhandl. d. phys.-med. Gesellsch. 2:16, 1870. 37. Moore, R. L., and Harrison, T. R.: Unpublished experiments. 38. Lichtheim, L.: Versuche über Lungenatelektase , Arch. f. exper. Path. u. Pharmakol. 10:54, 1878.Crossref 39. Schlaepfer, K.: The Effect of the Ligation of the Pulmonary Artery of One Lung without and with Resection of the Phrenic Nerve , Arch. Surg. 13:623 ( (Nov.) ) 1926.Crossref 40. Moore, R. L.: Unpublished experiments. 41. Moore (footnote 31, fig. 2, p. 827). http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

THE VOLUME OF BLOOD FLOW PER MINUTE THROUGH THE LUNGS FOLLOWING COLLAPSE OF ONE LUNG BY OCCLUSION OF ITS BRONCHUS: EXPERIMENTAL OBSERVATIONS

Archives of Surgery , Volume 22 (2) – Feb 1, 1931

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American Medical Association
Copyright
Copyright © 1931 American Medical Association. All Rights Reserved.
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0004-0010
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1538-3644
DOI
10.1001/archsurg.1931.01160020048003
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Abstract

Abstract The effect of atelectasis1 of a lung on the pulmonary blood circulation became particularly interesting with the introduction of pneumothorax in the treatment for certain types of pulmonary tuberculosis. The significance of this relationship has increased in importance with the development of thoracic surgery, because there are few, if any, surgical procedures within the thoracic cavity or involving the thoracic wall that do not affect the expansion of the lungs. In spite of many experimental studies, however, there is no uniform agreement as to the exact nature of the resulting circulatory changes. Different investigators have arrived at conclusions that are diametrically opposed to each other, and the present status of knowledge is at best confusing and nonconvincing. The contradictory results are in part due to the fact that so far it has not been possible to determine by direct measurement the amount of blood that passes through a lung. References 1. Coryllos and Birnbaum ( Obstructive Massive Atelectasis of the Lung ; Arch. Surg. 16:501 [ (Jan.) ] 1928)Crossref 2. Bruns, O.: Untersuchungen über den respiratorischen Gaswechsel bei Erkrankungen der Lunge und der luftzuführenden Wege , Deutsches Arch. f. klin. Med. 107:468, 1912. 3. Graham, E. A., and Bell, R. D.: Open Pneumothorax: Its Relation to the Treatment of Empyema , Am. J. M. Sc. 156:839, 1918.Crossref 4. Loewy, A., and von Schrötter, H.: Untersuchungen über die Blutcirkulation beim Menschen , Ztschr. f. exper. Path. u. Therap. 1:197, 1905.Crossref 5. Hess, R.: Ueber die Durchblutung nicht atmender Lungengebiete , Deutsches Arch. f. klin. Med. 106:478, 1912. 6. In this calculation the oxygen content of the blood from the breathing lung (right lung) is assumed to be the same as the control arterial oxygen content. The formula from which the calculation is made is given in the paragraph which describes the experiments of Weiss. 7. Adams, D. K., and Morris, N.: Anoxaemia and the Administration of Oxygen , J. Physiol. (Proc. Physiol. Soc.) 54:102-104; 106-107, 1921. 8. Le Blanc, E.: Respiratorischer Gasaustausch und Lungendurchblutung unter normalen und krankhaften Zuständen der Atmungsorgane. Untersuchungen am arteriellen und venösen Blut von Mensch und Tier , Beitr. z. Klin. d. Tuberk. 1:21, 1922.Crossref 9. Andrus, W. DeW.: Observations on the Cardiorespiratory Physiology Following the Collapse of One Lung by Bronchial Ligation , Arch. Surg. 10:506 ( (Jan.) ) 1925.Crossref 10. Coryllos, P. N., and Birnbaum, G. L.: The Circulation in the Compressed, Atelectatic and Pneumonic Lung (Pneumothorax-Apneumatosis-Pneumonia) , Arch. Surg. 19:1346 ( (Jan.) ) 1929.Crossref 11. Bruns, O.: Die Blutzirkulation in atmenden und atelektatischen Lungen , Deutsche med. Wchnschr. 39:101, 1913.Crossref 12. Bruns' experiments are described in the section on "Lung Collapsed by Closed Pneumothorax," p. 231, this issue. 13. Bruns, O.: Ueber die Blutzirkulation in der atelektatischen Lunge , Deutsches Arch. f. klin. Med. 108:469, 1912. 14. Bruns (footnotes 11 and 13). 15. Cloetta, M.: In welcher Respirationsphase ist die Lunge am besten durchblutet? Arch. f. exper. Path. u. Pharmakol. 70:407, 1912.Crossref 16. White, W. C., and Gammon, A. M.: Some New Features of Interest about the Pulmonary Circulation and the Fate therein of Intravenously Introduced Fats , Tr. Nat. A. Prev. Tuberc., Tenth Annual Meeting , 1914, pp. 215-220. 17. Brauer, L.: Ueber die operative Behandlung der Lungentuberkulose , Deutsche med. Wchnschr. 47:548, 1921.Crossref 18. Dock, W., and Harrison, T. R.: The Blood Flow Through the Lungs in Experimental Pneumothorax , Am. Rev. Tuberc. 10:534, 1925. 19. Weiss, R.: Ueber die Durchblutung der Kollapslunge beim experimentellen Pneumothorax , Ztschr. f. d. ges. exper. Med. 53:138, 1926.Crossref 20. Lilienthal, H.: Thoracic Surgery , Philadelphia, W. B. Saunders Company, 1926, vol. 2, p. 325. 21. Andrus, W. DeW., and Wilson, J. D.: The Effects of Closed Pneumothorax and Phrenicotomy on the Cardiorespiratory Function , Arch. Surg. 19:1205 ( (Dec.) ) 1929.Crossref 22. Sackur: Zur Lehre vom Pneumothorax , Ztschr. f. klin. Med. 29:25, 1896 23. Weiteres zur Lehre vom Pneumothorax , Virchows Arch. f. path. Anat. 150:151, 1897.Crossref 24. Sauerbruch, F.: Zur Pathologie des offenen Pneumothorax und die Grundlagen meines Verfahrens zu seiner Ausschaltung , Mitt. a. d. Grenzgeb. d. Med. u. Chir. 13:399, 1904. 25. Bruns (footnotes 2 and 13). 26. Yates, J. L.: Rationale of Operations Helpful in Promoting Recoveries from Pulmonary Tuberculosis , Arch. Surg. 14:369 ( (Jan.) ) 1927Crossref 27. in discussion of papers on " Acute and Chronic Nontuberculous Bronchopulmonary Suppurative Lesions ," Arch. Surg. 16:312 ( (Jan.) ) 1928. 28. Yates (footnote 25, second reference). 29. Meyer, W. (footnote 25, second reference, p. 309). 30. Torek, F. (footnote 25, second reference, pp. 316-317). 31. Eggers, C., and Kernan, J. D.: Acute Pulmonary Suppuration: Selective Action of Artificial Pneumothorax in the Treatment of this Disease , Arch. Surg. 16:279 ( (Jan.) ) 1928.Crossref 32. Churchill, E. D., and Agassiz, A.: A Method for Separating the Air Breathed by the Right and Left Lungs, together with the Effect of Pulmonary Circulatory Changes on this Divided Breathing , Am. J. Physiol. 76:6, 1926. 33. Moore, R. L.: A Study of the Hering-Breuer Reflex , J. Exper. Med. 46:819, 1927.Crossref 34. Stewart, H. J.: The Oxygen and Carbon Dioxide Contents of the Arterial and Mixed Venous Blood in Normal Intact Dogs , J. Biol. Chem. 62:641, 1925. 35. Van Slyke, D. D., and Neill, J. M.: The Determination of Gases in Blood and Other Solutions by Vacuum Extraction and Manometric Measurement , J. Biol. Chem. 61:523, 1924. 36. Fick, A.: Ueber die Messung des Blutquantums in der Herzventrikeln , Verhandl. d. phys.-med. Gesellsch. 2:16, 1870. 37. Moore, R. L., and Harrison, T. R.: Unpublished experiments. 38. Lichtheim, L.: Versuche über Lungenatelektase , Arch. f. exper. Path. u. Pharmakol. 10:54, 1878.Crossref 39. Schlaepfer, K.: The Effect of the Ligation of the Pulmonary Artery of One Lung without and with Resection of the Phrenic Nerve , Arch. Surg. 13:623 ( (Nov.) ) 1926.Crossref 40. Moore, R. L.: Unpublished experiments. 41. Moore (footnote 31, fig. 2, p. 827).

Journal

Archives of SurgeryAmerican Medical Association

Published: Feb 1, 1931

References