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The Superiority of Combined Therapy (Surgery and Postoperative Irradiation) in Parotid Cancer

The Superiority of Combined Therapy (Surgery and Postoperative Irradiation) in Parotid Cancer Abstract • A retrospective evaluation was done on 120 patients treated for parotid cancer. The aim of the study was to establish the role of postoperative radiation therapy. Fifty-nine patients were treated by surgery alone and an equal number of patients received surgery plus postoperative radiation therapy. Two patients were treated by preoperative irrradiation. The overall 5-, 10-, and 15-year survival rates were 81%, 62%, and 65%, respectively. Postoperative radiation therapy proved to increase local control over surgery alone whenever (1) there was locally advanced disease, (2) the tumor belonged to a so-called poorly differentiated variety, (3) the treatment was given for a recurrent lesion, and/or (4) there was tumor involvement of the facial nerve. It did not appear that postoperative radiation therapy increased the survival for patients with low-grade malignant tumors. Radiation therapy should be given as early as possible after surgery and the optimum dose ranges from 3,000 to 5,000 rad given in three to five weeks, respectively. (Arch Otolaryngol 1982;108:710-713) References 1. Taylor BG, Cohr I Jr: Tumors of the salivary glands . Curr Probl Cancer 1978;3( (4) ):7-30.Crossref 2. King JJ, Fletcher GH: Malignant tumors of the major salivary glands . Radiology 1971;100:382-384. 3. Guillamondegui OM, Byers RM, Luna MA, et al: Aggressive surgery in treatment for parotid cancer: The role of adjunctive postoperative radiotherapy . AJR 1975;123:49-54.Crossref 4. Shidnia H, Hornback NB, Hamaker R, et al: Carcinoma of major salivary glands . Cancer 1980;45:693-697.Crossref 5. Fletcher GH: Combination of irradiation and surgery , in International Advances in Surgical Oncology . New York, Alan R Liss Inc, 1979, vol 2, pp 55-98. 6. Spiro RH, Huvos AG, Strong EW: Cancer of the parotid gland: A clinicopathologic study of 288 primary cases . Am J Surg 1975;130:452-459.Crossref 7. The Classification of Malignant Tumors: The Principles of the TNM System , ed 3. Geneva, International Union Against Cancer (UICC), 1978. 8. Boles R, Raines J, Lebovits M, et al: Malignant tumors of salivary glands: A university experience . Laryngoscope 1980;90:729-736.Crossref 9. Kagan AR, Nussbaum H, Handler S, et al: Recurrences from malignant parotid salivary gland tumors . Cancer 1976;37:2600-2604.Crossref 10. Conley J, Hamaker RC: Prognosis of malignant tumors of the parotid gland with facial paralysis . Arch Otolaryngol 1975;101:39-41.Crossref 11. Fu KK, Leibel SA, Levine ML, et al: Carcinoma of the major and minor salivary glands . Cancer 1977;40:2882-2890.Crossref 12. Rossman KJ: The role of radiation therapy in the treatment of parotid carcinoma . AJR 1975;123:492-499.Crossref 13. Spiro RH, Huvos AG, Berk R, et al: Mucoepidermoid carcinoma of salivary gland origin: A clinicopathologic study of 367 cases . Am J Surg 1978;136:461-468.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Otolaryngology American Medical Association

The Superiority of Combined Therapy (Surgery and Postoperative Irradiation) in Parotid Cancer

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Publisher
American Medical Association
Copyright
Copyright © 1982 American Medical Association. All Rights Reserved.
ISSN
0003-9977
DOI
10.1001/archotol.1982.00790590032010
Publisher site
See Article on Publisher Site

Abstract

Abstract • A retrospective evaluation was done on 120 patients treated for parotid cancer. The aim of the study was to establish the role of postoperative radiation therapy. Fifty-nine patients were treated by surgery alone and an equal number of patients received surgery plus postoperative radiation therapy. Two patients were treated by preoperative irrradiation. The overall 5-, 10-, and 15-year survival rates were 81%, 62%, and 65%, respectively. Postoperative radiation therapy proved to increase local control over surgery alone whenever (1) there was locally advanced disease, (2) the tumor belonged to a so-called poorly differentiated variety, (3) the treatment was given for a recurrent lesion, and/or (4) there was tumor involvement of the facial nerve. It did not appear that postoperative radiation therapy increased the survival for patients with low-grade malignant tumors. Radiation therapy should be given as early as possible after surgery and the optimum dose ranges from 3,000 to 5,000 rad given in three to five weeks, respectively. (Arch Otolaryngol 1982;108:710-713) References 1. Taylor BG, Cohr I Jr: Tumors of the salivary glands . Curr Probl Cancer 1978;3( (4) ):7-30.Crossref 2. King JJ, Fletcher GH: Malignant tumors of the major salivary glands . Radiology 1971;100:382-384. 3. Guillamondegui OM, Byers RM, Luna MA, et al: Aggressive surgery in treatment for parotid cancer: The role of adjunctive postoperative radiotherapy . AJR 1975;123:49-54.Crossref 4. Shidnia H, Hornback NB, Hamaker R, et al: Carcinoma of major salivary glands . Cancer 1980;45:693-697.Crossref 5. Fletcher GH: Combination of irradiation and surgery , in International Advances in Surgical Oncology . New York, Alan R Liss Inc, 1979, vol 2, pp 55-98. 6. Spiro RH, Huvos AG, Strong EW: Cancer of the parotid gland: A clinicopathologic study of 288 primary cases . Am J Surg 1975;130:452-459.Crossref 7. The Classification of Malignant Tumors: The Principles of the TNM System , ed 3. Geneva, International Union Against Cancer (UICC), 1978. 8. Boles R, Raines J, Lebovits M, et al: Malignant tumors of salivary glands: A university experience . Laryngoscope 1980;90:729-736.Crossref 9. Kagan AR, Nussbaum H, Handler S, et al: Recurrences from malignant parotid salivary gland tumors . Cancer 1976;37:2600-2604.Crossref 10. Conley J, Hamaker RC: Prognosis of malignant tumors of the parotid gland with facial paralysis . Arch Otolaryngol 1975;101:39-41.Crossref 11. Fu KK, Leibel SA, Levine ML, et al: Carcinoma of the major and minor salivary glands . Cancer 1977;40:2882-2890.Crossref 12. Rossman KJ: The role of radiation therapy in the treatment of parotid carcinoma . AJR 1975;123:492-499.Crossref 13. Spiro RH, Huvos AG, Berk R, et al: Mucoepidermoid carcinoma of salivary gland origin: A clinicopathologic study of 367 cases . Am J Surg 1978;136:461-468.Crossref

Journal

Archives of OtolaryngologyAmerican Medical Association

Published: Nov 1, 1982

References