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The Treatment of Vitiligo with Psoralen Derivatives

The Treatment of Vitiligo with Psoralen Derivatives Abstract During the past three years 123 patients with vitiligo have been treated with psoralen derivatives in the Dermatology Clinic, Christian Medical College Hospital, Vellore, South India. Because vitiligo is particularly disfiguring in an Indian patient, it often gives rise to severe psychological strain as well as to social stigma. In this area it is frequently confused in the public mind with leprosy, as the Tamil word for this condition is literally translated as "white leprosy." History Native practitioners in India have used oils of various plants in the treatment of vitiligo for centuries. An old Ayuruedic treatment consists of a purgative of figs, kine, cherry, and dill mixed with concentrated cane sugar juice. This is followed by local application of a mixture of Psoralea semina seeds (Bouchi), radish seeds, and cow's urine and exposure to sunlight up to tolerance of the patient.1 Panja and Maple-stone reported the References 1. Caraka Samahita , Vol. 3, Jamnagar, India, Shri Gulab Kunverba Ayurvedic Society. 2. Panja, D. and Maplestone, P. A.: A New Method of Treating Leucoderma , Indian M. Gaz. 75:93, 1940. 3. Fahmy, I. R., and Abu-Shady, H.: The Isolation and Properties of Ammoidin, Ammidin and Majudin and Their Effect in the Treatment of Leukodermia , Quart. J. Pharm. & Pharmacol. 21:499, 1948. 4. Cohen, M. H.: Successful Treatment of Vitiligo , Arch. Dermat. & Syph. 28:215, 1933. 5. Mukergee, B.: Personal communication to the author. 6. Carvalho, A. A.: A Few Observations on Leucoderma and a New Method of Treatment , J. Indian M. A. 26:93, 1956. 7. Cochrane, R. G.: A Practical Textbook of Leprosy , New York, Oxford University Press, 1947. 8. Sidi, E., and Bourgeois-Gavardin, J.: The Treatment of Vitiligo with ``Ammi Majus,'' Presse méd. 61:436,1953. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Dermatology American Medical Association

The Treatment of Vitiligo with Psoralen Derivatives

A.M.A. Archives of Dermatology , Volume 78 (5) – Nov 1, 1958

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Publisher
American Medical Association
Copyright
Copyright © 1958 American Medical Association. All Rights Reserved.
ISSN
0096-5359
DOI
10.1001/archderm.1958.01560110043006
Publisher site
See Article on Publisher Site

Abstract

Abstract During the past three years 123 patients with vitiligo have been treated with psoralen derivatives in the Dermatology Clinic, Christian Medical College Hospital, Vellore, South India. Because vitiligo is particularly disfiguring in an Indian patient, it often gives rise to severe psychological strain as well as to social stigma. In this area it is frequently confused in the public mind with leprosy, as the Tamil word for this condition is literally translated as "white leprosy." History Native practitioners in India have used oils of various plants in the treatment of vitiligo for centuries. An old Ayuruedic treatment consists of a purgative of figs, kine, cherry, and dill mixed with concentrated cane sugar juice. This is followed by local application of a mixture of Psoralea semina seeds (Bouchi), radish seeds, and cow's urine and exposure to sunlight up to tolerance of the patient.1 Panja and Maple-stone reported the References 1. Caraka Samahita , Vol. 3, Jamnagar, India, Shri Gulab Kunverba Ayurvedic Society. 2. Panja, D. and Maplestone, P. A.: A New Method of Treating Leucoderma , Indian M. Gaz. 75:93, 1940. 3. Fahmy, I. R., and Abu-Shady, H.: The Isolation and Properties of Ammoidin, Ammidin and Majudin and Their Effect in the Treatment of Leukodermia , Quart. J. Pharm. & Pharmacol. 21:499, 1948. 4. Cohen, M. H.: Successful Treatment of Vitiligo , Arch. Dermat. & Syph. 28:215, 1933. 5. Mukergee, B.: Personal communication to the author. 6. Carvalho, A. A.: A Few Observations on Leucoderma and a New Method of Treatment , J. Indian M. A. 26:93, 1956. 7. Cochrane, R. G.: A Practical Textbook of Leprosy , New York, Oxford University Press, 1947. 8. Sidi, E., and Bourgeois-Gavardin, J.: The Treatment of Vitiligo with ``Ammi Majus,'' Presse méd. 61:436,1953.

Journal

A.M.A. Archives of DermatologyAmerican Medical Association

Published: Nov 1, 1958

References