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THE THERAPEUTIC USE OF TRYPARSAMID IN NEUROSYPHILIS

THE THERAPEUTIC USE OF TRYPARSAMID IN NEUROSYPHILIS In the latter part of 1919, we entered on a study of the treatment of syphilis of the central nervous system with a view to the development and use of new drugs. At the suggestion of Dr. Wade H. Brown, we began our study with tryparsamid, the sodium salt of N-Phenyl-glycineamid-p-arsonic acid, C6H4(NHCH2CONH2) · (AsO · OH·ONa), which was first made by Jacobs and Heidelberger1 in 1915. The biologic action of this substance has been studied experimentally by Brown and Pearce2 in normal animals and in animals infected with trypanosomes and with the spirochetes of relapsing fever and of syphilis. Tryparsamid had also been used in a comparatively small group of patients for the treatment of syphilis other than that of the central nervous system, first by Louise Pearce and later by Keidel and Moore; and at the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

THE THERAPEUTIC USE OF TRYPARSAMID IN NEUROSYPHILIS

LORENZ, W. F.; LOEVENHART, A. S.; BLECKWENN, W. J.; HODGES, F. J.
JAMA , Volume 80 (21) – May 26, 1923
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References (3)

Publisher
American Medical Association
Copyright
Copyright © 1923 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1923.02640480001001
Publisher site
See Article on Publisher Site

Abstract

In the latter part of 1919, we entered on a study of the treatment of syphilis of the central nervous system with a view to the development and use of new drugs. At the suggestion of Dr. Wade H. Brown, we began our study with tryparsamid, the sodium salt of N-Phenyl-glycineamid-p-arsonic acid, C6H4(NHCH2CONH2) · (AsO · OH·ONa), which was first made by Jacobs and Heidelberger1 in 1915. The biologic action of this substance has been studied experimentally by Brown and Pearce2 in normal animals and in animals infected with trypanosomes and with the spirochetes of relapsing fever and of syphilis. Tryparsamid had also been used in a comparatively small group of patients for the treatment of syphilis other than that of the central nervous system, first by Louise Pearce and later by Keidel and Moore; and at the

Journal

JAMA – American Medical Association

Published: May 26, 1923

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