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The Treatment of Acute Friedlaender's Bacillus Pneumonia: A Continuing Problem

The Treatment of Acute Friedlaender's Bacillus Pneumonia: A Continuing Problem Abstract The monumental advances in the therapy of pneumococcal pneumonia over the past 15 years have given the physician a justified confidence that with modern antibiotics the outcome of a case of pneumonia will usually be favorable. Caution is needed lest we apply this confidence uncritically to every case and thereby relax in our efforts to discover uncommon but stubborn bacterial species which may infect the lung. Acute Friedländer's bacillus* pneumonia, though accounting for only a small percentage of such infections, still carries a sufficiently high mortality to make imperative its early recognition and the early institution of appropriate therapy. The ocurrence of a number of fatal cases of acute Friedlander's bacillus pneumonia at the Cincinnati General Hospital during recent years, despite seemingly adequate antibiotic treatment, has prompted us to analyze our experience with this disease. Material and Methods Hospital records of all cases of pulmonary infection due to Klebsiella pneumoniae References 1. The terms Friedländer's bacillus and Klebsiella pneumoniae will be used interchangeably in this article. From the Infectious Disease Laboratory, Department of Medicine, University of Cincinnati College of Medicine and the Cincinnati General Hospital. 2. The chlortetracycline used in this study was Aureomycin supplied by Dr. Stanton M. Hardy, of the Lederle Laboratories Division, American Cyanamid Company. 3. The polymyxin B was Aerosporin, supplied by Burroughs Wellcome & Company, Inc., through the courtesy of Dr. D. S. Searle. 4. Hamburger, M., and Muething, D.: The in Vitro Sensitivity to 8 Antibiotics of Streptococci and Staphylococci Recovered from Cases of Bacterial Endocarditis , J. Lab. & Clin. Med. 37:60 ( (Jan.) ) 1951. 5. Solomon, S.: Primary Friedländer Pneumonia: Report of 32 Cases , J. A. M. A. 108:937 ( (March 20) ) 1937. 6. Bullowa, J. G. M.; Chess, J., and Friedman, N. B.: Pneumonia Due to Bacillus Friedländeri: A Report on 41 Patients, with Consideration of Specific Serum Therapy , Arch. Int. Med. 60:735 ( (Nov.) ) 1937. 7. Perlman, E., and Bullowa, J. G. M.: Primary Bacillus Friedländer (Klebsiella Pneumoniae) Pneumonia: Therapy of B. Friedländer B Pneumonia , Arch. Int. Med. 67:907 ( (May) ) 1941. 8. Nataro, M.; Shapiro, D., and Gordon, A. T.: Acute Primary Klebsiella Pneumonia , J. A. M. A. 144:12 ( (Sept. 2) ) 1950. 9. Gill, R. J.: Treatment of Friedländer's Pneumonia , Am. J. M. Sc. 221:5 ( (Jan.) ) 1951. 10. Kirby, W. M. M., and Coleman, D. H.: Antibiotic Therapy of Friedländer Pneumonia , Am. J. Med. 11:179 ( (Aug.) ) 1951. 11. Barber, J. M., and Grant, A. P.: Friedländer's Pneumonia: A Report on 6 Cases , Brit. M. J. 2:752 ( (Oct. 4) ) 1952. 12. Solomon, S.: Chronic Friedländer Infections of the Lungs; Report of 17 Cases and Observations on Therapy with Sulfapyridine and Sulfanilamide , J. A. M. A. 115:1527 ( (Nov. 2) ) 1940. 13. Finland, M.; Murray, R.; Harris, H. W.; Kilham, L., and Meads, M.: Development of Streptomycin Resistance During Treatment , J. A. M. A. 132:16 ( (Sept. 7) ) 1946. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Internal Medicine American Medical Association

The Treatment of Acute Friedlaender's Bacillus Pneumonia: A Continuing Problem

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Publisher
American Medical Association
Copyright
Copyright © 1957 American Medical Association. All Rights Reserved.
ISSN
0888-2479
DOI
10.1001/archinte.1957.00260010003001
Publisher site
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Abstract

Abstract The monumental advances in the therapy of pneumococcal pneumonia over the past 15 years have given the physician a justified confidence that with modern antibiotics the outcome of a case of pneumonia will usually be favorable. Caution is needed lest we apply this confidence uncritically to every case and thereby relax in our efforts to discover uncommon but stubborn bacterial species which may infect the lung. Acute Friedländer's bacillus* pneumonia, though accounting for only a small percentage of such infections, still carries a sufficiently high mortality to make imperative its early recognition and the early institution of appropriate therapy. The ocurrence of a number of fatal cases of acute Friedlander's bacillus pneumonia at the Cincinnati General Hospital during recent years, despite seemingly adequate antibiotic treatment, has prompted us to analyze our experience with this disease. Material and Methods Hospital records of all cases of pulmonary infection due to Klebsiella pneumoniae References 1. The terms Friedländer's bacillus and Klebsiella pneumoniae will be used interchangeably in this article. From the Infectious Disease Laboratory, Department of Medicine, University of Cincinnati College of Medicine and the Cincinnati General Hospital. 2. The chlortetracycline used in this study was Aureomycin supplied by Dr. Stanton M. Hardy, of the Lederle Laboratories Division, American Cyanamid Company. 3. The polymyxin B was Aerosporin, supplied by Burroughs Wellcome & Company, Inc., through the courtesy of Dr. D. S. Searle. 4. Hamburger, M., and Muething, D.: The in Vitro Sensitivity to 8 Antibiotics of Streptococci and Staphylococci Recovered from Cases of Bacterial Endocarditis , J. Lab. & Clin. Med. 37:60 ( (Jan.) ) 1951. 5. Solomon, S.: Primary Friedländer Pneumonia: Report of 32 Cases , J. A. M. A. 108:937 ( (March 20) ) 1937. 6. Bullowa, J. G. M.; Chess, J., and Friedman, N. B.: Pneumonia Due to Bacillus Friedländeri: A Report on 41 Patients, with Consideration of Specific Serum Therapy , Arch. Int. Med. 60:735 ( (Nov.) ) 1937. 7. Perlman, E., and Bullowa, J. G. M.: Primary Bacillus Friedländer (Klebsiella Pneumoniae) Pneumonia: Therapy of B. Friedländer B Pneumonia , Arch. Int. Med. 67:907 ( (May) ) 1941. 8. Nataro, M.; Shapiro, D., and Gordon, A. T.: Acute Primary Klebsiella Pneumonia , J. A. M. A. 144:12 ( (Sept. 2) ) 1950. 9. Gill, R. J.: Treatment of Friedländer's Pneumonia , Am. J. M. Sc. 221:5 ( (Jan.) ) 1951. 10. Kirby, W. M. M., and Coleman, D. H.: Antibiotic Therapy of Friedländer Pneumonia , Am. J. Med. 11:179 ( (Aug.) ) 1951. 11. Barber, J. M., and Grant, A. P.: Friedländer's Pneumonia: A Report on 6 Cases , Brit. M. J. 2:752 ( (Oct. 4) ) 1952. 12. Solomon, S.: Chronic Friedländer Infections of the Lungs; Report of 17 Cases and Observations on Therapy with Sulfapyridine and Sulfanilamide , J. A. M. A. 115:1527 ( (Nov. 2) ) 1940. 13. Finland, M.; Murray, R.; Harris, H. W.; Kilham, L., and Meads, M.: Development of Streptomycin Resistance During Treatment , J. A. M. A. 132:16 ( (Sept. 7) ) 1946.

Journal

A.M.A. Archives of Internal MedicineAmerican Medical Association

Published: Jan 1, 1957

References