Abstract Over a five-year span 1,134 patients with asymptomatic solitary pulmonary nodules were entered into a cooperative study. Of the 392 lesions found to be primary bronchogenic carcinoma, 67 patients were living and under observation ten years following operation. In the study, 32% of lesions were primary bronchogenic carcinoma, the incidence being 51% in patients above the age of 50 years. "Curative" resection was possible in 309 patients (78.9%) with a five-year observed survival of 38.5% and a ten-year observed survival of 20.1%. Factors that influenced long-term survival were size of lesion, age at operation, and interval between the last normal and the first abnormal x-ray film. Histologic cell type and extent of resection were not found to influence long-term survival. References 1. Steele JD: The Solitary Pulmonary Nodule . Springfield, Ill, Charles C Thomas Publisher, 1964. 2. Steele JD, Kleitsch WP, Dunn JE Jr, et al: Survival in males with bronchogenic carcinomas resected as solitary pulmonary nodules . Ann Thorac Surg 2:368-376, 1966.Crossref 3. Steele JD, Buell P: Survival in bronchogenic carcinomas resected as solitary pulmonary nodules. Read before the sixth National Cancer Conference, Denver, 1969. 4. Steele JD, Buell P: Asymptomatic solitary pulmonary nodules . J Thorac Cardiovasc Surg 65:140-151, 1973. 5. Shields TW: The fate of patients after incomplete resection of bronchial carcinoma . Surg Gynecol Obstet 139:569-572, 1974. 6. Feinstein AR, Gelfman NA, Yesner R: Observer variability in the histopathologic diagnosis of lung cancer . Am Rev Resp Dis 101:671-684, 1970. 7. Yesner R: Observer variability and reliability in lung cancer diagnosis . Cancer Chemother Rep 4:55-57, 1973. 8. Kreyberg L: Histological Typing of Lung Tumours . Geneva, World Health Organization, 1967. 9. Woolner LB: Atlas of Peripheral Lung Tumors . Chicago, American Society of Clinical Pathologists, 1969. 10. Kuang DT, Wolf J, Hyde L, et al: Preliminary report on the treatment of nonresectable cancer of the lung . Cancer Chemother Rep 58:359-364, 1974. 11. Garland LH: Growth and duration of primary bronchogenic carcinoma . Am J Roentgenol Radium Ther Nucl Med 96:604-611, 1966.Crossref 12. Weiss W: Tumor doubling time and survival of men with bronchogenic carcinoma . Chest 65:3-8, 1974.Crossref 13. Higgins GA, Lawton R, Heilbrunn A, et al: Prognostic factors in lung cancer . Ann Thorac Surg 7:472-480, 1969.Crossref 14. Meyer JA: Growth rate versus prognosis in resected primary bronchogenic carcinoma . Cancer 31:1468-1472, 1973.Crossref 15. Shields TW, Robinette CD: Long-term survival after resection of bronchial carcinoma . Surg Gynecol Obstet 136:759-762, 1973.
Archives of Surgery – American Medical Association
Published: May 1, 1975