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The Time Is Now for Gene- and Genome-Based Bacterial Diagnostics

The Time Is Now for Gene- and Genome-Based Bacterial Diagnostics Gene- and Genome-Based Bacterial Diagnostics Invited Commentary Research Invited Commentary The Time Is Now for Gene- and Genome-Based Bacterial Diagnostics “You Say You Want a Revolution” Garth D. Ehrlich, PhD; J. Christopher Post, MD, PhD Clinical microbiology is poised to move into a dynamic age by Whole-genome sequencing is critical as a diagnostic tool be- embracing molecular diagnostic techniques, such as poly- cause the vast majority of bacterial pathogens possess a su- merase chain reaction–based amplification techniques and pragenome that is much larger than the genome of any indi- whole-genome sequencing (WGS). These technologies will vidual strain. A species supragenome contains 3 different sets revolutionize data acquisition for theranostics and the track- of genes: (1) the core genes, which are found in every strain of ing of outbreaks. the species; (2) the distributed genes, which are found in a sub- Whole-genome sequencing originally proved its worth set of strains of the species; and (3) the unique genes, which through investigations of infectious agents. In this issue of are found in only a single strain of that species. Thus, each JAMA Internal Medicine, Reuter et al now advocate WGS for strain has a unique distribution of noncore genes from the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Internal Medicine American Medical Association

The Time Is Now for Gene- and Genome-Based Bacterial Diagnostics

JAMA Internal Medicine , Volume 173 (15) – Aug 12, 2013

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Publisher
American Medical Association
Copyright
Copyright 2013 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6106
eISSN
2168-6114
DOI
10.1001/jamainternmed.2013.7042
pmid
23857368
Publisher site
See Article on Publisher Site

Abstract

Gene- and Genome-Based Bacterial Diagnostics Invited Commentary Research Invited Commentary The Time Is Now for Gene- and Genome-Based Bacterial Diagnostics “You Say You Want a Revolution” Garth D. Ehrlich, PhD; J. Christopher Post, MD, PhD Clinical microbiology is poised to move into a dynamic age by Whole-genome sequencing is critical as a diagnostic tool be- embracing molecular diagnostic techniques, such as poly- cause the vast majority of bacterial pathogens possess a su- merase chain reaction–based amplification techniques and pragenome that is much larger than the genome of any indi- whole-genome sequencing (WGS). These technologies will vidual strain. A species supragenome contains 3 different sets revolutionize data acquisition for theranostics and the track- of genes: (1) the core genes, which are found in every strain of ing of outbreaks. the species; (2) the distributed genes, which are found in a sub- Whole-genome sequencing originally proved its worth set of strains of the species; and (3) the unique genes, which through investigations of infectious agents. In this issue of are found in only a single strain of that species. Thus, each JAMA Internal Medicine, Reuter et al now advocate WGS for strain has a unique distribution of noncore genes from the

Journal

JAMA Internal MedicineAmerican Medical Association

Published: Aug 12, 2013

References