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The Toxic Action of Some Compounds on the Inner Ear and Its Central Vestibular Connections: An Experimental Investigation with Reference to Nitrogen Mustards and Sodium Arsanilate (Atoxyl)

The Toxic Action of Some Compounds on the Inner Ear and Its Central Vestibular Connections: An... Abstract Both the peripheral and the central part of the vestibular apparatus can be specifically affected by a number of substances, chief among which are perhaps arsenical compounds, streptomycin, and nitrogen mustards. As early as 1907 Ehrlich, who at the time was investigating the action of various arsenical chemotherapeutic agents upon trypanosomes, observed a peculiar symptom in mice following injection of arsacetin, an arsenic derivative. In his experiments he used 1 cc. of a 1:166 solution of arsacetin, and found incidentally that some of the mice injected in this way developed waltzing symptoms highly reminiscent of Japanese waltzing mice. On elevation of the dose to 1 cc. of a 1:30 solution, the symptoms occurred regularly and could have a duration of eight to nine months. Ehrlich did not study any lesions that arsacetin might have produced. Röthig (1909), on the contrary, made a detailed histologic examination of the central portion of References 1. Berg, K.: The Toxic Effect of Streptomycin on the Vestibular and Cochlear Apparatus , Acta oto-laryng , (Supp. 97) , 1951. 2. Bergström, O., and Koch, Hj.: The Effect of Chlorpromazine on the Vestibular Function , Acta oto-laryng. 46:484, 1956.Crossref 3. Brug, J., and Funcke, A. B. H.: Toxic Reactions on the Labyrinthine Reflexes Caused by Tetra-Ethyl-Thiuramdisulphide , Arch. internat. pharmacodyn. 87:113, 1951. 4. Davini, V.: La lesioni vestibolari centrali nei topi intossicati con acidó diclorofenol-arsinico , Accad. med., Torino 65:107, 1950. 5. Diamant, H.: Vestibulärt syndrom enligt Forssman-Skoog framkallat av anticholinesteraser och cholinestrar , Förh. Svensk Otolaryng. Fören. , Vol. 4, 1952-1953. 6. Cholinesterase Inhibitors and Vestibular Function , Acta oto-laryng , (Supp. 111) , 1954. 7. Ehrlich, P.: Chemotherapeutische trypanosomen Studien , Berl. klin. Wchnschr. 44:280, 1907. 8. Femenić, B., and Salaj, B.: Toxic Effects of Streptomycin on the Stato-Acoustic Apparatus , Rad de l'Acad. Yougoslave 298:189, 1953. 9. Fischl, V., and Schlossberger, H.: Phenylarsinsäuren , in Handbuch der Chemotherapie , Leipzig, Fischers Medizinische Buchhandlung, 1934. 10. Floberg, L.-E.: Vestibular Symptoms in Carbon Monoxide Poisoning after Unilateral Ligation of the Common Carotid Artery , Acta otolaryng. , (Supp. 106) , 1953. 11. Floberg Hamberger, C.-A., and Hydén, H.: Inhibition of Nucleic Acid Production in Vestibular Nerve Cells by Streptomycin . Acta oto-laryng. , (Suppl. 75) , 1949. 12. Floberg and Koch, H.: Vestibular Symptoms Elicited Through Allergy , Acta oto-laryng. , (Supp. 116) , p. 94, 1954. 13. Goldin, A.; Noe, H. A.; Landing, B. H.; Shapiro, D. M., and Goldberg, B.: A Neurological Syndrome Induced by Administration of Some Chlorinated Tertiary Amines , J. Pharmacol. & Exper. Therap. 94:249, 1948. 14. Hanzlik, P. J., and Irvine, A.: The Toxicity of Some Thioureas and Thiuram-disulphides , J. Pharmacol. & Exper. Therap. 17:349, 1921. 15. Jongkees, L. B. W., and Hulk, J.: The Action of Streptomycin on Vestibular Function , Acta oto-laryng. 38:225, 1950. 16. Krop, S.; Wescoe, W. C.; Goldin, A., and Landing, B.: Central Nervous System Injury in Experimental Animals by Betachloroethyl Morpholine , Fed. Proc. 6:347, 1947. 17. E. Merck's Jahresbericht, 1911. 18. Miehlke, A.: Über die schädigende Wirkung des Ammoniaks auf die Vestibularfunktionen bei Mensch und Tier , Ztschr. Laryng. Rhin. Otol. 31:565, 1952. 19. Napolitano, L., and Longo, V. G.: Azione dell'ortotoluolossipropandiolo (Mephenesin, Myanesin) sul nistagmo vestibolare, confronto con il benzimidazolo il glyketal e la diidrobenzo 1-4 tiazina , Arch. internat. pharmacodyn. 90:343, 1952. 20. Nassuphis, P.: Die Wirkung des Atoxyls auf das Innenohr , Arch. Ohren- Nasen-u. Kehlkopfh. 157:594, 1951. 21. Peters, R. A.: Present State of Knowledge of Biochemical Lesions Induced by Trivalent Arsenical Poisoning , Bull. Johns Hopkins Hosp. 97:1, 1955. 22. Röthig, P.: Weitere Untersuchungen am Zentralnervensystem von mit Arsacetin behandelten Mäusen (sogenannten künstlichen Tanzmäusen) , Deutsche med. Wchnschr. 35:2213, 1909. 23. Scheinker, M.: Genesis of Encephalopathy Due to Arsphenamine , Arch. Path. 37:91, 1944. 24. Skoog, T., in discussion on Christensen, E.; Hertz, H.; Riskaer, N., and Vraa-Jensen, G.: Experiments on the Neurotoxic Effect of Streptomycin, Transactions of the XI Northern Oto-Laryngological Congress (1950) , Acta oto-laryng. (Supp. 95) , p. 181, 1951. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Otolaryngology American Medical Association

The Toxic Action of Some Compounds on the Inner Ear and Its Central Vestibular Connections: An Experimental Investigation with Reference to Nitrogen Mustards and Sodium Arsanilate (Atoxyl)

DIAMANT, HERMAN
A.M.A. Archives of Otolaryngology , Volume 67 (5) – May 1, 1958
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References (24)

Publisher
American Medical Association
Copyright
Copyright © 1958 American Medical Association. All Rights Reserved.
ISSN
0096-6894
DOI
10.1001/archotol.1958.00730010560008
Publisher site
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Abstract

Abstract Both the peripheral and the central part of the vestibular apparatus can be specifically affected by a number of substances, chief among which are perhaps arsenical compounds, streptomycin, and nitrogen mustards. As early as 1907 Ehrlich, who at the time was investigating the action of various arsenical chemotherapeutic agents upon trypanosomes, observed a peculiar symptom in mice following injection of arsacetin, an arsenic derivative. In his experiments he used 1 cc. of a 1:166 solution of arsacetin, and found incidentally that some of the mice injected in this way developed waltzing symptoms highly reminiscent of Japanese waltzing mice. On elevation of the dose to 1 cc. of a 1:30 solution, the symptoms occurred regularly and could have a duration of eight to nine months. Ehrlich did not study any lesions that arsacetin might have produced. Röthig (1909), on the contrary, made a detailed histologic examination of the central portion of References 1. Berg, K.: The Toxic Effect of Streptomycin on the Vestibular and Cochlear Apparatus , Acta oto-laryng , (Supp. 97) , 1951. 2. Bergström, O., and Koch, Hj.: The Effect of Chlorpromazine on the Vestibular Function , Acta oto-laryng. 46:484, 1956.Crossref 3. Brug, J., and Funcke, A. B. H.: Toxic Reactions on the Labyrinthine Reflexes Caused by Tetra-Ethyl-Thiuramdisulphide , Arch. internat. pharmacodyn. 87:113, 1951. 4. Davini, V.: La lesioni vestibolari centrali nei topi intossicati con acidó diclorofenol-arsinico , Accad. med., Torino 65:107, 1950. 5. Diamant, H.: Vestibulärt syndrom enligt Forssman-Skoog framkallat av anticholinesteraser och cholinestrar , Förh. Svensk Otolaryng. Fören. , Vol. 4, 1952-1953. 6. Cholinesterase Inhibitors and Vestibular Function , Acta oto-laryng , (Supp. 111) , 1954. 7. Ehrlich, P.: Chemotherapeutische trypanosomen Studien , Berl. klin. Wchnschr. 44:280, 1907. 8. Femenić, B., and Salaj, B.: Toxic Effects of Streptomycin on the Stato-Acoustic Apparatus , Rad de l'Acad. Yougoslave 298:189, 1953. 9. Fischl, V., and Schlossberger, H.: Phenylarsinsäuren , in Handbuch der Chemotherapie , Leipzig, Fischers Medizinische Buchhandlung, 1934. 10. Floberg, L.-E.: Vestibular Symptoms in Carbon Monoxide Poisoning after Unilateral Ligation of the Common Carotid Artery , Acta otolaryng. , (Supp. 106) , 1953. 11. Floberg Hamberger, C.-A., and Hydén, H.: Inhibition of Nucleic Acid Production in Vestibular Nerve Cells by Streptomycin . Acta oto-laryng. , (Suppl. 75) , 1949. 12. Floberg and Koch, H.: Vestibular Symptoms Elicited Through Allergy , Acta oto-laryng. , (Supp. 116) , p. 94, 1954. 13. Goldin, A.; Noe, H. A.; Landing, B. H.; Shapiro, D. M., and Goldberg, B.: A Neurological Syndrome Induced by Administration of Some Chlorinated Tertiary Amines , J. Pharmacol. & Exper. Therap. 94:249, 1948. 14. Hanzlik, P. J., and Irvine, A.: The Toxicity of Some Thioureas and Thiuram-disulphides , J. Pharmacol. & Exper. Therap. 17:349, 1921. 15. Jongkees, L. B. W., and Hulk, J.: The Action of Streptomycin on Vestibular Function , Acta oto-laryng. 38:225, 1950. 16. Krop, S.; Wescoe, W. C.; Goldin, A., and Landing, B.: Central Nervous System Injury in Experimental Animals by Betachloroethyl Morpholine , Fed. Proc. 6:347, 1947. 17. E. Merck's Jahresbericht, 1911. 18. Miehlke, A.: Über die schädigende Wirkung des Ammoniaks auf die Vestibularfunktionen bei Mensch und Tier , Ztschr. Laryng. Rhin. Otol. 31:565, 1952. 19. Napolitano, L., and Longo, V. G.: Azione dell'ortotoluolossipropandiolo (Mephenesin, Myanesin) sul nistagmo vestibolare, confronto con il benzimidazolo il glyketal e la diidrobenzo 1-4 tiazina , Arch. internat. pharmacodyn. 90:343, 1952. 20. Nassuphis, P.: Die Wirkung des Atoxyls auf das Innenohr , Arch. Ohren- Nasen-u. Kehlkopfh. 157:594, 1951. 21. Peters, R. A.: Present State of Knowledge of Biochemical Lesions Induced by Trivalent Arsenical Poisoning , Bull. Johns Hopkins Hosp. 97:1, 1955. 22. Röthig, P.: Weitere Untersuchungen am Zentralnervensystem von mit Arsacetin behandelten Mäusen (sogenannten künstlichen Tanzmäusen) , Deutsche med. Wchnschr. 35:2213, 1909. 23. Scheinker, M.: Genesis of Encephalopathy Due to Arsphenamine , Arch. Path. 37:91, 1944. 24. Skoog, T., in discussion on Christensen, E.; Hertz, H.; Riskaer, N., and Vraa-Jensen, G.: Experiments on the Neurotoxic Effect of Streptomycin, Transactions of the XI Northern Oto-Laryngological Congress (1950) , Acta oto-laryng. (Supp. 95) , p. 181, 1951.

Journal

A.M.A. Archives of Otolaryngology – American Medical Association

Published: May 1, 1958

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