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The Skin Is Not the Predominant Problem in Incontinentia Pigmenti

The Skin Is Not the Predominant Problem in Incontinentia Pigmenti COMMENTARY The Skin Is Not the Predominant Problem in Incontinentia Pigmenti LINICAL CONSTER- mic infarctions (and loss of func- factor–kappa B essential modula- nation occurs when tion) ensue, often eventuating in tor) leads to activation of eotaxin, characteristic ve- preretinal neovascularization, hem- a potent eosinophil-selective che- siculobullous erup- orrhages, and retinal detach- mokine, which is directly and spe- 25,26 C tions of incontinen- ment. The retina shares a com- cifically chemotactic for eosino- tia pigmenti (IP) appear neonatally. mon embryologic origin with the phils. Eotaxin is abnormally These distressing lesions almost brain and, like it, does not regener- present in the skin of patients with never lead to serious long-term mor- ate following such ischemic in- IP during the vesiculobullous stage bidity, although they often result in sults. and in vascular endothelial cells as time-consuming, expensive, and Unlike the retina, the brain and well, findings which correlate with typically fruitless diagnostic evalu- its blood vessels cannot be directly perivascular and intravascular eo- ations in an attempt to diagnose visualized during a physical exami- sinophil infiltration in the skin. other diseases. nation. Nonetheless, standard diag- These cellular changes appear to be Blindness and psychomotor re- nostic tests, such as arteriography, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Dermatology American Medical Association

The Skin Is Not the Predominant Problem in Incontinentia Pigmenti

JAMA Dermatology , Volume 140 (6) – Jun 1, 2004

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Publisher
American Medical Association
Copyright
Copyright 2004 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6068
eISSN
2168-6084
DOI
10.1001/archderm.140.6.748
pmid
15210470
Publisher site
See Article on Publisher Site

Abstract

COMMENTARY The Skin Is Not the Predominant Problem in Incontinentia Pigmenti LINICAL CONSTER- mic infarctions (and loss of func- factor–kappa B essential modula- nation occurs when tion) ensue, often eventuating in tor) leads to activation of eotaxin, characteristic ve- preretinal neovascularization, hem- a potent eosinophil-selective che- siculobullous erup- orrhages, and retinal detach- mokine, which is directly and spe- 25,26 C tions of incontinen- ment. The retina shares a com- cifically chemotactic for eosino- tia pigmenti (IP) appear neonatally. mon embryologic origin with the phils. Eotaxin is abnormally These distressing lesions almost brain and, like it, does not regener- present in the skin of patients with never lead to serious long-term mor- ate following such ischemic in- IP during the vesiculobullous stage bidity, although they often result in sults. and in vascular endothelial cells as time-consuming, expensive, and Unlike the retina, the brain and well, findings which correlate with typically fruitless diagnostic evalu- its blood vessels cannot be directly perivascular and intravascular eo- ations in an attempt to diagnose visualized during a physical exami- sinophil infiltration in the skin. other diseases. nation. Nonetheless, standard diag- These cellular changes appear to be Blindness and psychomotor re- nostic tests, such as arteriography,

Journal

JAMA DermatologyAmerican Medical Association

Published: Jun 1, 2004

References