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The Ultrastructure of Descemet's Membrane: III. Fuchs' Dystrophy

The Ultrastructure of Descemet's Membrane: III. Fuchs' Dystrophy Abstract • The ultrastructure of Descemet's membrane was studied by transmission electron microscopy in corneal buttons removed from 11 phakic eyes with Fuchs' dystrophy. Abnormalities in Descemet's membrane consistent with abnormal endothelial function early in life (prior to age 20 years) were present in all corneas. Thus, despite the relatively late clinical onset of Fuchs' dystrophy, endothelial abnormalities are present quite early in life in this disease. An abnormal fibrillar layer was thicker in those corneas with greater stromal and epithelial edema, possibly indicating that this layer is formed mainly during periods of endothelial decompensation. References 1. Fuchs E: Dystrophia epithelialis Corneae . Albrecht Von Graefes Arch Klin Exp Ophthalmol 1910;76:478-508.Crossref 2. Kraupa E: Pigmentierung der hornhauthinterfläche bei 'Dystrophia epithelialis (Fuchs).' Z Augenheilkd 1920;44:247-250. 3. Vogt A: Über keratitis bullosa bei cornea guttata . Z Augenheilkd 1929;69:262-263. 4. Stocker FW: The endothelium of the cornea and its clinical implications . Trans Am Ophthalmol Soc 1953;51:669-786. 5. Kayes J, Holmberg A: The fine structure of the cornea in Fuchs' endothelial dystrophy . Invest Ophthalmol Vis Sci 1964;3:47-67. 6. Iwamoto T, DeVoe G: Electron microscopic studies on Fuchs' combined dystrophy: I. Posterior portion of the cornea . Invest Ophthalmol Vis Sci 1971;10:9-28. 7. Pouliquen Y, Graf B, Offret G: Étude histologique et ultrastructurale de la cornée dans une dystrophie endo-épithéliale de Fuchs (cornea guttata) . Arch Ophthalmol 1971;31:427-444. 8. Hogan MJ, Wood I, Fine M: Fuchs' endothelial dystrophy of the cornea . Am J Ophthalmol 1974;78:363-383. 9. Polack FM: The posterior corneal surface in Fuchs' dystrophy: Scanning electron microscopic study . Invest Ophthalmol Vis Sci 1974;13:913-922. 10. Waring GO, Laibson PR, Rodrigues M: Clinical and pathologic alterations of Descemet's membrane: With emphasis on endothelial metaplasia . Surv Ophthalmol 1974;18:325-368. 11. Krachmer JH, Purcell JJ, Young CW, et al: Corneal endothelial dystrophy: A study of 64 families . Arch Ophthalmol 1978;96:2036-2039.Crossref 12. Mishima S, Hedbys BO: Measurement of corneal thickness with the Haag-Streit pachometer . Arch Ophthalmol 1968;80:710-713.Crossref 13. Burns RR, Bourne WM, Brubaker RF: Endothelial function in patients with cornea guttata . Invest Ophthalmol Vis Sci 1981;20:77-85. 14. Waring GO: Posterior collagenous layer (PCL) of the cornea . Arch Ophthalmol 1982;100:122-134.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

The Ultrastructure of Descemet's Membrane: III. Fuchs' Dystrophy

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Publisher
American Medical Association
Copyright
Copyright © 1982 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1982.01030040932013
Publisher site
See Article on Publisher Site

Abstract

Abstract • The ultrastructure of Descemet's membrane was studied by transmission electron microscopy in corneal buttons removed from 11 phakic eyes with Fuchs' dystrophy. Abnormalities in Descemet's membrane consistent with abnormal endothelial function early in life (prior to age 20 years) were present in all corneas. Thus, despite the relatively late clinical onset of Fuchs' dystrophy, endothelial abnormalities are present quite early in life in this disease. An abnormal fibrillar layer was thicker in those corneas with greater stromal and epithelial edema, possibly indicating that this layer is formed mainly during periods of endothelial decompensation. References 1. Fuchs E: Dystrophia epithelialis Corneae . Albrecht Von Graefes Arch Klin Exp Ophthalmol 1910;76:478-508.Crossref 2. Kraupa E: Pigmentierung der hornhauthinterfläche bei 'Dystrophia epithelialis (Fuchs).' Z Augenheilkd 1920;44:247-250. 3. Vogt A: Über keratitis bullosa bei cornea guttata . Z Augenheilkd 1929;69:262-263. 4. Stocker FW: The endothelium of the cornea and its clinical implications . Trans Am Ophthalmol Soc 1953;51:669-786. 5. Kayes J, Holmberg A: The fine structure of the cornea in Fuchs' endothelial dystrophy . Invest Ophthalmol Vis Sci 1964;3:47-67. 6. Iwamoto T, DeVoe G: Electron microscopic studies on Fuchs' combined dystrophy: I. Posterior portion of the cornea . Invest Ophthalmol Vis Sci 1971;10:9-28. 7. Pouliquen Y, Graf B, Offret G: Étude histologique et ultrastructurale de la cornée dans une dystrophie endo-épithéliale de Fuchs (cornea guttata) . Arch Ophthalmol 1971;31:427-444. 8. Hogan MJ, Wood I, Fine M: Fuchs' endothelial dystrophy of the cornea . Am J Ophthalmol 1974;78:363-383. 9. Polack FM: The posterior corneal surface in Fuchs' dystrophy: Scanning electron microscopic study . Invest Ophthalmol Vis Sci 1974;13:913-922. 10. Waring GO, Laibson PR, Rodrigues M: Clinical and pathologic alterations of Descemet's membrane: With emphasis on endothelial metaplasia . Surv Ophthalmol 1974;18:325-368. 11. Krachmer JH, Purcell JJ, Young CW, et al: Corneal endothelial dystrophy: A study of 64 families . Arch Ophthalmol 1978;96:2036-2039.Crossref 12. Mishima S, Hedbys BO: Measurement of corneal thickness with the Haag-Streit pachometer . Arch Ophthalmol 1968;80:710-713.Crossref 13. Burns RR, Bourne WM, Brubaker RF: Endothelial function in patients with cornea guttata . Invest Ophthalmol Vis Sci 1981;20:77-85. 14. Waring GO: Posterior collagenous layer (PCL) of the cornea . Arch Ophthalmol 1982;100:122-134.Crossref

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Dec 1, 1982

References