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The Treatment of Dermatomycoses with Orally Administered Griseofulvin

The Treatment of Dermatomycoses with Orally Administered Griseofulvin Abstract The systemic treatment of superficial fungus infections in man at last seems a near reality. Although the polyene antibiotics derived from streptomyces were a significant advance in antifungal chemotherapy against the yeast-like fungi, they failed to influence the common dermatomycoses.1 Recent studies demonstrating the influence of serum factors in superficial fungous infections illustrated the importance of blood-borne substances in confining cutaneous invasion by dermatophytes.2,15 Gentles' recent report of the successful oral treatment of Trichophyton and Microsporum infections in guinea pigs with griseofulvin, a product of several penicillia, was a great step forward.7 Subsequently, Lauder and O'Sullivan found it effective by mouth in calves with Trichophyton verrucosum infections.11 Our paper is a preliminary report of observations on the effectiveness of oral griseofulvin therapy in man. Griseofulvin is a colorless, neutral, thermostable antibiotic isolated from Penicillium griseofulvin by Oxford, Raistrick, and Simonet, References 1. Supplied by Drs. H. M. Walker and A. F. Campbell, of Glaxo Laboratories, England. 2. Blank, H.: Antifungal Antibiotics in Clinical Medicine , A. M. A. Arch Dermat. 75:184, 1957.Crossref 3. Blank, H.; Sagami, S.; Boyd, C. C., and Roth, F. R., Jr.: The Pathogenesis of Superficial Fungous Infections in Cultured Human Skin , A. M. A. Arch. Dermat. to be published. 4. Brian, P. W.: Antibiotics Produced by Fungi , Bot. Rev. 17:357, 1951.Crossref 5. Brian, P. W.; Curtis, P. J., and Hemming, H. J.: Biological Assay, Production and Isolation of "Curling Factor," Tr. Brit. Mycol. Soc. 29:173, 1946.Crossref 6. Brian, P. W.; Hemming, H. G., and McGowan, J. C.: Origin of a Toxicity to Mycorrhiza in Wareham Heath Soil , Nature, London 155:637, 1945.Crossref 7. Brian, P. W.: Antibiotics as Systemic Fungicides and Bactericides , Ann. Applied Biol. 39:434, 1952.Crossref 8. Gentles, J. C.: Experimental Ringworm in Guinea Pigs: Oral Treatment with Griseofulvin , Nature, London 182:476 ( (Aug. 16) ) 1958.Crossref 9. Grove, J. F., and McGowan, J. C.: Identity of Griseofulvin and "Curling Factor," Nature, London 160:574, 1947.Crossref 10. Grove, J. F.; Ismay, D.; MacMillan, J.; Mulholland, T. P. C., and Rogers, M. A. T.: The Structure of Griseofulvin , Chem. & Ind. 11:219, 1951. 11. Grove, J. F.; MacMillan, J.; Mulholland, T. P. C., and Rogers, M. A. T.: Griseofulvin: IV. Structure , J. Chem. Soc. 3977, 1952. 12. Lauder, I. M., and O'Sullivan, J. G.: Vet. Rec. 70:949, 1958. 13. Paget, G. E., and Walpole, A. L.: Some Cytological Effects of Griseofulvin , Nature, London 182:1320 ( (Nov. 8) ) 1958. 14. Oxford, A. E.; Raistrick, H., and Simonet, P.: Studies in the Biochemistry of Micro-Organisms: LX. Griseofulvin, C17H17O6Cl, a Metabolic Product of Penicillium Griseo-Fulvum Dierckx , Biochem. J. 33:240, 1939. 15. Roth, F. J., Jr., and Blank, H.: In Vitro Studies of the Antifungal Antibiotic Griseofulvin, to be published. 16. Roth, F. J., Jr.; Boyd, C. C.; Sagami, S., and Blank, H.: An Evaluation of the Fungistatic Activity of Serum , J. Invest. Dermat. to be published. 17. Work, T. S.: The Biochemistry of Antibiotics , Ann. Rev. Biochem. 21:431, 1952. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Dermatology American Medical Association

The Treatment of Dermatomycoses with Orally Administered Griseofulvin

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Publisher
American Medical Association
Copyright
Copyright © 1959 American Medical Association. All Rights Reserved.
ISSN
0096-5359
DOI
10.1001/archderm.1959.01560150001001
Publisher site
See Article on Publisher Site

Abstract

Abstract The systemic treatment of superficial fungus infections in man at last seems a near reality. Although the polyene antibiotics derived from streptomyces were a significant advance in antifungal chemotherapy against the yeast-like fungi, they failed to influence the common dermatomycoses.1 Recent studies demonstrating the influence of serum factors in superficial fungous infections illustrated the importance of blood-borne substances in confining cutaneous invasion by dermatophytes.2,15 Gentles' recent report of the successful oral treatment of Trichophyton and Microsporum infections in guinea pigs with griseofulvin, a product of several penicillia, was a great step forward.7 Subsequently, Lauder and O'Sullivan found it effective by mouth in calves with Trichophyton verrucosum infections.11 Our paper is a preliminary report of observations on the effectiveness of oral griseofulvin therapy in man. Griseofulvin is a colorless, neutral, thermostable antibiotic isolated from Penicillium griseofulvin by Oxford, Raistrick, and Simonet, References 1. Supplied by Drs. H. M. Walker and A. F. Campbell, of Glaxo Laboratories, England. 2. Blank, H.: Antifungal Antibiotics in Clinical Medicine , A. M. A. Arch Dermat. 75:184, 1957.Crossref 3. Blank, H.; Sagami, S.; Boyd, C. C., and Roth, F. R., Jr.: The Pathogenesis of Superficial Fungous Infections in Cultured Human Skin , A. M. A. Arch. Dermat. to be published. 4. Brian, P. W.: Antibiotics Produced by Fungi , Bot. Rev. 17:357, 1951.Crossref 5. Brian, P. W.; Curtis, P. J., and Hemming, H. J.: Biological Assay, Production and Isolation of "Curling Factor," Tr. Brit. Mycol. Soc. 29:173, 1946.Crossref 6. Brian, P. W.; Hemming, H. G., and McGowan, J. C.: Origin of a Toxicity to Mycorrhiza in Wareham Heath Soil , Nature, London 155:637, 1945.Crossref 7. Brian, P. W.: Antibiotics as Systemic Fungicides and Bactericides , Ann. Applied Biol. 39:434, 1952.Crossref 8. Gentles, J. C.: Experimental Ringworm in Guinea Pigs: Oral Treatment with Griseofulvin , Nature, London 182:476 ( (Aug. 16) ) 1958.Crossref 9. Grove, J. F., and McGowan, J. C.: Identity of Griseofulvin and "Curling Factor," Nature, London 160:574, 1947.Crossref 10. Grove, J. F.; Ismay, D.; MacMillan, J.; Mulholland, T. P. C., and Rogers, M. A. T.: The Structure of Griseofulvin , Chem. & Ind. 11:219, 1951. 11. Grove, J. F.; MacMillan, J.; Mulholland, T. P. C., and Rogers, M. A. T.: Griseofulvin: IV. Structure , J. Chem. Soc. 3977, 1952. 12. Lauder, I. M., and O'Sullivan, J. G.: Vet. Rec. 70:949, 1958. 13. Paget, G. E., and Walpole, A. L.: Some Cytological Effects of Griseofulvin , Nature, London 182:1320 ( (Nov. 8) ) 1958. 14. Oxford, A. E.; Raistrick, H., and Simonet, P.: Studies in the Biochemistry of Micro-Organisms: LX. Griseofulvin, C17H17O6Cl, a Metabolic Product of Penicillium Griseo-Fulvum Dierckx , Biochem. J. 33:240, 1939. 15. Roth, F. J., Jr., and Blank, H.: In Vitro Studies of the Antifungal Antibiotic Griseofulvin, to be published. 16. Roth, F. J., Jr.; Boyd, C. C.; Sagami, S., and Blank, H.: An Evaluation of the Fungistatic Activity of Serum , J. Invest. Dermat. to be published. 17. Work, T. S.: The Biochemistry of Antibiotics , Ann. Rev. Biochem. 21:431, 1952.

Journal

A.M.A. Archives of DermatologyAmerican Medical Association

Published: Mar 1, 1959

References