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The Treatment of North American Blastomycosis with Amphotericin B

The Treatment of North American Blastomycosis with Amphotericin B Abstract The many reports in the medical literature on the treatment of North American blastomycosis with the aromatic diamidines attest to the beneficial effect obtained by the use of these compounds in this specific fungus infection.1-13 There is increasing evidence, however, that stilbamidine and 2-hydroxystilbamidine are not effective in curing all instances of the systemic type of North American blastomycosis.9,14,15 This systemic form of the disease, which was usually fatal16 prior to the use of the aromatic diamidines, has been beneficially influenced by this therapy, but often not cured. The relapses which have occurred following the proper administration of the stilbenes would appear to have developed in that group of patients exhibiting the immunological status comprising a negative blastomycin skin test and a persistently positive complement-fixation test, a type of blastomycosis which Smith17 has categorized as having the poorest prognosis. Relapse following stilbamidine References 1. Amphotericin B was supplied through the courtesy of Galvin Hildick-Smith, M.D., Associate Medical Director, The Squibb Institute for Medical Research, New Brunswick, N. J. 2. U. S. Veterans Administration Hospital, Ann Arbor, Mich. 3. Schoenbach, E. B.; Miller, J. M.; Ginsberg, M., and Long, P. H.: Systemic Blastomycosis Treated with Stilbamidine , J. A. M. A. 146:1317 ( (Aug. 4) ) 1951.Crossref 4. Schoenbach, E. B.; Miller, J. M., and Long, P.: The Treatment of Systemic Blastomycosis with Stilbamidine , Ann. Int. Med. 37:31 ( (July) ) 1952.Crossref 5. Curtis, A. C., and Harrell, E. R.: Use of Two Stilbene Derivatives (Diethylstilbestrol and Stilbamidine) in Treatment of Blastomycosis , A. M. A. Arch. Dermat. & Syph. 66:676 ( (Dec.) ) 1952. 6. Fink, J. C.; Vander Ploeg, D. E., and Moursund, M. P.: "Stilbamidine" in the Treatment of Cutaneous Blastomycosis: Report of a Case , J. A. M. A. 151:1395 ( (April 18) ) 1953. 7. Smith, D. T.: Stilbamidine Therapy for Blastomycosis , G. P. 8:69 ( (July) ) 1953. 8. Marshak, L. C.: Cutaneous Blastomycosis Treated with 4,4′-Stilbenedicarboxyamidine (Stilbamidine) , A. M. A. Arch. Dermat. & Syph. 68:94 ( (July) ) 1953. 9. Rodriguez, J.: Stilbamidine (4,4′-Stilbenedicarboxyamidine) Therapy in Blastomycosis , A. M. A. Arch. Dermat. & Syph. 68:95 ( (July) ) 1953. 10. Slaughter, J. C., Jr.: Stilbamidine in Treatment of Widely Disseminated Blastomycosis (with Two-Year Follow-Up) , A. M. A. Arch. Dermat. & Syph. 70:663 ( (Nov.) ) 1954. 11. Harrell, E. R.; Bocobo, F. C.; Curtis, A. C., A Study of North American Blastomycosis and Its Treatment with Stilbamidine and 2-Hydroxystilbamidine , Ann. Int. Med. 43:1076 ( (Nov.) ) 1955. 12. Weinberg, B. J.; Lawrence, C. H., and Bucholz, A.: Systemic Blastomycosis Treated with 2-Hydroxystilbamidine , A. M. A. Arch. of Int. Med. 94:493 ( (Sept.) ) 1954. 13. Smith, J. G., Jr.; Harris, J. S.; Conant, N. F., and Smith, D. T.: An Epidemic of North American Blastomycosis , J. A. M. A. 158:641 ( (June 25) ) 1955. 14. Colsky, J.: Treatment of Systemic Blastomycosis with 2-Hydroxystilbamidine , A. M. A. Arch. Int. Med. 93:796 ( (May) ) 1954. 15. London, I. D.: Hydroxystilbamidine Treatment of North American Blastomycosis , South. M. J. 49:1098 ( (Oct.) ) 1956. 16. Sivok, G. C. and Lich, R., Jr.: Blastomycosis Treated by Stilbamidine with Relapse , J. Urol. 76:678 ( (Nov.) ) 1956. 17. Kuhn, B. H.: Stilbamidine-Resistant North American Blastomycosis: Blastomyces Vaccine Treatment , A. M. A. Arch. Dermat. 73:556 ( (June) ) 1956. 18. Martin, D. S., and Smith, D. T.: Blastomycosis (American Blastomycosis, Gilchrist's Disease): I. Review of Literature , Am. Rev. Tuberc. 39:275 ( (March) ) 1939 19. II. Report of 13 New Cases , Am. Rev. Tuberc. 39:488 ( (April) ) 1939. 20. Smith, D. T.: Immunologic Types of Blastomycosis , A. M. A. Arch. Int. Med. 31:463 ( (Sept.) ) 1949. 21. Summary of Information for Clinical Investigators, Squibb Amphotericin , The Squibb Institute for Medical Research, New Brunswick, N. J., E. R. Squibb & Sons, (Oct. 28) , 1955. 22. Fiese, M. J.: Treatment of Disseminated Coccidioidomycosis with Amphotericin B: Report of a Case , California Med. 86:119 ( (Feb.) ) 1957. 23. Bocobo, F. C.; Curtis, A. C., and Harrell, E. R.: In Vitro Fungistatic Activity of Stilbamidine, Propamidine, Pentamidine, and Diethylstilbesterol , J. Invest. Dermat. 21:149 ( (Sept.) ) 1953. 24. Schwarz, J., and Baum, G. L.: Blastomycosis , Am. J. Clin. Path. 21:999 ( (Nov.) ) 1951. 25. Wilson, J. W.; Cawley, E. P.; Weidman, F. D., and Gilmer, W. S.: Prmiary Cutaneous North American Blastomycosis , A. M. A. Arch. Dermat. 71:39 ( (Jan.) ) 1955.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Dermatology American Medical Association

The Treatment of North American Blastomycosis with Amphotericin B

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Publisher
American Medical Association
Copyright
Copyright © 1957 American Medical Association. All Rights Reserved.
ISSN
0096-5359
DOI
10.1001/archderm.1957.01550230025004
Publisher site
See Article on Publisher Site

Abstract

Abstract The many reports in the medical literature on the treatment of North American blastomycosis with the aromatic diamidines attest to the beneficial effect obtained by the use of these compounds in this specific fungus infection.1-13 There is increasing evidence, however, that stilbamidine and 2-hydroxystilbamidine are not effective in curing all instances of the systemic type of North American blastomycosis.9,14,15 This systemic form of the disease, which was usually fatal16 prior to the use of the aromatic diamidines, has been beneficially influenced by this therapy, but often not cured. The relapses which have occurred following the proper administration of the stilbenes would appear to have developed in that group of patients exhibiting the immunological status comprising a negative blastomycin skin test and a persistently positive complement-fixation test, a type of blastomycosis which Smith17 has categorized as having the poorest prognosis. Relapse following stilbamidine References 1. Amphotericin B was supplied through the courtesy of Galvin Hildick-Smith, M.D., Associate Medical Director, The Squibb Institute for Medical Research, New Brunswick, N. J. 2. U. S. Veterans Administration Hospital, Ann Arbor, Mich. 3. Schoenbach, E. B.; Miller, J. M.; Ginsberg, M., and Long, P. H.: Systemic Blastomycosis Treated with Stilbamidine , J. A. M. A. 146:1317 ( (Aug. 4) ) 1951.Crossref 4. Schoenbach, E. B.; Miller, J. M., and Long, P.: The Treatment of Systemic Blastomycosis with Stilbamidine , Ann. Int. Med. 37:31 ( (July) ) 1952.Crossref 5. Curtis, A. C., and Harrell, E. R.: Use of Two Stilbene Derivatives (Diethylstilbestrol and Stilbamidine) in Treatment of Blastomycosis , A. M. A. Arch. Dermat. & Syph. 66:676 ( (Dec.) ) 1952. 6. Fink, J. C.; Vander Ploeg, D. E., and Moursund, M. P.: "Stilbamidine" in the Treatment of Cutaneous Blastomycosis: Report of a Case , J. A. M. A. 151:1395 ( (April 18) ) 1953. 7. Smith, D. T.: Stilbamidine Therapy for Blastomycosis , G. P. 8:69 ( (July) ) 1953. 8. Marshak, L. C.: Cutaneous Blastomycosis Treated with 4,4′-Stilbenedicarboxyamidine (Stilbamidine) , A. M. A. Arch. Dermat. & Syph. 68:94 ( (July) ) 1953. 9. Rodriguez, J.: Stilbamidine (4,4′-Stilbenedicarboxyamidine) Therapy in Blastomycosis , A. M. A. Arch. Dermat. & Syph. 68:95 ( (July) ) 1953. 10. Slaughter, J. C., Jr.: Stilbamidine in Treatment of Widely Disseminated Blastomycosis (with Two-Year Follow-Up) , A. M. A. Arch. Dermat. & Syph. 70:663 ( (Nov.) ) 1954. 11. Harrell, E. R.; Bocobo, F. C.; Curtis, A. C., A Study of North American Blastomycosis and Its Treatment with Stilbamidine and 2-Hydroxystilbamidine , Ann. Int. Med. 43:1076 ( (Nov.) ) 1955. 12. Weinberg, B. J.; Lawrence, C. H., and Bucholz, A.: Systemic Blastomycosis Treated with 2-Hydroxystilbamidine , A. M. A. Arch. of Int. Med. 94:493 ( (Sept.) ) 1954. 13. Smith, J. G., Jr.; Harris, J. S.; Conant, N. F., and Smith, D. T.: An Epidemic of North American Blastomycosis , J. A. M. A. 158:641 ( (June 25) ) 1955. 14. Colsky, J.: Treatment of Systemic Blastomycosis with 2-Hydroxystilbamidine , A. M. A. Arch. Int. Med. 93:796 ( (May) ) 1954. 15. London, I. D.: Hydroxystilbamidine Treatment of North American Blastomycosis , South. M. J. 49:1098 ( (Oct.) ) 1956. 16. Sivok, G. C. and Lich, R., Jr.: Blastomycosis Treated by Stilbamidine with Relapse , J. Urol. 76:678 ( (Nov.) ) 1956. 17. Kuhn, B. H.: Stilbamidine-Resistant North American Blastomycosis: Blastomyces Vaccine Treatment , A. M. A. Arch. Dermat. 73:556 ( (June) ) 1956. 18. Martin, D. S., and Smith, D. T.: Blastomycosis (American Blastomycosis, Gilchrist's Disease): I. Review of Literature , Am. Rev. Tuberc. 39:275 ( (March) ) 1939 19. II. Report of 13 New Cases , Am. Rev. Tuberc. 39:488 ( (April) ) 1939. 20. Smith, D. T.: Immunologic Types of Blastomycosis , A. M. A. Arch. Int. Med. 31:463 ( (Sept.) ) 1949. 21. Summary of Information for Clinical Investigators, Squibb Amphotericin , The Squibb Institute for Medical Research, New Brunswick, N. J., E. R. Squibb & Sons, (Oct. 28) , 1955. 22. Fiese, M. J.: Treatment of Disseminated Coccidioidomycosis with Amphotericin B: Report of a Case , California Med. 86:119 ( (Feb.) ) 1957. 23. Bocobo, F. C.; Curtis, A. C., and Harrell, E. R.: In Vitro Fungistatic Activity of Stilbamidine, Propamidine, Pentamidine, and Diethylstilbesterol , J. Invest. Dermat. 21:149 ( (Sept.) ) 1953. 24. Schwarz, J., and Baum, G. L.: Blastomycosis , Am. J. Clin. Path. 21:999 ( (Nov.) ) 1951. 25. Wilson, J. W.; Cawley, E. P.; Weidman, F. D., and Gilmer, W. S.: Prmiary Cutaneous North American Blastomycosis , A. M. A. Arch. Dermat. 71:39 ( (Jan.) ) 1955.Crossref

Journal

A.M.A. Archives of DermatologyAmerican Medical Association

Published: Nov 1, 1957

References