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The Value of Systemic Hemostatic Drugs: A Double Blind Evaluation of Agents Used to Increase Coagulation During Tonsillectomy and Adenoidectomy

The Value of Systemic Hemostatic Drugs: A Double Blind Evaluation of Agents Used to Increase... Abstract Drugs presumed to increase the coagulation of blood or to increase the strength of capillaries are frequently used prior to tonsillectomy or adenoidectomy without indictation that the patient requires or, indeed, benefits from them. The interpretation of results obtained from these agents is necessarily based upon subjective evaluation, since accurate measurement of bleeding during the operative procedure is difficult. The physician tends to be influenced in subjective evaluations by his conception of the anticipated results; no results have been found of a "blind trial" of coagulant agents, in which the surgeon was unaware of whether the drug to be tested or a placebo had been given. The present report concerns such a "blind trial" of three agents commonly employed to reduce bleeding during tonsillectomy and adenoidectomy. The agents evaluated were (1) a combination of oxalic and malonic acids (Koagamin), (2) adrenochrome monosemicarbazide (Adrenosem) and (3) intravenous estrogens (Premarin). Oxalic and References 1. Sherber, D. A.: The Control of Bleeding , Am. J. Surg. 86:331, 1953.Crossref 2. Peele, J. C.: Adrenosem in the Control of Hemorrhage from the Nose and Throat , A. M. A. Arch. Otolaryng. 61:450, 1955.Crossref 3. Perkins, R. E. L.: A Clinical Investigation of Adrenochrome Monosemicarbazone Sodium Salicylate , Oral Surg. 10:230, 1957.Crossref 4. Blain, A. W., and Campbell, K. N.: Hemostatic Effect of Oxalic Acid , Arch. Surg. 44:1117, 1942.Crossref 5. Steinberg, A., and Brown, W. R.: A New Concept Regarding the Mechanism of Clotting and the Control of Hemorrhage , Am. J. Physiol. 126:638, 1939. 6. Johnson, J. F.: Changes in Plasma Prothrombin, Ac-Globulin, and Antithrombin Concentration Following Intravenous Administration of Estrogens , Proc. Soc. Exper. Biol. & Med. 94:92, 1957. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Otolaryngology American Medical Association

The Value of Systemic Hemostatic Drugs: A Double Blind Evaluation of Agents Used to Increase Coagulation During Tonsillectomy and Adenoidectomy

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References (7)

Publisher
American Medical Association
Copyright
Copyright © 1959 American Medical Association. All Rights Reserved.
ISSN
0096-6894
DOI
10.1001/archotol.1959.00730040076013
Publisher site
See Article on Publisher Site

Abstract

Abstract Drugs presumed to increase the coagulation of blood or to increase the strength of capillaries are frequently used prior to tonsillectomy or adenoidectomy without indictation that the patient requires or, indeed, benefits from them. The interpretation of results obtained from these agents is necessarily based upon subjective evaluation, since accurate measurement of bleeding during the operative procedure is difficult. The physician tends to be influenced in subjective evaluations by his conception of the anticipated results; no results have been found of a "blind trial" of coagulant agents, in which the surgeon was unaware of whether the drug to be tested or a placebo had been given. The present report concerns such a "blind trial" of three agents commonly employed to reduce bleeding during tonsillectomy and adenoidectomy. The agents evaluated were (1) a combination of oxalic and malonic acids (Koagamin), (2) adrenochrome monosemicarbazide (Adrenosem) and (3) intravenous estrogens (Premarin). Oxalic and References 1. Sherber, D. A.: The Control of Bleeding , Am. J. Surg. 86:331, 1953.Crossref 2. Peele, J. C.: Adrenosem in the Control of Hemorrhage from the Nose and Throat , A. M. A. Arch. Otolaryng. 61:450, 1955.Crossref 3. Perkins, R. E. L.: A Clinical Investigation of Adrenochrome Monosemicarbazone Sodium Salicylate , Oral Surg. 10:230, 1957.Crossref 4. Blain, A. W., and Campbell, K. N.: Hemostatic Effect of Oxalic Acid , Arch. Surg. 44:1117, 1942.Crossref 5. Steinberg, A., and Brown, W. R.: A New Concept Regarding the Mechanism of Clotting and the Control of Hemorrhage , Am. J. Physiol. 126:638, 1939. 6. Johnson, J. F.: Changes in Plasma Prothrombin, Ac-Globulin, and Antithrombin Concentration Following Intravenous Administration of Estrogens , Proc. Soc. Exper. Biol. & Med. 94:92, 1957.

Journal

A.M.A. Archives of Otolaryngology – American Medical Association

Published: Jul 1, 1959

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